Crystal structure of human METTL6, the m3C methyltransferase
Ran Chen et al. report the crystal structure of human m3C methyltrasfease METTL6. They generate structure models of hMETTL6 in complex with substrates, providing important insight into the molecular recognition mechanism by METTL6 and may aid in the METTL-based rational drug design in the future.
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Nature Portfolio
2021
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oai:doaj.org-article:b0fe700029b24643a4a01b21bcf679402021-12-05T12:08:17ZCrystal structure of human METTL6, the m3C methyltransferase10.1038/s42003-021-02890-92399-3642https://doaj.org/article/b0fe700029b24643a4a01b21bcf679402021-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02890-9https://doaj.org/toc/2399-3642Ran Chen et al. report the crystal structure of human m3C methyltrasfease METTL6. They generate structure models of hMETTL6 in complex with substrates, providing important insight into the molecular recognition mechanism by METTL6 and may aid in the METTL-based rational drug design in the future.Ran ChenJie ZhouLing LiuXue-Ling MaoXiaolong ZhouWei XieNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021) |
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Biology (General) QH301-705.5 |
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Biology (General) QH301-705.5 Ran Chen Jie Zhou Ling Liu Xue-Ling Mao Xiaolong Zhou Wei Xie Crystal structure of human METTL6, the m3C methyltransferase |
description |
Ran Chen et al. report the crystal structure of human m3C methyltrasfease METTL6. They generate structure models of hMETTL6 in complex with substrates, providing important insight into the molecular recognition mechanism by METTL6 and may aid in the METTL-based rational drug design in the future. |
format |
article |
author |
Ran Chen Jie Zhou Ling Liu Xue-Ling Mao Xiaolong Zhou Wei Xie |
author_facet |
Ran Chen Jie Zhou Ling Liu Xue-Ling Mao Xiaolong Zhou Wei Xie |
author_sort |
Ran Chen |
title |
Crystal structure of human METTL6, the m3C methyltransferase |
title_short |
Crystal structure of human METTL6, the m3C methyltransferase |
title_full |
Crystal structure of human METTL6, the m3C methyltransferase |
title_fullStr |
Crystal structure of human METTL6, the m3C methyltransferase |
title_full_unstemmed |
Crystal structure of human METTL6, the m3C methyltransferase |
title_sort |
crystal structure of human mettl6, the m3c methyltransferase |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/b0fe700029b24643a4a01b21bcf67940 |
work_keys_str_mv |
AT ranchen crystalstructureofhumanmettl6them3cmethyltransferase AT jiezhou crystalstructureofhumanmettl6them3cmethyltransferase AT lingliu crystalstructureofhumanmettl6them3cmethyltransferase AT xuelingmao crystalstructureofhumanmettl6them3cmethyltransferase AT xiaolongzhou crystalstructureofhumanmettl6them3cmethyltransferase AT weixie crystalstructureofhumanmettl6them3cmethyltransferase |
_version_ |
1718372213712748544 |