Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis

Introduction Functional dyspepsia (FD) is typically treated with serotonin receptor (5-HT) agonists such as cisapride, mosapride, tegaserod and tandospirone citrate. However, there are conflicting efficacy data, possibly due to significant heterogeneity between studies. In this meta-analysis, we ana...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Man Jin, Yali Mo, Kaisheng Ye, Mingxian Chen, Yi Liu, Cao He
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2018
Materias:	meta-analysis efficacy functional dyspepsia serotonin receptor placebo Medicine R
Acceso en línea:	https://doaj.org/article/b0e80e8ba0bd41dbae507afc218e8649
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b0e80e8ba0bd41dbae507afc218e8649
record_format	dspace
spelling	oai:doaj.org-article:b0e80e8ba0bd41dbae507afc218e86492021-12-02T18:39:09ZEfficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis1734-19221896-915110.5114/aoms.2017.69234https://doaj.org/article/b0e80e8ba0bd41dbae507afc218e86492018-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Efficacy-of-serotonin-receptor-agonists-in-the-treatment-of-functional-dyspepsia,68204,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Functional dyspepsia (FD) is typically treated with serotonin receptor (5-HT) agonists such as cisapride, mosapride, tegaserod and tandospirone citrate. However, there are conflicting efficacy data, possibly due to significant heterogeneity between studies. In this meta-analysis, we analyzed the efficacy and safety data from studies evaluating the efficacy of serotonin receptor agonists in patients with FD. Material and methods Relevant studies were selected from the Medline, Cochrane, EMBASE, and Google Scholar databases. The meta-analysis included 10 RCTs which evaluated the efficacy of serotonin receptor agonists in patients with FD (final total of 892 patients in the serotonin receptor agonist group, and 640 participants in the placebo group). The primary outcomes were the response rates and abdominal symptoms score. The Cochrane Collaboration’s tool was used to assess risk. Sensitivity analysis was carried out using the leave-one-out approach. Results Patients treated with serotonin receptor agonists had a significantly higher response rate compared to placebo-treated patients (pooled OR = 2.99; 95% CI: 1.15–7.77; p = 0.025). Patients treated with serotonin receptor agonists had a significant improvement in symptom scores compared to the placebo group (pooled standardized mean difference = –0.43; 95% CI: –0.83 to –0.04; p = 0.031). Sensitivity analysis indicated that the pooled estimates for abdominal symptom score might be affected by the Yeoh et al. (1997) study. Conclusions Serotonin receptor agonists had a significantly higher efficacy compared to placebo in the treatment of FD.Man JinYali MoKaisheng YeMingxian ChenYi LiuCao HeTermedia Publishing Housearticlemeta-analysisefficacyfunctional dyspepsiaserotonin receptorplaceboefficacyMedicineRENArchives of Medical Science, Vol 15, Iss 1, Pp 23-32 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	meta-analysis efficacy functional dyspepsia serotonin receptor placebo efficacy Medicine R
spellingShingle	meta-analysis efficacy functional dyspepsia serotonin receptor placebo efficacy Medicine R Man Jin Yali Mo Kaisheng Ye Mingxian Chen Yi Liu Cao He Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis
description	Introduction Functional dyspepsia (FD) is typically treated with serotonin receptor (5-HT) agonists such as cisapride, mosapride, tegaserod and tandospirone citrate. However, there are conflicting efficacy data, possibly due to significant heterogeneity between studies. In this meta-analysis, we analyzed the efficacy and safety data from studies evaluating the efficacy of serotonin receptor agonists in patients with FD. Material and methods Relevant studies were selected from the Medline, Cochrane, EMBASE, and Google Scholar databases. The meta-analysis included 10 RCTs which evaluated the efficacy of serotonin receptor agonists in patients with FD (final total of 892 patients in the serotonin receptor agonist group, and 640 participants in the placebo group). The primary outcomes were the response rates and abdominal symptoms score. The Cochrane Collaboration’s tool was used to assess risk. Sensitivity analysis was carried out using the leave-one-out approach. Results Patients treated with serotonin receptor agonists had a significantly higher response rate compared to placebo-treated patients (pooled OR = 2.99; 95% CI: 1.15–7.77; p = 0.025). Patients treated with serotonin receptor agonists had a significant improvement in symptom scores compared to the placebo group (pooled standardized mean difference = –0.43; 95% CI: –0.83 to –0.04; p = 0.031). Sensitivity analysis indicated that the pooled estimates for abdominal symptom score might be affected by the Yeoh et al. (1997) study. Conclusions Serotonin receptor agonists had a significantly higher efficacy compared to placebo in the treatment of FD.
format	article
author	Man Jin Yali Mo Kaisheng Ye Mingxian Chen Yi Liu Cao He
author_facet	Man Jin Yali Mo Kaisheng Ye Mingxian Chen Yi Liu Cao He
author_sort	Man Jin
title	Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis
title_short	Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis
title_full	Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis
title_fullStr	Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis
title_full_unstemmed	Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis
title_sort	efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis
publisher	Termedia Publishing House
publishDate	2018
url	https://doaj.org/article/b0e80e8ba0bd41dbae507afc218e8649
work_keys_str_mv	AT manjin efficacyofserotoninreceptoragonistsinthetreatmentoffunctionaldyspepsiaametaanalysis AT yalimo efficacyofserotoninreceptoragonistsinthetreatmentoffunctionaldyspepsiaametaanalysis AT kaishengye efficacyofserotoninreceptoragonistsinthetreatmentoffunctionaldyspepsiaametaanalysis AT mingxianchen efficacyofserotoninreceptoragonistsinthetreatmentoffunctionaldyspepsiaametaanalysis AT yiliu efficacyofserotoninreceptoragonistsinthetreatmentoffunctionaldyspepsiaametaanalysis AT caohe efficacyofserotoninreceptoragonistsinthetreatmentoffunctionaldyspepsiaametaanalysis
_version_	1718377760082100224

Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis

Ejemplares similares