ROLE OF PAX-5 TRANSCRIPTION FACTOR IN PATHOGENESIS OF BRONCHIAL ASTHMA

Abstract. Expression characteristics of transcription factor PAX-5 (paired box 5) are considered for different clinical variants of bronchial asthma (BA). Low levels of PAX-5 expression may be a reason for progression into a severe allergic asthma, whereas higher levels of PAX-5 expression may repre...

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Autores principales:	V. N. Mineev, L. N. Sorokina, M. A. Nyoma, G. I. Lipkin, V. A. Ivanov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	bronchial asthma allergy transcription factors pax-5 ige b lymphocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b0fc4155ebf34438a729a29bd82452dc
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spelling	oai:doaj.org-article:b0fc4155ebf34438a729a29bd82452dc2021-11-18T08:03:40ZROLE OF PAX-5 TRANSCRIPTION FACTOR IN PATHOGENESIS OF BRONCHIAL ASTHMA1563-06252313-741X10.15789/1563-0625-2012-4-5-347-352https://doaj.org/article/b0fc4155ebf34438a729a29bd82452dc2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/375https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Expression characteristics of transcription factor PAX-5 (paired box 5) are considered for different clinical variants of bronchial asthma (BA). Low levels of PAX-5 expression may be a reason for progression into a severe allergic asthma, whereas higher levels of PAX-5 expression may represent a significant factor leading to development of non-allergic bronchial asthma. Initiation of IgE production is supposed to be a less important PAX-5 function in BA pathogenesis, than prevention of B-cell-to-plasmocyte differentiation. Further investigations of PAX-5 properties and its co-operations with other transcription factors may provide a promising path in further research of BA pathogenesis.V. N. MineevL. N. SorokinaM. A. NyomaG. I. LipkinV. A. IvanovSPb RAACIarticlebronchial asthmaallergytranscription factorspax-5igeb lymphocytesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 4-5, Pp 347-352 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	bronchial asthma allergy transcription factors pax-5 ige b lymphocytes Immunologic diseases. Allergy RC581-607
spellingShingle	bronchial asthma allergy transcription factors pax-5 ige b lymphocytes Immunologic diseases. Allergy RC581-607 V. N. Mineev L. N. Sorokina M. A. Nyoma G. I. Lipkin V. A. Ivanov ROLE OF PAX-5 TRANSCRIPTION FACTOR IN PATHOGENESIS OF BRONCHIAL ASTHMA
description	Abstract. Expression characteristics of transcription factor PAX-5 (paired box 5) are considered for different clinical variants of bronchial asthma (BA). Low levels of PAX-5 expression may be a reason for progression into a severe allergic asthma, whereas higher levels of PAX-5 expression may represent a significant factor leading to development of non-allergic bronchial asthma. Initiation of IgE production is supposed to be a less important PAX-5 function in BA pathogenesis, than prevention of B-cell-to-plasmocyte differentiation. Further investigations of PAX-5 properties and its co-operations with other transcription factors may provide a promising path in further research of BA pathogenesis.
format	article
author	V. N. Mineev L. N. Sorokina M. A. Nyoma G. I. Lipkin V. A. Ivanov
author_facet	V. N. Mineev L. N. Sorokina M. A. Nyoma G. I. Lipkin V. A. Ivanov
author_sort	V. N. Mineev
title	ROLE OF PAX-5 TRANSCRIPTION FACTOR IN PATHOGENESIS OF BRONCHIAL ASTHMA
title_short	ROLE OF PAX-5 TRANSCRIPTION FACTOR IN PATHOGENESIS OF BRONCHIAL ASTHMA
title_full	ROLE OF PAX-5 TRANSCRIPTION FACTOR IN PATHOGENESIS OF BRONCHIAL ASTHMA
title_fullStr	ROLE OF PAX-5 TRANSCRIPTION FACTOR IN PATHOGENESIS OF BRONCHIAL ASTHMA
title_full_unstemmed	ROLE OF PAX-5 TRANSCRIPTION FACTOR IN PATHOGENESIS OF BRONCHIAL ASTHMA
title_sort	role of pax-5 transcription factor in pathogenesis of bronchial asthma
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b0fc4155ebf34438a729a29bd82452dc
work_keys_str_mv	AT vnmineev roleofpax5transcriptionfactorinpathogenesisofbronchialasthma AT lnsorokina roleofpax5transcriptionfactorinpathogenesisofbronchialasthma AT manyoma roleofpax5transcriptionfactorinpathogenesisofbronchialasthma AT gilipkin roleofpax5transcriptionfactorinpathogenesisofbronchialasthma AT vaivanov roleofpax5transcriptionfactorinpathogenesisofbronchialasthma
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ROLE OF PAX-5 TRANSCRIPTION FACTOR IN PATHOGENESIS OF BRONCHIAL ASTHMA

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