ROLE OF PAX-5 TRANSCRIPTION FACTOR IN PATHOGENESIS OF BRONCHIAL ASTHMA
Abstract. Expression characteristics of transcription factor PAX-5 (paired box 5) are considered for different clinical variants of bronchial asthma (BA). Low levels of PAX-5 expression may be a reason for progression into a severe allergic asthma, whereas higher levels of PAX-5 expression may repre...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
SPb RAACI
2014
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/b0fc4155ebf34438a729a29bd82452dc |
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| Sumario: | Abstract. Expression characteristics of transcription factor PAX-5 (paired box 5) are considered for different clinical variants of bronchial asthma (BA). Low levels of PAX-5 expression may be a reason for progression into a severe allergic asthma, whereas higher levels of PAX-5 expression may represent a significant factor leading to development of non-allergic bronchial asthma. Initiation of IgE production is supposed to be a less important PAX-5 function in BA pathogenesis, than prevention of B-cell-to-plasmocyte differentiation. Further investigations of PAX-5 properties and its co-operations with other transcription factors may provide a promising path in further research of BA pathogenesis. |
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