PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS

Objective: To assess the outcome and complications of plasmapharesis in treatment of myasthenia gravis and factors linked to poor outcome at hematology unit of a tertiary care teaching hospital of Pakistan Study Design: Prospective comparative study. Place and Duration of Study: Pak Emirates M...

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Autores principales:	Maryam Abbas, Helen Mary Robert, Asad Mahmood, Saleem Ahmed Khan, Mohammad Abdul Naeem, Muhammad Ahsan Ayaz
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	myasthenia gravis outcome plasmapharesis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b10387d243634c198306d91e478aa9fb
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spelling	oai:doaj.org-article:b10387d243634c198306d91e478aa9fb2021-12-02T18:01:40ZPLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS0030-96482411-884210.51253/pafmj.v71i2.4024https://doaj.org/article/b10387d243634c198306d91e478aa9fb2021-04-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/4024https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To assess the outcome and complications of plasmapharesis in treatment of myasthenia gravis and factors linked to poor outcome at hematology unit of a tertiary care teaching hospital of Pakistan Study Design: Prospective comparative study. Place and Duration of Study: Pak Emirates Military Hospital/Armed Forces Institute of Pathology, Rawalpindi, from Jan 2018 to Jul 2019. Methodology: A prospective study was conducted on patients of myasthenia gravis presented at our neurology department. All the complications of the procedure were recorded. Outcomes included recovery, shifting to intensive care unit and death. Pearson chi-square was applied to relate the factors with presence of complications or poor outcome. Results: Hypotension 3 (6%) was the commonest complication faced by the patients followed by chest discomfort 2 (4%) during or after the plasmapharesis. Out of 50 patients, 47 (94%) recovered, 8 (16%) had minor complications, 2 (4%) were shifted to the intensive care unit and 1 (2%) died. Long duration of time between onset of symptoms and first session of plasmapharesis had a significant relationship (p-value <0.05) with presence of complications or poor outcome among the patients of myasthenia gravis undergoing plasmapharesis. Conclusion: Plasmapharesis emerged as effective treatment for this immune based neurological disorder with limited side effects. A neurologist should be aware of these common minor and rare major side effects and pay special attention to the patients with generalized myasthenia gravis and those with long duration of time between onset of symptoms and first session of plasmapharesis. Keywords: ,.Maryam AbbasHelen Mary RobertAsad MahmoodSaleem Ahmed KhanMohammad Abdul NaeemMuhammad Ahsan AyazArmy Medical College Rawalpindiarticlemyasthenia gravisoutcomeplasmapharesisMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 2, Pp 396-400 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	myasthenia gravis outcome plasmapharesis Medicine R Medicine (General) R5-920
spellingShingle	myasthenia gravis outcome plasmapharesis Medicine R Medicine (General) R5-920 Maryam Abbas Helen Mary Robert Asad Mahmood Saleem Ahmed Khan Mohammad Abdul Naeem Muhammad Ahsan Ayaz PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS
description	Objective: To assess the outcome and complications of plasmapharesis in treatment of myasthenia gravis and factors linked to poor outcome at hematology unit of a tertiary care teaching hospital of Pakistan Study Design: Prospective comparative study. Place and Duration of Study: Pak Emirates Military Hospital/Armed Forces Institute of Pathology, Rawalpindi, from Jan 2018 to Jul 2019. Methodology: A prospective study was conducted on patients of myasthenia gravis presented at our neurology department. All the complications of the procedure were recorded. Outcomes included recovery, shifting to intensive care unit and death. Pearson chi-square was applied to relate the factors with presence of complications or poor outcome. Results: Hypotension 3 (6%) was the commonest complication faced by the patients followed by chest discomfort 2 (4%) during or after the plasmapharesis. Out of 50 patients, 47 (94%) recovered, 8 (16%) had minor complications, 2 (4%) were shifted to the intensive care unit and 1 (2%) died. Long duration of time between onset of symptoms and first session of plasmapharesis had a significant relationship (p-value <0.05) with presence of complications or poor outcome among the patients of myasthenia gravis undergoing plasmapharesis. Conclusion: Plasmapharesis emerged as effective treatment for this immune based neurological disorder with limited side effects. A neurologist should be aware of these common minor and rare major side effects and pay special attention to the patients with generalized myasthenia gravis and those with long duration of time between onset of symptoms and first session of plasmapharesis. Keywords: ,.
format	article
author	Maryam Abbas Helen Mary Robert Asad Mahmood Saleem Ahmed Khan Mohammad Abdul Naeem Muhammad Ahsan Ayaz
author_facet	Maryam Abbas Helen Mary Robert Asad Mahmood Saleem Ahmed Khan Mohammad Abdul Naeem Muhammad Ahsan Ayaz
author_sort	Maryam Abbas
title	PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS
title_short	PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS
title_full	PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS
title_fullStr	PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS
title_full_unstemmed	PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS
title_sort	plasmapheresis in the treatment of myasthenia gravis: outcome and complications
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/b10387d243634c198306d91e478aa9fb
work_keys_str_mv	AT maryamabbas plasmapheresisinthetreatmentofmyastheniagravisoutcomeandcomplications AT helenmaryrobert plasmapheresisinthetreatmentofmyastheniagravisoutcomeandcomplications AT asadmahmood plasmapheresisinthetreatmentofmyastheniagravisoutcomeandcomplications AT saleemahmedkhan plasmapheresisinthetreatmentofmyastheniagravisoutcomeandcomplications AT mohammadabdulnaeem plasmapheresisinthetreatmentofmyastheniagravisoutcomeandcomplications AT muhammadahsanayaz plasmapheresisinthetreatmentofmyastheniagravisoutcomeandcomplications
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PLASMAPHERESIS IN THE TREATMENT OF MYASTHENIA GRAVIS: OUTCOME AND COMPLICATIONS

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