MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors

Not all mutated cells become malignant, suggesting additional requirements for transformation. Here, the authors track blood progenitors from normal to malignancy driven by MLL-AF9, revealing a subset of myeloid progenitors predisposed to transformation dependent on their normal cycling state.

Guardado en:

Detalles Bibliográficos
Autores principales:	Xinyue Chen, Daniel B. Burkhardt, Amaleah A. Hartman, Xiao Hu, Anna E. Eastman, Chao Sun, Xujun Wang, Mei Zhong, Smita Krishnaswamy, Shangqin Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b111a4d94fc0407fb663f8993929840c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b111a4d94fc0407fb663f8993929840c
record_format	dspace
spelling	oai:doaj.org-article:b111a4d94fc0407fb663f8993929840c2021-12-02T17:01:28ZMLL-AF9 initiates transformation from fast-proliferating myeloid progenitors10.1038/s41467-019-13666-52041-1723https://doaj.org/article/b111a4d94fc0407fb663f8993929840c2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13666-5https://doaj.org/toc/2041-1723Not all mutated cells become malignant, suggesting additional requirements for transformation. Here, the authors track blood progenitors from normal to malignancy driven by MLL-AF9, revealing a subset of myeloid progenitors predisposed to transformation dependent on their normal cycling state.Xinyue ChenDaniel B. BurkhardtAmaleah A. HartmanXiao HuAnna E. EastmanChao SunXujun WangMei ZhongSmita KrishnaswamyShangqin GuoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xinyue Chen Daniel B. Burkhardt Amaleah A. Hartman Xiao Hu Anna E. Eastman Chao Sun Xujun Wang Mei Zhong Smita Krishnaswamy Shangqin Guo MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
description	Not all mutated cells become malignant, suggesting additional requirements for transformation. Here, the authors track blood progenitors from normal to malignancy driven by MLL-AF9, revealing a subset of myeloid progenitors predisposed to transformation dependent on their normal cycling state.
format	article
author	Xinyue Chen Daniel B. Burkhardt Amaleah A. Hartman Xiao Hu Anna E. Eastman Chao Sun Xujun Wang Mei Zhong Smita Krishnaswamy Shangqin Guo
author_facet	Xinyue Chen Daniel B. Burkhardt Amaleah A. Hartman Xiao Hu Anna E. Eastman Chao Sun Xujun Wang Mei Zhong Smita Krishnaswamy Shangqin Guo
author_sort	Xinyue Chen
title	MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
title_short	MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
title_full	MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
title_fullStr	MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
title_full_unstemmed	MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
title_sort	mll-af9 initiates transformation from fast-proliferating myeloid progenitors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b111a4d94fc0407fb663f8993929840c
work_keys_str_mv	AT xinyuechen mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT danielbburkhardt mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT amaleahahartman mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT xiaohu mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT annaeeastman mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT chaosun mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT xujunwang mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT meizhong mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT smitakrishnaswamy mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors AT shangqinguo mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors
_version_	1718382169675530240

MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors

Ejemplares similares