Recombination modulates how selection affects linked sites in Drosophila.

One of the most influential observations in molecular evolution has been a strong association between local recombination rate and nucleotide polymorphisms across the genome. This is interpreted as evidence for ubiquitous natural selection. The alternative explanation, that recombination is mutageni...

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Autores principales:	Suzanne E McGaugh, Caiti S S Heil, Brenda Manzano-Winkler, Laurence Loewe, Steve Goldstein, Tiffany L Himmel, Mohamed A F Noor
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b1181c25c90e4ef0be0af9c238c5fbc5
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spelling	oai:doaj.org-article:b1181c25c90e4ef0be0af9c238c5fbc52021-11-18T05:37:22ZRecombination modulates how selection affects linked sites in Drosophila.1544-91731545-788510.1371/journal.pbio.1001422https://doaj.org/article/b1181c25c90e4ef0be0af9c238c5fbc52012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23152720/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885One of the most influential observations in molecular evolution has been a strong association between local recombination rate and nucleotide polymorphisms across the genome. This is interpreted as evidence for ubiquitous natural selection. The alternative explanation, that recombination is mutagenic, has been rejected by the absence of a similar association between local recombination rate and nucleotide divergence between species. However, many recent studies show that recombination rates are often very different even in closely related species, questioning whether an association between recombination rate and divergence between species has been tested satisfactorily. To circumvent this problem, we directly surveyed recombination across approximately 43% of the D. pseudoobscura physical genome in two separate recombination maps and 31% of the D. miranda physical genome, and we identified both global and local differences in recombination rate between these two closely related species. Using only regions with conserved recombination rates between and within species and accounting for multiple covariates, our data support the conclusion that recombination is positively related to diversity because recombination modulates Hill-Robertson effects in the genome and not because recombination is predominately mutagenic. Finally, we find evidence for dips in diversity around nonsynonymous substitutions. We infer that at least some of this reduction in diversity resulted from selective sweeps and examine these dips in the context of recombination rate.Suzanne E McGaughCaiti S S HeilBrenda Manzano-WinklerLaurence LoeweSteve GoldsteinTiffany L HimmelMohamed A F NoorPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 10, Iss 11, p e1001422 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Suzanne E McGaugh Caiti S S Heil Brenda Manzano-Winkler Laurence Loewe Steve Goldstein Tiffany L Himmel Mohamed A F Noor Recombination modulates how selection affects linked sites in Drosophila.
description	One of the most influential observations in molecular evolution has been a strong association between local recombination rate and nucleotide polymorphisms across the genome. This is interpreted as evidence for ubiquitous natural selection. The alternative explanation, that recombination is mutagenic, has been rejected by the absence of a similar association between local recombination rate and nucleotide divergence between species. However, many recent studies show that recombination rates are often very different even in closely related species, questioning whether an association between recombination rate and divergence between species has been tested satisfactorily. To circumvent this problem, we directly surveyed recombination across approximately 43% of the D. pseudoobscura physical genome in two separate recombination maps and 31% of the D. miranda physical genome, and we identified both global and local differences in recombination rate between these two closely related species. Using only regions with conserved recombination rates between and within species and accounting for multiple covariates, our data support the conclusion that recombination is positively related to diversity because recombination modulates Hill-Robertson effects in the genome and not because recombination is predominately mutagenic. Finally, we find evidence for dips in diversity around nonsynonymous substitutions. We infer that at least some of this reduction in diversity resulted from selective sweeps and examine these dips in the context of recombination rate.
format	article
author	Suzanne E McGaugh Caiti S S Heil Brenda Manzano-Winkler Laurence Loewe Steve Goldstein Tiffany L Himmel Mohamed A F Noor
author_facet	Suzanne E McGaugh Caiti S S Heil Brenda Manzano-Winkler Laurence Loewe Steve Goldstein Tiffany L Himmel Mohamed A F Noor
author_sort	Suzanne E McGaugh
title	Recombination modulates how selection affects linked sites in Drosophila.
title_short	Recombination modulates how selection affects linked sites in Drosophila.
title_full	Recombination modulates how selection affects linked sites in Drosophila.
title_fullStr	Recombination modulates how selection affects linked sites in Drosophila.
title_full_unstemmed	Recombination modulates how selection affects linked sites in Drosophila.
title_sort	recombination modulates how selection affects linked sites in drosophila.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/b1181c25c90e4ef0be0af9c238c5fbc5
work_keys_str_mv	AT suzanneemcgaugh recombinationmodulateshowselectionaffectslinkedsitesindrosophila AT caitissheil recombinationmodulateshowselectionaffectslinkedsitesindrosophila AT brendamanzanowinkler recombinationmodulateshowselectionaffectslinkedsitesindrosophila AT laurenceloewe recombinationmodulateshowselectionaffectslinkedsitesindrosophila AT stevegoldstein recombinationmodulateshowselectionaffectslinkedsitesindrosophila AT tiffanylhimmel recombinationmodulateshowselectionaffectslinkedsitesindrosophila AT mohamedafnoor recombinationmodulateshowselectionaffectslinkedsitesindrosophila
_version_	1718424872870215680

Recombination modulates how selection affects linked sites in Drosophila.

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