TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

The protein cGAS responds to the presence of cytosolic DNA by producing the second messenger cGAMP, which triggers antiviral interferon responses. Here, Seo et al. show that ubiquitination by the E3 ligase TRIM56 enhances cGAS activity and is important for the immune response against DNA viruses.

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Bibliographic Details
Main Authors:	Gil Ju Seo, Charlotte Kim, Woo-Jin Shin, Ella H. Sklan, Hyungjin Eoh, Jae U. Jung
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/b1125f70e5b14f2e994da6473f8ed289
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spelling	oai:doaj.org-article:b1125f70e5b14f2e994da6473f8ed2892021-12-02T16:56:41ZTRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing10.1038/s41467-018-02936-32041-1723https://doaj.org/article/b1125f70e5b14f2e994da6473f8ed2892018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02936-3https://doaj.org/toc/2041-1723The protein cGAS responds to the presence of cytosolic DNA by producing the second messenger cGAMP, which triggers antiviral interferon responses. Here, Seo et al. show that ubiquitination by the E3 ligase TRIM56 enhances cGAS activity and is important for the immune response against DNA viruses.Gil Ju SeoCharlotte KimWoo-Jin ShinElla H. SklanHyungjin EohJae U. JungNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gil Ju Seo Charlotte Kim Woo-Jin Shin Ella H. Sklan Hyungjin Eoh Jae U. Jung TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
description	The protein cGAS responds to the presence of cytosolic DNA by producing the second messenger cGAMP, which triggers antiviral interferon responses. Here, Seo et al. show that ubiquitination by the E3 ligase TRIM56 enhances cGAS activity and is important for the immune response against DNA viruses.
format	article
author	Gil Ju Seo Charlotte Kim Woo-Jin Shin Ella H. Sklan Hyungjin Eoh Jae U. Jung
author_facet	Gil Ju Seo Charlotte Kim Woo-Jin Shin Ella H. Sklan Hyungjin Eoh Jae U. Jung
author_sort	Gil Ju Seo
title	TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
title_short	TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
title_full	TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
title_fullStr	TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
title_full_unstemmed	TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
title_sort	trim56-mediated monoubiquitination of cgas for cytosolic dna sensing
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b1125f70e5b14f2e994da6473f8ed289
work_keys_str_mv	AT giljuseo trim56mediatedmonoubiquitinationofcgasforcytosolicdnasensing AT charlottekim trim56mediatedmonoubiquitinationofcgasforcytosolicdnasensing AT woojinshin trim56mediatedmonoubiquitinationofcgasforcytosolicdnasensing AT ellahsklan trim56mediatedmonoubiquitinationofcgasforcytosolicdnasensing AT hyungjineoh trim56mediatedmonoubiquitinationofcgasforcytosolicdnasensing AT jaeujung trim56mediatedmonoubiquitinationofcgasforcytosolicdnasensing
_version_	1718382762250993664

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

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