Ultrasound-enhanced biosynthesis of uniform ZnO nanorice using Swietenia macrophylla seed extract and its in vitro anticancer activity

In this study, ultrasonically driven biosynthesis of zinc oxide nanoparticles (ZnO NPs) using Swietenia macrophylla seed ethyl acetate fraction (SMEAF) has been reported. X-ray powder diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) analyses confirmed the presence of a pure hexag...

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Autores principales:	Low Darren Yi Sern, Mahendra Camille Keisha, Supramaniam Janarthanan, Tan Loh Teng Hern, Lee Learn Han, Manickam Sivakumar, Goh Bey Hing, Tan Khang Wei, Tang Siah Ying
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	ultrasound biosynthesis zno nps swietenia macrophylla anticancer Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
Acceso en línea:	https://doaj.org/article/b110de5ed47145108d03d34b7a7dccfc
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spelling	oai:doaj.org-article:b110de5ed47145108d03d34b7a7dccfc2021-12-05T14:10:57ZUltrasound-enhanced biosynthesis of uniform ZnO nanorice using Swietenia macrophylla seed extract and its in vitro anticancer activity2191-909710.1515/ntrev-2021-0044https://doaj.org/article/b110de5ed47145108d03d34b7a7dccfc2021-06-01T00:00:00Zhttps://doi.org/10.1515/ntrev-2021-0044https://doaj.org/toc/2191-9097In this study, ultrasonically driven biosynthesis of zinc oxide nanoparticles (ZnO NPs) using Swietenia macrophylla seed ethyl acetate fraction (SMEAF) has been reported. X-ray powder diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) analyses confirmed the presence of a pure hexagonal wurtzite structure of ZnO. Field emission scanning electron microscope images revealed the formation of uniquely identifiable uniform rice-shaped biologically synthesized ZnOSMEAF particles. The particle sizes of the biosynthesized NPs ranged from 262 to 311 nm. The underlying mechanisms for the biosynthesis of ZnOSMEAF under ultrasound have been proposed based on FTIR and XRD results. The anticancer activity of the as-prepared ZnOSMEAF was investigated against HCT-116 human colon cancer cell lines via methyl thiazolyl tetrazolium assay. ZnOSMEAF exhibited significant anticancer activity against colon cancer cells with higher potency than ZnO particles prepared using the chemical method and SMEAF alone. Exposure of HCT-116 colon cancer cells to ZnOSMEAF promoted a remarkable reduction in cell viability in all the tested concentrations. This study suggests that green sonochemically induced ZnO NPs using medicinal plant extract could be a potential anticancer agent for biomedical applications.Low Darren Yi SernMahendra Camille KeishaSupramaniam JanarthananTan Loh Teng HernLee Learn HanManickam SivakumarGoh Bey HingTan Khang WeiTang Siah YingDe Gruyterarticleultrasoundbiosynthesisznonpsswietenia macrophyllaanticancerTechnologyTChemical technologyTP1-1185Physical and theoretical chemistryQD450-801ENNanotechnology Reviews, Vol 10, Iss 1, Pp 572-585 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ultrasound biosynthesis zno nps swietenia macrophylla anticancer Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
spellingShingle	ultrasound biosynthesis zno nps swietenia macrophylla anticancer Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801 Low Darren Yi Sern Mahendra Camille Keisha Supramaniam Janarthanan Tan Loh Teng Hern Lee Learn Han Manickam Sivakumar Goh Bey Hing Tan Khang Wei Tang Siah Ying Ultrasound-enhanced biosynthesis of uniform ZnO nanorice using Swietenia macrophylla seed extract and its in vitro anticancer activity
description	In this study, ultrasonically driven biosynthesis of zinc oxide nanoparticles (ZnO NPs) using Swietenia macrophylla seed ethyl acetate fraction (SMEAF) has been reported. X-ray powder diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) analyses confirmed the presence of a pure hexagonal wurtzite structure of ZnO. Field emission scanning electron microscope images revealed the formation of uniquely identifiable uniform rice-shaped biologically synthesized ZnOSMEAF particles. The particle sizes of the biosynthesized NPs ranged from 262 to 311 nm. The underlying mechanisms for the biosynthesis of ZnOSMEAF under ultrasound have been proposed based on FTIR and XRD results. The anticancer activity of the as-prepared ZnOSMEAF was investigated against HCT-116 human colon cancer cell lines via methyl thiazolyl tetrazolium assay. ZnOSMEAF exhibited significant anticancer activity against colon cancer cells with higher potency than ZnO particles prepared using the chemical method and SMEAF alone. Exposure of HCT-116 colon cancer cells to ZnOSMEAF promoted a remarkable reduction in cell viability in all the tested concentrations. This study suggests that green sonochemically induced ZnO NPs using medicinal plant extract could be a potential anticancer agent for biomedical applications.
format	article
author	Low Darren Yi Sern Mahendra Camille Keisha Supramaniam Janarthanan Tan Loh Teng Hern Lee Learn Han Manickam Sivakumar Goh Bey Hing Tan Khang Wei Tang Siah Ying
author_facet	Low Darren Yi Sern Mahendra Camille Keisha Supramaniam Janarthanan Tan Loh Teng Hern Lee Learn Han Manickam Sivakumar Goh Bey Hing Tan Khang Wei Tang Siah Ying
author_sort	Low Darren Yi Sern
title	Ultrasound-enhanced biosynthesis of uniform ZnO nanorice using Swietenia macrophylla seed extract and its in vitro anticancer activity
title_short	Ultrasound-enhanced biosynthesis of uniform ZnO nanorice using Swietenia macrophylla seed extract and its in vitro anticancer activity
title_full	Ultrasound-enhanced biosynthesis of uniform ZnO nanorice using Swietenia macrophylla seed extract and its in vitro anticancer activity
title_fullStr	Ultrasound-enhanced biosynthesis of uniform ZnO nanorice using Swietenia macrophylla seed extract and its in vitro anticancer activity
title_full_unstemmed	Ultrasound-enhanced biosynthesis of uniform ZnO nanorice using Swietenia macrophylla seed extract and its in vitro anticancer activity
title_sort	ultrasound-enhanced biosynthesis of uniform zno nanorice using swietenia macrophylla seed extract and its in vitro anticancer activity
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/b110de5ed47145108d03d34b7a7dccfc
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Ultrasound-enhanced biosynthesis of uniform ZnO nanorice using Swietenia macrophylla seed extract and its in vitro anticancer activity

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