A critical role for NF2 and the Hippo pathway in branching morphogenesis

Branching morphogenesis is essential for the formation of most epithelial organs. Here, the authors show that Neurofibromatosis 2 (NF2), the Hippo pathway kinases LATS1 and LATS2, and the transcriptional co-activators YAP and TAZ control tip identity, RET signalling and branching morphogenesis in th...

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Autores principales:	Antoine Reginensi, Leonie Enderle, Alex Gregorieff, Randy L. Johnson, Jeffrey L. Wrana, Helen McNeill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b0ee73c8d77b4a91869ff77ef701be43
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id	oai:doaj.org-article:b0ee73c8d77b4a91869ff77ef701be43
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spelling	oai:doaj.org-article:b0ee73c8d77b4a91869ff77ef701be432021-12-02T17:32:37ZA critical role for NF2 and the Hippo pathway in branching morphogenesis10.1038/ncomms123092041-1723https://doaj.org/article/b0ee73c8d77b4a91869ff77ef701be432016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12309https://doaj.org/toc/2041-1723Branching morphogenesis is essential for the formation of most epithelial organs. Here, the authors show that Neurofibromatosis 2 (NF2), the Hippo pathway kinases LATS1 and LATS2, and the transcriptional co-activators YAP and TAZ control tip identity, RET signalling and branching morphogenesis in the mouse kidney.Antoine ReginensiLeonie EnderleAlex GregorieffRandy L. JohnsonJeffrey L. WranaHelen McNeillNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antoine Reginensi Leonie Enderle Alex Gregorieff Randy L. Johnson Jeffrey L. Wrana Helen McNeill A critical role for NF2 and the Hippo pathway in branching morphogenesis
description	Branching morphogenesis is essential for the formation of most epithelial organs. Here, the authors show that Neurofibromatosis 2 (NF2), the Hippo pathway kinases LATS1 and LATS2, and the transcriptional co-activators YAP and TAZ control tip identity, RET signalling and branching morphogenesis in the mouse kidney.
format	article
author	Antoine Reginensi Leonie Enderle Alex Gregorieff Randy L. Johnson Jeffrey L. Wrana Helen McNeill
author_facet	Antoine Reginensi Leonie Enderle Alex Gregorieff Randy L. Johnson Jeffrey L. Wrana Helen McNeill
author_sort	Antoine Reginensi
title	A critical role for NF2 and the Hippo pathway in branching morphogenesis
title_short	A critical role for NF2 and the Hippo pathway in branching morphogenesis
title_full	A critical role for NF2 and the Hippo pathway in branching morphogenesis
title_fullStr	A critical role for NF2 and the Hippo pathway in branching morphogenesis
title_full_unstemmed	A critical role for NF2 and the Hippo pathway in branching morphogenesis
title_sort	critical role for nf2 and the hippo pathway in branching morphogenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b0ee73c8d77b4a91869ff77ef701be43
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A critical role for NF2 and the Hippo pathway in branching morphogenesis

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