Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis

Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis

Chemotaxis during differentiation of Dictyostelium discoideum requires four signalling pathways to maintain directional cell migration, but it is unclear how they are coordinated. Here the authors show that the RNA-binding protein Pumilio localizes mRNAs and proteins of these pathways and actin at t...

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Auteurs principaux: Manuel Hotz, W. James Nelson
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Science
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Accès en ligne:https://doaj.org/article/b0e5b5de35ad41e8a7b7195dd7b1414a
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spelling oai:doaj.org-article:b0e5b5de35ad41e8a7b7195dd7b1414a2021-12-02T14:42:36ZPumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis10.1038/s41467-017-01536-x2041-1723https://doaj.org/article/b0e5b5de35ad41e8a7b7195dd7b1414a2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01536-xhttps://doaj.org/toc/2041-1723Chemotaxis during differentiation of Dictyostelium discoideum requires four signalling pathways to maintain directional cell migration, but it is unclear how they are coordinated. Here the authors show that the RNA-binding protein Pumilio localizes mRNAs and proteins of these pathways and actin at the cell front during dynamic cell migration.Manuel HotzW. James NelsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Manuel Hotz
W. James Nelson
Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis
description Chemotaxis during differentiation of Dictyostelium discoideum requires four signalling pathways to maintain directional cell migration, but it is unclear how they are coordinated. Here the authors show that the RNA-binding protein Pumilio localizes mRNAs and proteins of these pathways and actin at the cell front during dynamic cell migration.
format article
author Manuel Hotz
W. James Nelson
author_facet Manuel Hotz
W. James Nelson
author_sort Manuel Hotz
title Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis
title_short Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis
title_full Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis
title_fullStr Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis
title_full_unstemmed Pumilio-dependent localization of mRNAs at the cell front coordinates multiple pathways required for chemotaxis
title_sort pumilio-dependent localization of mrnas at the cell front coordinates multiple pathways required for chemotaxis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b0e5b5de35ad41e8a7b7195dd7b1414a
work_keys_str_mv AT manuelhotz pumiliodependentlocalizationofmrnasatthecellfrontcoordinatesmultiplepathwaysrequiredforchemotaxis
AT wjamesnelson pumiliodependentlocalizationofmrnasatthecellfrontcoordinatesmultiplepathwaysrequiredforchemotaxis
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