Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation

The nucleolus is a membrane-less organelle formed through liquid–liquid phase separation (LLPS). Here the authors use biophysical methods and show that the nucleolar protein nucleophosmin (NPM1) also undergoes LLPS through homotypic, inter-NPM1 interactions and discuss implications for the ribosome...

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Autores principales:	Diana M. Mitrea, Jaclyn A. Cika, Christopher B. Stanley, Amanda Nourse, Paulo L. Onuchic, Priya R. Banerjee, Aaron H. Phillips, Cheon-Gil Park, Ashok A. Deniz, Richard W. Kriwacki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b0e551cefaf8425ca521312004e29d42
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id	oai:doaj.org-article:b0e551cefaf8425ca521312004e29d42
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spelling	oai:doaj.org-article:b0e551cefaf8425ca521312004e29d422021-12-02T15:34:38ZSelf-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation10.1038/s41467-018-03255-32041-1723https://doaj.org/article/b0e551cefaf8425ca521312004e29d422018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03255-3https://doaj.org/toc/2041-1723The nucleolus is a membrane-less organelle formed through liquid–liquid phase separation (LLPS). Here the authors use biophysical methods and show that the nucleolar protein nucleophosmin (NPM1) also undergoes LLPS through homotypic, inter-NPM1 interactions and discuss implications for the ribosome biogenesis process.Diana M. MitreaJaclyn A. CikaChristopher B. StanleyAmanda NoursePaulo L. OnuchicPriya R. BanerjeeAaron H. PhillipsCheon-Gil ParkAshok A. DenizRichard W. KriwackiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Diana M. Mitrea Jaclyn A. Cika Christopher B. Stanley Amanda Nourse Paulo L. Onuchic Priya R. Banerjee Aaron H. Phillips Cheon-Gil Park Ashok A. Deniz Richard W. Kriwacki Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation
description	The nucleolus is a membrane-less organelle formed through liquid–liquid phase separation (LLPS). Here the authors use biophysical methods and show that the nucleolar protein nucleophosmin (NPM1) also undergoes LLPS through homotypic, inter-NPM1 interactions and discuss implications for the ribosome biogenesis process.
format	article
author	Diana M. Mitrea Jaclyn A. Cika Christopher B. Stanley Amanda Nourse Paulo L. Onuchic Priya R. Banerjee Aaron H. Phillips Cheon-Gil Park Ashok A. Deniz Richard W. Kriwacki
author_facet	Diana M. Mitrea Jaclyn A. Cika Christopher B. Stanley Amanda Nourse Paulo L. Onuchic Priya R. Banerjee Aaron H. Phillips Cheon-Gil Park Ashok A. Deniz Richard W. Kriwacki
author_sort	Diana M. Mitrea
title	Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation
title_short	Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation
title_full	Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation
title_fullStr	Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation
title_full_unstemmed	Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation
title_sort	self-interaction of npm1 modulates multiple mechanisms of liquid–liquid phase separation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b0e551cefaf8425ca521312004e29d42
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Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation

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