Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation

Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation

The nucleolus is a membrane-less organelle formed through liquid–liquid phase separation (LLPS). Here the authors use biophysical methods and show that the nucleolar protein nucleophosmin (NPM1) also undergoes LLPS through homotypic, inter-NPM1 interactions and discuss implications for the ribosome...

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Autores principales: Diana M. Mitrea, Jaclyn A. Cika, Christopher B. Stanley, Amanda Nourse, Paulo L. Onuchic, Priya R. Banerjee, Aaron H. Phillips, Cheon-Gil Park, Ashok A. Deniz, Richard W. Kriwacki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/b0e551cefaf8425ca521312004e29d42
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