Crystal structure of human METTL6, the m3C methyltransferase

Ran Chen et al. report the crystal structure of human m3C methyltrasfease METTL6. They generate structure models of hMETTL6 in complex with substrates, providing important insight into the molecular recognition mechanism by METTL6 and may aid in the METTL-based rational drug design in the future.

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Autores principales: Ran Chen, Jie Zhou, Ling Liu, Xue-Ling Mao, Xiaolong Zhou, Wei Xie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b0fe700029b24643a4a01b21bcf67940
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spelling oai:doaj.org-article:b0fe700029b24643a4a01b21bcf679402021-12-05T12:08:17ZCrystal structure of human METTL6, the m3C methyltransferase10.1038/s42003-021-02890-92399-3642https://doaj.org/article/b0fe700029b24643a4a01b21bcf679402021-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02890-9https://doaj.org/toc/2399-3642Ran Chen et al. report the crystal structure of human m3C methyltrasfease METTL6. They generate structure models of hMETTL6 in complex with substrates, providing important insight into the molecular recognition mechanism by METTL6 and may aid in the METTL-based rational drug design in the future.Ran ChenJie ZhouLing LiuXue-Ling MaoXiaolong ZhouWei XieNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Ran Chen
Jie Zhou
Ling Liu
Xue-Ling Mao
Xiaolong Zhou
Wei Xie
Crystal structure of human METTL6, the m3C methyltransferase
description Ran Chen et al. report the crystal structure of human m3C methyltrasfease METTL6. They generate structure models of hMETTL6 in complex with substrates, providing important insight into the molecular recognition mechanism by METTL6 and may aid in the METTL-based rational drug design in the future.
format article
author Ran Chen
Jie Zhou
Ling Liu
Xue-Ling Mao
Xiaolong Zhou
Wei Xie
author_facet Ran Chen
Jie Zhou
Ling Liu
Xue-Ling Mao
Xiaolong Zhou
Wei Xie
author_sort Ran Chen
title Crystal structure of human METTL6, the m3C methyltransferase
title_short Crystal structure of human METTL6, the m3C methyltransferase
title_full Crystal structure of human METTL6, the m3C methyltransferase
title_fullStr Crystal structure of human METTL6, the m3C methyltransferase
title_full_unstemmed Crystal structure of human METTL6, the m3C methyltransferase
title_sort crystal structure of human mettl6, the m3c methyltransferase
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b0fe700029b24643a4a01b21bcf67940
work_keys_str_mv AT ranchen crystalstructureofhumanmettl6them3cmethyltransferase
AT jiezhou crystalstructureofhumanmettl6them3cmethyltransferase
AT lingliu crystalstructureofhumanmettl6them3cmethyltransferase
AT xuelingmao crystalstructureofhumanmettl6them3cmethyltransferase
AT xiaolongzhou crystalstructureofhumanmettl6them3cmethyltransferase
AT weixie crystalstructureofhumanmettl6them3cmethyltransferase
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