pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release

Wen-Yu Qian,1,* Dong-Mei Sun,1,* Rong-Rong Zhu,1 Xi-Ling Du,1 Hui Liu,2 Shi-Long Wang11Shanghai Tenth People&#39;s Hospital, School of Life Science and Technology, Tongji University, Shanghai, PR China; 2Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, PR...

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Autores principales:	Wang SL, Liu H, Du XL, Zhu RR, Sun DM, Qian WY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b11280cf93994505a1c12460dfa89297
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spelling	oai:doaj.org-article:b11280cf93994505a1c12460dfa892972021-12-02T01:13:02ZpH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release1176-91141178-2013https://doaj.org/article/b11280cf93994505a1c12460dfa892972012-11-01T00:00:00Zhttp://www.dovepress.com/ph-sensitive-strontium-carbonate-nanoparticles-as-new-anticancer-vehic-a11563https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Wen-Yu Qian,1,* Dong-Mei Sun,1,* Rong-Rong Zhu,1 Xi-Ling Du,1 Hui Liu,2 Shi-Long Wang11Shanghai Tenth People&#39;s Hospital, School of Life Science and Technology, Tongji University, Shanghai, PR China; 2Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, PR China*Wen-Yu Qian and Dong-Mei Sun contributed equally to this workAbstract: Strontium carbonate nanoparticles (SCNs), a novel biodegradable nanosystem for the pH-sensitive release of anticancer drugs, were developed via a facile mixed solvent method aimed at creating smart drug delivery in acidic conditions, particularly in tumor environments. Structural characterization of SCNs revealed that the engineered nanocarriers were uniform in size and presented a dumbbell-shaped morphology with a dense mass of a scale-like spine coating, which could serve as the storage structure for hydrophobic drugs. Chosen as a model anticancer agent, etoposide was effectively loaded into SCNs based on a simultaneous process that allowed for the formation of the nanocarriers and for drug storage to be accomplished in a single step. The etoposide-loaded SCNs (ESCNs) possess both a high loading capacity and efficient encapsulation. It was found that the cumulative release of etoposide from ESCNs is acid-dependent, and that the release rate is slow at a pH of 7.4; this rate increases significantly at low pH levels (5.8, 3.0). Meanwhile, it was also found that the blank SCNs were almost nontoxic to normal cells, and ESCN systems were evidently more potent in antitumor activity compared with free etoposide, as confirmed by a cytotoxicity test using an MTT assay and an apoptosis test with fluorescence-activated cell sorter (FACS) analysis. These findings suggest that SCNs hold tremendous promise in the areas of controlled drug delivery and targeted cancer therapy.Keywords: strontium carbonate, nanoparticles, pH-sensitive drug delivery, etoposide, anticancer activityWang SLLiu HDu XLZhu RRSun DMQian WYDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 5781-5792 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wang SL Liu H Du XL Zhu RR Sun DM Qian WY pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release
description	Wen-Yu Qian,1,* Dong-Mei Sun,1,* Rong-Rong Zhu,1 Xi-Ling Du,1 Hui Liu,2 Shi-Long Wang11Shanghai Tenth People&#39;s Hospital, School of Life Science and Technology, Tongji University, Shanghai, PR China; 2Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, PR China*Wen-Yu Qian and Dong-Mei Sun contributed equally to this workAbstract: Strontium carbonate nanoparticles (SCNs), a novel biodegradable nanosystem for the pH-sensitive release of anticancer drugs, were developed via a facile mixed solvent method aimed at creating smart drug delivery in acidic conditions, particularly in tumor environments. Structural characterization of SCNs revealed that the engineered nanocarriers were uniform in size and presented a dumbbell-shaped morphology with a dense mass of a scale-like spine coating, which could serve as the storage structure for hydrophobic drugs. Chosen as a model anticancer agent, etoposide was effectively loaded into SCNs based on a simultaneous process that allowed for the formation of the nanocarriers and for drug storage to be accomplished in a single step. The etoposide-loaded SCNs (ESCNs) possess both a high loading capacity and efficient encapsulation. It was found that the cumulative release of etoposide from ESCNs is acid-dependent, and that the release rate is slow at a pH of 7.4; this rate increases significantly at low pH levels (5.8, 3.0). Meanwhile, it was also found that the blank SCNs were almost nontoxic to normal cells, and ESCN systems were evidently more potent in antitumor activity compared with free etoposide, as confirmed by a cytotoxicity test using an MTT assay and an apoptosis test with fluorescence-activated cell sorter (FACS) analysis. These findings suggest that SCNs hold tremendous promise in the areas of controlled drug delivery and targeted cancer therapy.Keywords: strontium carbonate, nanoparticles, pH-sensitive drug delivery, etoposide, anticancer activity
format	article
author	Wang SL Liu H Du XL Zhu RR Sun DM Qian WY
author_facet	Wang SL Liu H Du XL Zhu RR Sun DM Qian WY
author_sort	Wang SL
title	pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release
title_short	pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release
title_full	pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release
title_fullStr	pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release
title_full_unstemmed	pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release
title_sort	ph-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/b11280cf93994505a1c12460dfa89297
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pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release

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