MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors

MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors

Not all mutated cells become malignant, suggesting additional requirements for transformation. Here, the authors track blood progenitors from normal to malignancy driven by MLL-AF9, revealing a subset of myeloid progenitors predisposed to transformation dependent on their normal cycling state.

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Detalles Bibliográficos
Autores principales: Xinyue Chen, Daniel B. Burkhardt, Amaleah A. Hartman, Xiao Hu, Anna E. Eastman, Chao Sun, Xujun Wang, Mei Zhong, Smita Krishnaswamy, Shangqin Guo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/b111a4d94fc0407fb663f8993929840c
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