Crystal structure of human METTL6, the m3C methyltransferase

Ran Chen et al. report the crystal structure of human m3C methyltrasfease METTL6. They generate structure models of hMETTL6 in complex with substrates, providing important insight into the molecular recognition mechanism by METTL6 and may aid in the METTL-based rational drug design in the future.

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Bibliographic Details
Main Authors:	Ran Chen, Jie Zhou, Ling Liu, Xue-Ling Mao, Xiaolong Zhou, Wei Xie
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/b0fe700029b24643a4a01b21bcf67940
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spelling	oai:doaj.org-article:b0fe700029b24643a4a01b21bcf679402021-12-05T12:08:17ZCrystal structure of human METTL6, the m3C methyltransferase10.1038/s42003-021-02890-92399-3642https://doaj.org/article/b0fe700029b24643a4a01b21bcf679402021-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02890-9https://doaj.org/toc/2399-3642Ran Chen et al. report the crystal structure of human m3C methyltrasfease METTL6. They generate structure models of hMETTL6 in complex with substrates, providing important insight into the molecular recognition mechanism by METTL6 and may aid in the METTL-based rational drug design in the future.Ran ChenJie ZhouLing LiuXue-Ling MaoXiaolong ZhouWei XieNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ran Chen Jie Zhou Ling Liu Xue-Ling Mao Xiaolong Zhou Wei Xie Crystal structure of human METTL6, the m3C methyltransferase
description	Ran Chen et al. report the crystal structure of human m3C methyltrasfease METTL6. They generate structure models of hMETTL6 in complex with substrates, providing important insight into the molecular recognition mechanism by METTL6 and may aid in the METTL-based rational drug design in the future.
format	article
author	Ran Chen Jie Zhou Ling Liu Xue-Ling Mao Xiaolong Zhou Wei Xie
author_facet	Ran Chen Jie Zhou Ling Liu Xue-Ling Mao Xiaolong Zhou Wei Xie
author_sort	Ran Chen
title	Crystal structure of human METTL6, the m3C methyltransferase
title_short	Crystal structure of human METTL6, the m3C methyltransferase
title_full	Crystal structure of human METTL6, the m3C methyltransferase
title_fullStr	Crystal structure of human METTL6, the m3C methyltransferase
title_full_unstemmed	Crystal structure of human METTL6, the m3C methyltransferase
title_sort	crystal structure of human mettl6, the m3c methyltransferase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b0fe700029b24643a4a01b21bcf67940
work_keys_str_mv	AT ranchen crystalstructureofhumanmettl6them3cmethyltransferase AT jiezhou crystalstructureofhumanmettl6them3cmethyltransferase AT lingliu crystalstructureofhumanmettl6them3cmethyltransferase AT xuelingmao crystalstructureofhumanmettl6them3cmethyltransferase AT xiaolongzhou crystalstructureofhumanmettl6them3cmethyltransferase AT weixie crystalstructureofhumanmettl6them3cmethyltransferase
_version_	1718372213712748544

Crystal structure of human METTL6, the m3C methyltransferase

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