Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances

Santanu Ghosh, Kaushik Chatterjee Department of Materials Engineering, Indian Institute of Science, Bangalore, IndiaCorrespondence: Kaushik Chatterjee Tel +91-80-22933408Email kchatterjee@iisc.ac.inAbstract: Owing to the unique physical, chemical, mechanical and electrical properties, graphene and i...

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Autores principales:	Ghosh S, Chatterjee K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	graphene graphene oxide peg poly (ethylene glycol) nanomaterials tissue engineering Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b0f90e798bef4144912034bf2ef895e0
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spelling	oai:doaj.org-article:b0f90e798bef4144912034bf2ef895e02021-12-02T11:08:57ZPoly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances1178-2013https://doaj.org/article/b0f90e798bef4144912034bf2ef895e02020-08-01T00:00:00Zhttps://www.dovepress.com/polyethylene-glycol-functionalized-graphene-oxide-in-tissue-engineerin-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Santanu Ghosh, Kaushik Chatterjee Department of Materials Engineering, Indian Institute of Science, Bangalore, IndiaCorrespondence: Kaushik Chatterjee Tel +91-80-22933408Email kchatterjee@iisc.ac.inAbstract: Owing to the unique physical, chemical, mechanical and electrical properties, graphene and its derivatives have been extensively researched for diverse biomedical applications including in tissue engineering since the past decade. Tunable chemical functionalities of graphene oxide (GO), a graphene derivative, allow easy surface functionalization. Functionalization of GO with poly(ethylene glycol) (PEG) (PEG-GO) has received significant attention as it offers superior solubility, stability, and biocompatibility. Besides being an attractive candidate for drug delivery, PEG-GO can aid in the attachment, proliferation, and differentiation of stem cells, thereby augmenting tissue engineering. PEG-GO has shown excellent antibacterial efficacy, which could be an added advantage to minimize implant-associated infections. This review describes the synthesis techniques, properties, and biological potential of PEG-GO towards mammalian and bacterial cells. Studies wherein these nanomaterials have been explored for engineering various tissues are reviewed along with future opportunities in this field.Keywords: graphene, graphene oxide, PEG, poly(ethylene glycol), nanomaterials, tissue engineeringGhosh SChatterjee KDove Medical Pressarticlegraphenegraphene oxidepegpoly (ethylene glycol)nanomaterialstissue engineeringMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 5991-6006 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	graphene graphene oxide peg poly (ethylene glycol) nanomaterials tissue engineering Medicine (General) R5-920
spellingShingle	graphene graphene oxide peg poly (ethylene glycol) nanomaterials tissue engineering Medicine (General) R5-920 Ghosh S Chatterjee K Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances
description	Santanu Ghosh, Kaushik Chatterjee Department of Materials Engineering, Indian Institute of Science, Bangalore, IndiaCorrespondence: Kaushik Chatterjee Tel +91-80-22933408Email kchatterjee@iisc.ac.inAbstract: Owing to the unique physical, chemical, mechanical and electrical properties, graphene and its derivatives have been extensively researched for diverse biomedical applications including in tissue engineering since the past decade. Tunable chemical functionalities of graphene oxide (GO), a graphene derivative, allow easy surface functionalization. Functionalization of GO with poly(ethylene glycol) (PEG) (PEG-GO) has received significant attention as it offers superior solubility, stability, and biocompatibility. Besides being an attractive candidate for drug delivery, PEG-GO can aid in the attachment, proliferation, and differentiation of stem cells, thereby augmenting tissue engineering. PEG-GO has shown excellent antibacterial efficacy, which could be an added advantage to minimize implant-associated infections. This review describes the synthesis techniques, properties, and biological potential of PEG-GO towards mammalian and bacterial cells. Studies wherein these nanomaterials have been explored for engineering various tissues are reviewed along with future opportunities in this field.Keywords: graphene, graphene oxide, PEG, poly(ethylene glycol), nanomaterials, tissue engineering
format	article
author	Ghosh S Chatterjee K
author_facet	Ghosh S Chatterjee K
author_sort	Ghosh S
title	Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances
title_short	Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances
title_full	Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances
title_fullStr	Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances
title_full_unstemmed	Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances
title_sort	poly(ethylene glycol) functionalized graphene oxide in tissue engineering: a review on recent advances
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/b0f90e798bef4144912034bf2ef895e0
work_keys_str_mv	AT ghoshs polyethyleneglycolfunctionalizedgrapheneoxideintissueengineeringareviewonrecentadvances AT chatterjeek polyethyleneglycolfunctionalizedgrapheneoxideintissueengineeringareviewonrecentadvances
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Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances

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