Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the development of collagen h...

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Autores principales:	Pablo Edmundo Antezana, Sofia Municoy, Claudio Javier Pérez, Martin Federico Desimone
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	collagen biomaterials silver nanoparticles <i>Cannabis sativa</i> wound healing antimicrobial Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/b104515aeab64124be0cab2c190eddca
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spelling	oai:doaj.org-article:b104515aeab64124be0cab2c190eddca2021-11-25T16:25:09ZCollagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil10.3390/antibiotics101114202079-6382https://doaj.org/article/b104515aeab64124be0cab2c190eddca2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1420https://doaj.org/toc/2079-6382Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the development of collagen hydrogels loaded with silver nanoparticles and <i>Cannabis sativa</i> oil extract is described. The presence of the silver nanoparticles gives interesting feature to the biomaterial such as improved mechanical properties or resistance to collagenase degradation but most important is the long-lasting antimicrobial effect. <i>Cannabis sativa</i> oil, which is known for its anti-inflammatory and analgesic effects, possesses antioxidant activity and successfully improved the biocompatibility and also enhances the antimicrobial activity of the nanocomposite. Altogether, these results suggest that this novel nanocomposite biomaterial is a promising alternative to common treatments of wound infections and wound healing.Pablo Edmundo AntezanaSofia MunicoyClaudio Javier PérezMartin Federico DesimoneMDPI AGarticlecollagenbiomaterialssilver nanoparticles<i>Cannabis sativa</i>wound healingantimicrobialTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1420, p 1420 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	collagen biomaterials silver nanoparticles <i>Cannabis sativa</i> wound healing antimicrobial Therapeutics. Pharmacology RM1-950
spellingShingle	collagen biomaterials silver nanoparticles <i>Cannabis sativa</i> wound healing antimicrobial Therapeutics. Pharmacology RM1-950 Pablo Edmundo Antezana Sofia Municoy Claudio Javier Pérez Martin Federico Desimone Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil
description	Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the development of collagen hydrogels loaded with silver nanoparticles and <i>Cannabis sativa</i> oil extract is described. The presence of the silver nanoparticles gives interesting feature to the biomaterial such as improved mechanical properties or resistance to collagenase degradation but most important is the long-lasting antimicrobial effect. <i>Cannabis sativa</i> oil, which is known for its anti-inflammatory and analgesic effects, possesses antioxidant activity and successfully improved the biocompatibility and also enhances the antimicrobial activity of the nanocomposite. Altogether, these results suggest that this novel nanocomposite biomaterial is a promising alternative to common treatments of wound infections and wound healing.
format	article
author	Pablo Edmundo Antezana Sofia Municoy Claudio Javier Pérez Martin Federico Desimone
author_facet	Pablo Edmundo Antezana Sofia Municoy Claudio Javier Pérez Martin Federico Desimone
author_sort	Pablo Edmundo Antezana
title	Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil
title_short	Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil
title_full	Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil
title_fullStr	Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil
title_full_unstemmed	Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil
title_sort	collagen hydrogels loaded with silver nanoparticles and cannabis sativa oil
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b104515aeab64124be0cab2c190eddca
work_keys_str_mv	AT pabloedmundoantezana collagenhydrogelsloadedwithsilvernanoparticlesandcannabissativaoil AT sofiamunicoy collagenhydrogelsloadedwithsilvernanoparticlesandcannabissativaoil AT claudiojavierperez collagenhydrogelsloadedwithsilvernanoparticlesandcannabissativaoil AT martinfedericodesimone collagenhydrogelsloadedwithsilvernanoparticlesandcannabissativaoil
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Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

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