Neurovascular coupling and bilateral connectivity during NREM and REM sleep

To understand how arousal state impacts cerebral hemodynamics and neurovascular coupling, we monitored neural activity, behavior, and hemodynamic signals in un-anesthetized, head-fixed mice. Mice frequently fell asleep during imaging, and these sleep events were interspersed with periods of wake. Du...

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Autores principales:	Kevin L Turner, Kyle W Gheres, Elizabeth A Proctor, Patrick J Drew
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2020
Materias:	neurovascular coupling sleep optical imaging electrophysiology 2-photon microscopy arousal state Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b1084424140845b8ab55522cce149d2b
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spelling	oai:doaj.org-article:b1084424140845b8ab55522cce149d2b2021-11-22T14:41:54ZNeurovascular coupling and bilateral connectivity during NREM and REM sleep10.7554/eLife.620712050-084Xe62071https://doaj.org/article/b1084424140845b8ab55522cce149d2b2020-10-01T00:00:00Zhttps://elifesciences.org/articles/62071https://doaj.org/toc/2050-084XTo understand how arousal state impacts cerebral hemodynamics and neurovascular coupling, we monitored neural activity, behavior, and hemodynamic signals in un-anesthetized, head-fixed mice. Mice frequently fell asleep during imaging, and these sleep events were interspersed with periods of wake. During both NREM and REM sleep, mice showed large increases in cerebral blood volume ([HbT]) and arteriole diameter relative to the awake state, two to five times larger than those evoked by sensory stimulation. During NREM, the amplitude of bilateral low-frequency oscillations in [HbT] increased markedly, and coherency between neural activity and hemodynamic signals was higher than the awake resting and REM states. Bilateral correlations in neural activity and [HbT] were highest during NREM, and lowest in the awake state. Hemodynamic signals in the cortex are strongly modulated by arousal state, and changes during sleep are substantially larger than sensory-evoked responses.Kevin L TurnerKyle W GheresElizabeth A ProctorPatrick J DreweLife Sciences Publications Ltdarticleneurovascular couplingsleepoptical imagingelectrophysiology2-photon microscopyarousal stateMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurovascular coupling sleep optical imaging electrophysiology 2-photon microscopy arousal state Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	neurovascular coupling sleep optical imaging electrophysiology 2-photon microscopy arousal state Medicine R Science Q Biology (General) QH301-705.5 Kevin L Turner Kyle W Gheres Elizabeth A Proctor Patrick J Drew Neurovascular coupling and bilateral connectivity during NREM and REM sleep
description	To understand how arousal state impacts cerebral hemodynamics and neurovascular coupling, we monitored neural activity, behavior, and hemodynamic signals in un-anesthetized, head-fixed mice. Mice frequently fell asleep during imaging, and these sleep events were interspersed with periods of wake. During both NREM and REM sleep, mice showed large increases in cerebral blood volume ([HbT]) and arteriole diameter relative to the awake state, two to five times larger than those evoked by sensory stimulation. During NREM, the amplitude of bilateral low-frequency oscillations in [HbT] increased markedly, and coherency between neural activity and hemodynamic signals was higher than the awake resting and REM states. Bilateral correlations in neural activity and [HbT] were highest during NREM, and lowest in the awake state. Hemodynamic signals in the cortex are strongly modulated by arousal state, and changes during sleep are substantially larger than sensory-evoked responses.
format	article
author	Kevin L Turner Kyle W Gheres Elizabeth A Proctor Patrick J Drew
author_facet	Kevin L Turner Kyle W Gheres Elizabeth A Proctor Patrick J Drew
author_sort	Kevin L Turner
title	Neurovascular coupling and bilateral connectivity during NREM and REM sleep
title_short	Neurovascular coupling and bilateral connectivity during NREM and REM sleep
title_full	Neurovascular coupling and bilateral connectivity during NREM and REM sleep
title_fullStr	Neurovascular coupling and bilateral connectivity during NREM and REM sleep
title_full_unstemmed	Neurovascular coupling and bilateral connectivity during NREM and REM sleep
title_sort	neurovascular coupling and bilateral connectivity during nrem and rem sleep
publisher	eLife Sciences Publications Ltd
publishDate	2020
url	https://doaj.org/article/b1084424140845b8ab55522cce149d2b
work_keys_str_mv	AT kevinlturner neurovascularcouplingandbilateralconnectivityduringnremandremsleep AT kylewgheres neurovascularcouplingandbilateralconnectivityduringnremandremsleep AT elizabethaproctor neurovascularcouplingandbilateralconnectivityduringnremandremsleep AT patrickjdrew neurovascularcouplingandbilateralconnectivityduringnremandremsleep
_version_	1718417574591463424

Neurovascular coupling and bilateral connectivity during NREM and REM sleep

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