Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis

Chemotaxis during differentiation of Dictyostelium discoideum requires four signalling pathways to maintain directional cell migration, but it is unclear how they are coordinated. Here the authors show that the RNA-binding protein Pumilio localizes mRNAs and proteins of these pathways and actin at t...

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Autores principales:	Manuel Hotz, W. James Nelson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b0e5b5de35ad41e8a7b7195dd7b1414a
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spelling	oai:doaj.org-article:b0e5b5de35ad41e8a7b7195dd7b1414a2021-12-02T14:42:36ZPumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis10.1038/s41467-017-01536-x2041-1723https://doaj.org/article/b0e5b5de35ad41e8a7b7195dd7b1414a2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01536-xhttps://doaj.org/toc/2041-1723Chemotaxis during differentiation of Dictyostelium discoideum requires four signalling pathways to maintain directional cell migration, but it is unclear how they are coordinated. Here the authors show that the RNA-binding protein Pumilio localizes mRNAs and proteins of these pathways and actin at the cell front during dynamic cell migration.Manuel HotzW. James NelsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manuel Hotz W. James Nelson Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis
description	Chemotaxis during differentiation of Dictyostelium discoideum requires four signalling pathways to maintain directional cell migration, but it is unclear how they are coordinated. Here the authors show that the RNA-binding protein Pumilio localizes mRNAs and proteins of these pathways and actin at the cell front during dynamic cell migration.
format	article
author	Manuel Hotz W. James Nelson
author_facet	Manuel Hotz W. James Nelson
author_sort	Manuel Hotz
title	Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis
title_short	Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis
title_full	Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis
title_fullStr	Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis
title_full_unstemmed	Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis
title_sort	pumilio-dependent localization of mrnas at the cell front coordinates multiple pathways required for chemotaxis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b0e5b5de35ad41e8a7b7195dd7b1414a
work_keys_str_mv	AT manuelhotz pumiliodependentlocalizationofmrnasatthecellfrontcoordinatesmultiplepathwaysrequiredforchemotaxis AT wjamesnelson pumiliodependentlocalizationofmrnasatthecellfrontcoordinatesmultiplepathwaysrequiredforchemotaxis
_version_	1718389653670723584

Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis

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