COMPARATIVE STUDY OF ECHINOCHROME A, OXYGENATED CAROTENOIDS, GINSENOSIDE Rh2, LUTEOLIN DISULFATE AND METFORMIN AS A MEAN TO POTENTIATE ANTITUMOR EFFECT OF DOXORUBICIN

This work concerned a comparative study of potentiating effects produced by some drugs of natural origin, as well as metformin, upon antitumor activity of doxorubicin. An increased therapeutic efficacy of doxorubicin used in combination with echinochrome A, oxycarotenoids, ginsenoside Rh2, and metfo...

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Autores principales:	A. V. Tsybulsky, A. M. Popov, A. A. Klimovich, A. A. Artyukov, E. Ya. Kostetsky, M. D. Veselova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	antitumor activity doxorubicin echinochrome a ginsenosides oxygenated carotenoids rh2 luteolin disulfate metformin reactive oxygen species cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b0eee8b6f7264e509ad1afa5228d01b8
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spelling	oai:doaj.org-article:b0eee8b6f7264e509ad1afa5228d01b82021-11-18T08:03:47ZCOMPARATIVE STUDY OF ECHINOCHROME A, OXYGENATED CAROTENOIDS, GINSENOSIDE Rh2, LUTEOLIN DISULFATE AND METFORMIN AS A MEAN TO POTENTIATE ANTITUMOR EFFECT OF DOXORUBICIN1563-06252313-741X10.15789/1563-0625-2018-2-179-192https://doaj.org/article/b0eee8b6f7264e509ad1afa5228d01b82018-03-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1489https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThis work concerned a comparative study of potentiating effects produced by some drugs of natural origin, as well as metformin, upon antitumor activity of doxorubicin. An increased therapeutic efficacy of doxorubicin used in combination with echinochrome A, oxycarotenoids, ginsenoside Rh2, and metformin was tested in the in vivo Ehrlich ascites carcinoma model. The negative effect of luteolin disulfate (10 mg/kg body weight) upon efficacy of antitumor therapy was revealed. When studying the effect of these substances on the level of intracellular ROS in primary cultures of murine spleen cells, using a selective fluorescent indicator (2’,7’-dichlorofluorescein-diacetate), we did not find a positive correlation between induction of excessive ROS synthesis and potentiation of doxorubicin action with the compounds studied. Some of the studied agents showed a positive correlation between interferon-inducing activity, as well as a negative correlation between increased IL-1 content, and higher antitumor effect of doxorubicin. The obtained results suggest expedience of further studies of antitumor effect potentiation using preparations of echinochrome, ginsenoside Rh2, a mixture of oxygenated carotenoids and metformin.A. V. TsybulskyA. M. PopovA. A. KlimovichA. A. ArtyukovE. Ya. KostetskyM. D. VeselovaSPb RAACIarticleantitumor activitydoxorubicinechinochrome aginsenosidesoxygenated carotenoidsrh2luteolin disulfatemetforminreactive oxygen speciescytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 2, Pp 179-192 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	antitumor activity doxorubicin echinochrome a ginsenosides oxygenated carotenoids rh2 luteolin disulfate metformin reactive oxygen species cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	antitumor activity doxorubicin echinochrome a ginsenosides oxygenated carotenoids rh2 luteolin disulfate metformin reactive oxygen species cytokines Immunologic diseases. Allergy RC581-607 A. V. Tsybulsky A. M. Popov A. A. Klimovich A. A. Artyukov E. Ya. Kostetsky M. D. Veselova COMPARATIVE STUDY OF ECHINOCHROME A, OXYGENATED CAROTENOIDS, GINSENOSIDE Rh2, LUTEOLIN DISULFATE AND METFORMIN AS A MEAN TO POTENTIATE ANTITUMOR EFFECT OF DOXORUBICIN
description	This work concerned a comparative study of potentiating effects produced by some drugs of natural origin, as well as metformin, upon antitumor activity of doxorubicin. An increased therapeutic efficacy of doxorubicin used in combination with echinochrome A, oxycarotenoids, ginsenoside Rh2, and metformin was tested in the in vivo Ehrlich ascites carcinoma model. The negative effect of luteolin disulfate (10 mg/kg body weight) upon efficacy of antitumor therapy was revealed. When studying the effect of these substances on the level of intracellular ROS in primary cultures of murine spleen cells, using a selective fluorescent indicator (2’,7’-dichlorofluorescein-diacetate), we did not find a positive correlation between induction of excessive ROS synthesis and potentiation of doxorubicin action with the compounds studied. Some of the studied agents showed a positive correlation between interferon-inducing activity, as well as a negative correlation between increased IL-1 content, and higher antitumor effect of doxorubicin. The obtained results suggest expedience of further studies of antitumor effect potentiation using preparations of echinochrome, ginsenoside Rh2, a mixture of oxygenated carotenoids and metformin.
format	article
author	A. V. Tsybulsky A. M. Popov A. A. Klimovich A. A. Artyukov E. Ya. Kostetsky M. D. Veselova
author_facet	A. V. Tsybulsky A. M. Popov A. A. Klimovich A. A. Artyukov E. Ya. Kostetsky M. D. Veselova
author_sort	A. V. Tsybulsky
title	COMPARATIVE STUDY OF ECHINOCHROME A, OXYGENATED CAROTENOIDS, GINSENOSIDE Rh2, LUTEOLIN DISULFATE AND METFORMIN AS A MEAN TO POTENTIATE ANTITUMOR EFFECT OF DOXORUBICIN
title_short	COMPARATIVE STUDY OF ECHINOCHROME A, OXYGENATED CAROTENOIDS, GINSENOSIDE Rh2, LUTEOLIN DISULFATE AND METFORMIN AS A MEAN TO POTENTIATE ANTITUMOR EFFECT OF DOXORUBICIN
title_full	COMPARATIVE STUDY OF ECHINOCHROME A, OXYGENATED CAROTENOIDS, GINSENOSIDE Rh2, LUTEOLIN DISULFATE AND METFORMIN AS A MEAN TO POTENTIATE ANTITUMOR EFFECT OF DOXORUBICIN
title_fullStr	COMPARATIVE STUDY OF ECHINOCHROME A, OXYGENATED CAROTENOIDS, GINSENOSIDE Rh2, LUTEOLIN DISULFATE AND METFORMIN AS A MEAN TO POTENTIATE ANTITUMOR EFFECT OF DOXORUBICIN
title_full_unstemmed	COMPARATIVE STUDY OF ECHINOCHROME A, OXYGENATED CAROTENOIDS, GINSENOSIDE Rh2, LUTEOLIN DISULFATE AND METFORMIN AS A MEAN TO POTENTIATE ANTITUMOR EFFECT OF DOXORUBICIN
title_sort	comparative study of echinochrome a, oxygenated carotenoids, ginsenoside rh2, luteolin disulfate and metformin as a mean to potentiate antitumor effect of doxorubicin
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/b0eee8b6f7264e509ad1afa5228d01b8
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COMPARATIVE STUDY OF ECHINOCHROME A, OXYGENATED CAROTENOIDS, GINSENOSIDE Rh2, LUTEOLIN DISULFATE AND METFORMIN AS A MEAN TO POTENTIATE ANTITUMOR EFFECT OF DOXORUBICIN

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