Incidental prostate cancer at the time of cystectomy: the incidence and clinicopathological features in Chinese patients.

<h4>Objectives</h4>To evaluate the incidence and the clinicopathological features of incidental prostate cancer detected in radical cystoprostatectomy (RCP) specimens in Chinese men and to estimate the oncological risk of prostate apex-sparing surgery for such patients.<h4>Methods&...

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Autores principales:	Jiahua Pan, Wei Xue, Jianjun Sha, Hu Yang, Fan Xu, Hanqing Xuan, Dong Li, Yiran Huang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b10f6315e0614ab8837734523523cb15
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spelling	oai:doaj.org-article:b10f6315e0614ab8837734523523cb152021-11-18T08:23:50ZIncidental prostate cancer at the time of cystectomy: the incidence and clinicopathological features in Chinese patients.1932-620310.1371/journal.pone.0094490https://doaj.org/article/b10f6315e0614ab8837734523523cb152014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24722643/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>To evaluate the incidence and the clinicopathological features of incidental prostate cancer detected in radical cystoprostatectomy (RCP) specimens in Chinese men and to estimate the oncological risk of prostate apex-sparing surgery for such patients.<h4>Methods</h4>The clinical data and pathological feature of 504 patients who underwent RCP for bladder cancer from January 1999 to March 2013 were retrospectively reviewed. Whole mount serial section of the RCP specimens were cut transversely at 3-4 mm intervals and examined in same pathological institution.<h4>Results</h4>Thirty-four out of 504 patients (6.8%) had incidental prostate cancer with a mean age of 70.3 years. 12 cases (35.2%) were diagnosed as significant disease. 4 cases were found to have apex involvement of adenocarcinoma of the prostate while in 5 cases the prostate stroma invasion by urothelial carcinoma were identified (one involved prostate apex). The mean follow-up time was 46.4±33.8 months. Biochemical recurrence occurred in 3 patients but no prostate cancer-related death during the follow-up. There was no statistical significance in cancer specific survival between the clinically significant and insignificant cancer group.<h4>Conclusions</h4>The prevalence of incidental prostate cancer in RCP specimens in Chinese patients was remarkably lower than in western people. Most of the incidental prostate cancer was clinically insignificant and patient's prognosis was mainly related to the bladder cancer. Sparing the prostate apex was potentially associated with a 1.0% risk of leaving significant cancer of the prostate or urothelial carcinoma.Jiahua PanWei XueJianjun ShaHu YangFan XuHanqing XuanDong LiYiran HuangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e94490 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiahua Pan Wei Xue Jianjun Sha Hu Yang Fan Xu Hanqing Xuan Dong Li Yiran Huang Incidental prostate cancer at the time of cystectomy: the incidence and clinicopathological features in Chinese patients.
description	<h4>Objectives</h4>To evaluate the incidence and the clinicopathological features of incidental prostate cancer detected in radical cystoprostatectomy (RCP) specimens in Chinese men and to estimate the oncological risk of prostate apex-sparing surgery for such patients.<h4>Methods</h4>The clinical data and pathological feature of 504 patients who underwent RCP for bladder cancer from January 1999 to March 2013 were retrospectively reviewed. Whole mount serial section of the RCP specimens were cut transversely at 3-4 mm intervals and examined in same pathological institution.<h4>Results</h4>Thirty-four out of 504 patients (6.8%) had incidental prostate cancer with a mean age of 70.3 years. 12 cases (35.2%) were diagnosed as significant disease. 4 cases were found to have apex involvement of adenocarcinoma of the prostate while in 5 cases the prostate stroma invasion by urothelial carcinoma were identified (one involved prostate apex). The mean follow-up time was 46.4±33.8 months. Biochemical recurrence occurred in 3 patients but no prostate cancer-related death during the follow-up. There was no statistical significance in cancer specific survival between the clinically significant and insignificant cancer group.<h4>Conclusions</h4>The prevalence of incidental prostate cancer in RCP specimens in Chinese patients was remarkably lower than in western people. Most of the incidental prostate cancer was clinically insignificant and patient's prognosis was mainly related to the bladder cancer. Sparing the prostate apex was potentially associated with a 1.0% risk of leaving significant cancer of the prostate or urothelial carcinoma.
format	article
author	Jiahua Pan Wei Xue Jianjun Sha Hu Yang Fan Xu Hanqing Xuan Dong Li Yiran Huang
author_facet	Jiahua Pan Wei Xue Jianjun Sha Hu Yang Fan Xu Hanqing Xuan Dong Li Yiran Huang
author_sort	Jiahua Pan
title	Incidental prostate cancer at the time of cystectomy: the incidence and clinicopathological features in Chinese patients.
title_short	Incidental prostate cancer at the time of cystectomy: the incidence and clinicopathological features in Chinese patients.
title_full	Incidental prostate cancer at the time of cystectomy: the incidence and clinicopathological features in Chinese patients.
title_fullStr	Incidental prostate cancer at the time of cystectomy: the incidence and clinicopathological features in Chinese patients.
title_full_unstemmed	Incidental prostate cancer at the time of cystectomy: the incidence and clinicopathological features in Chinese patients.
title_sort	incidental prostate cancer at the time of cystectomy: the incidence and clinicopathological features in chinese patients.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/b10f6315e0614ab8837734523523cb15
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Incidental prostate cancer at the time of cystectomy: the incidence and clinicopathological features in Chinese patients.

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