L-arginine pretreatment ameliorates Lipopolysaccharide-induced thyroid gland dysfunction in male albino rats

Bacterial infection is one of the most common causes of systemic inflammatory syndrome known as sepsis. Previous studies have been shown that sever sepsis was often complicated with secondary multiple organs dysfunction. This syndrome may greatly affect thyroid gland function leading to thyroid g...

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Autores principales:	basma osama mohamed, Hamdy M. Embark Embark
Formato:	article
Lenguaje:	EN
Publicado:	South Valley University 2021
Materias:	: l-arginine lipopolysaccharide t3 t4 tsh Agriculture S Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/b0fa0636163f4860af6ec5f039c5eb6a
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spelling	oai:doaj.org-article:b0fa0636163f4860af6ec5f039c5eb6a2021-12-02T15:50:11ZL-arginine pretreatment ameliorates Lipopolysaccharide-induced thyroid gland dysfunction in male albino rats10.21608/SVU.2021.60533.11042535-18262535-1877https://doaj.org/article/b0fa0636163f4860af6ec5f039c5eb6a2021-05-01T00:00:00Zhttps://svu.journals.ekb.eg/article_173202.htmlhttps://doaj.org/toc/2535-1826https://doaj.org/toc/2535-1877Bacterial infection is one of the most common causes of systemic inflammatory syndrome known as sepsis. Previous studies have been shown that sever sepsis was often complicated with secondary multiple organs dysfunction. This syndrome may greatly affect thyroid gland function leading to thyroid gland dysfunction. The objective of this study was to elucidate the effect of bacterial endotoxin (lipopolysaccharide, LPS) on thyroid gland function. The study extended to investigate the role of L-arginine (L-Arg) as immunomodulator in LPS-induced systemic inflammation. Eighty adults, male Wistar rats were randomly divided into four equal groups: The control group was intraperitoneally (IP) injected with physiological sterile saline (0.9% NaCl at dose 1 ml/kg body weight (BW)); LPS-treated group was injected with a single dose of LPS (1 mg/kg BW, IP); L-Argtreated group was injected with L-Arg (10 mg/kg BW, IP) once per day for 7 consecutive days; and L-Arg + LPS treated group was injected with L-Arg (10 mg/kg BW, IP) once per day for 7 consecutive days followed by a single dose of LPS (1 mg/kg BW, IP). Histopathological changes of thyroid gland, serum triiodothyronine (T3), thyroxine(T4), and thyroid stimulating hormone (TSH) levels were examined at 6, 12, 24 and 72 hours (h) after the last injection. Treatment of rats with a single dose of LPS alone resulted in thyroiditis which manifested by decreased serum T3 and T4 levels and severe necrosis of the thyroid follicles. However, in L-Arg-treated endotoxemic rats, pretreatment with L-Arg attenuated the LPS-induced acute thyroid gland injury. basma osama mohamedHamdy M. Embark EmbarkSouth Valley Universityarticle: l-argininelipopolysaccharidet3t4tshAgricultureSVeterinary medicineSF600-1100ENSVU-International Journal of Veterinary Sciences, Vol 4, Iss 2, Pp 35-50 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	: l-arginine lipopolysaccharide t3 t4 tsh Agriculture S Veterinary medicine SF600-1100
spellingShingle	: l-arginine lipopolysaccharide t3 t4 tsh Agriculture S Veterinary medicine SF600-1100 basma osama mohamed Hamdy M. Embark Embark L-arginine pretreatment ameliorates Lipopolysaccharide-induced thyroid gland dysfunction in male albino rats
description	Bacterial infection is one of the most common causes of systemic inflammatory syndrome known as sepsis. Previous studies have been shown that sever sepsis was often complicated with secondary multiple organs dysfunction. This syndrome may greatly affect thyroid gland function leading to thyroid gland dysfunction. The objective of this study was to elucidate the effect of bacterial endotoxin (lipopolysaccharide, LPS) on thyroid gland function. The study extended to investigate the role of L-arginine (L-Arg) as immunomodulator in LPS-induced systemic inflammation. Eighty adults, male Wistar rats were randomly divided into four equal groups: The control group was intraperitoneally (IP) injected with physiological sterile saline (0.9% NaCl at dose 1 ml/kg body weight (BW)); LPS-treated group was injected with a single dose of LPS (1 mg/kg BW, IP); L-Argtreated group was injected with L-Arg (10 mg/kg BW, IP) once per day for 7 consecutive days; and L-Arg + LPS treated group was injected with L-Arg (10 mg/kg BW, IP) once per day for 7 consecutive days followed by a single dose of LPS (1 mg/kg BW, IP). Histopathological changes of thyroid gland, serum triiodothyronine (T3), thyroxine(T4), and thyroid stimulating hormone (TSH) levels were examined at 6, 12, 24 and 72 hours (h) after the last injection. Treatment of rats with a single dose of LPS alone resulted in thyroiditis which manifested by decreased serum T3 and T4 levels and severe necrosis of the thyroid follicles. However, in L-Arg-treated endotoxemic rats, pretreatment with L-Arg attenuated the LPS-induced acute thyroid gland injury.
format	article
author	basma osama mohamed Hamdy M. Embark Embark
author_facet	basma osama mohamed Hamdy M. Embark Embark
author_sort	basma osama mohamed
title	L-arginine pretreatment ameliorates Lipopolysaccharide-induced thyroid gland dysfunction in male albino rats
title_short	L-arginine pretreatment ameliorates Lipopolysaccharide-induced thyroid gland dysfunction in male albino rats
title_full	L-arginine pretreatment ameliorates Lipopolysaccharide-induced thyroid gland dysfunction in male albino rats
title_fullStr	L-arginine pretreatment ameliorates Lipopolysaccharide-induced thyroid gland dysfunction in male albino rats
title_full_unstemmed	L-arginine pretreatment ameliorates Lipopolysaccharide-induced thyroid gland dysfunction in male albino rats
title_sort	l-arginine pretreatment ameliorates lipopolysaccharide-induced thyroid gland dysfunction in male albino rats
publisher	South Valley University
publishDate	2021
url	https://doaj.org/article/b0fa0636163f4860af6ec5f039c5eb6a
work_keys_str_mv	AT basmaosamamohamed largininepretreatmentameliorateslipopolysaccharideinducedthyroidglanddysfunctioninmalealbinorats AT hamdymembarkembark largininepretreatmentameliorateslipopolysaccharideinducedthyroidglanddysfunctioninmalealbinorats
_version_	1718385712608313344

L-arginine pretreatment ameliorates Lipopolysaccharide-induced thyroid gland dysfunction in male albino rats

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