Radiogenomics: Hunting Down Liver Metastasis in Colorectal Cancer Patients

Radiomics is a developing new discipline that analyzes conventional medical images to extract quantifiable data that can be mined for new biomarkers that show the biology of pathological processes at microscopic levels. These data can be converted into image-based signatures to improve diagnostic, p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Carolina de la Pinta, María E. Castillo, Manuel Collado, Cristina Galindo-Pumariño, Cristina Peña
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	colon cancer liver metastasis radiogenomics radiomics metastatic niche early detection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b11bf368625044e68e33049eca505cf6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b11bf368625044e68e33049eca505cf6
record_format	dspace
spelling	oai:doaj.org-article:b11bf368625044e68e33049eca505cf62021-11-11T15:34:31ZRadiogenomics: Hunting Down Liver Metastasis in Colorectal Cancer Patients10.3390/cancers132155472072-6694https://doaj.org/article/b11bf368625044e68e33049eca505cf62021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5547https://doaj.org/toc/2072-6694Radiomics is a developing new discipline that analyzes conventional medical images to extract quantifiable data that can be mined for new biomarkers that show the biology of pathological processes at microscopic levels. These data can be converted into image-based signatures to improve diagnostic, prognostic and predictive accuracy in cancer patients. The combination of radiomics and molecular data, called radiogenomics, has clear implications for cancer patients’ management. Though some studies have focused on radiogenomics signatures in hepatocellular carcinoma patients, only a few have examined colorectal cancer metastatic lesions in the liver. Moreover, the need to differentiate between liver lesions is fundamental for accurate diagnosis and treatment. In this review, we summarize the knowledge gained from radiomics and radiogenomics studies in hepatic metastatic colorectal cancer patients and their use in early diagnosis, response assessment and treatment decisions. We also investigate their value as possible prognostic biomarkers. In addition, the great potential of image mining to provide a comprehensive view of liver niche formation is examined thoroughly. Finally, new challenges and current limitations for the early detection of the liver premetastatic niche, based on radiomics and radiogenomics, are also discussed.Carolina de la PintaMaría E. CastilloManuel ColladoCristina Galindo-PumariñoCristina PeñaMDPI AGarticlecolon cancerliver metastasisradiogenomicsradiomicsmetastatic nicheearly detectionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5547, p 5547 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colon cancer liver metastasis radiogenomics radiomics metastatic niche early detection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	colon cancer liver metastasis radiogenomics radiomics metastatic niche early detection Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Carolina de la Pinta María E. Castillo Manuel Collado Cristina Galindo-Pumariño Cristina Peña Radiogenomics: Hunting Down Liver Metastasis in Colorectal Cancer Patients
description	Radiomics is a developing new discipline that analyzes conventional medical images to extract quantifiable data that can be mined for new biomarkers that show the biology of pathological processes at microscopic levels. These data can be converted into image-based signatures to improve diagnostic, prognostic and predictive accuracy in cancer patients. The combination of radiomics and molecular data, called radiogenomics, has clear implications for cancer patients’ management. Though some studies have focused on radiogenomics signatures in hepatocellular carcinoma patients, only a few have examined colorectal cancer metastatic lesions in the liver. Moreover, the need to differentiate between liver lesions is fundamental for accurate diagnosis and treatment. In this review, we summarize the knowledge gained from radiomics and radiogenomics studies in hepatic metastatic colorectal cancer patients and their use in early diagnosis, response assessment and treatment decisions. We also investigate their value as possible prognostic biomarkers. In addition, the great potential of image mining to provide a comprehensive view of liver niche formation is examined thoroughly. Finally, new challenges and current limitations for the early detection of the liver premetastatic niche, based on radiomics and radiogenomics, are also discussed.
format	article
author	Carolina de la Pinta María E. Castillo Manuel Collado Cristina Galindo-Pumariño Cristina Peña
author_facet	Carolina de la Pinta María E. Castillo Manuel Collado Cristina Galindo-Pumariño Cristina Peña
author_sort	Carolina de la Pinta
title	Radiogenomics: Hunting Down Liver Metastasis in Colorectal Cancer Patients
title_short	Radiogenomics: Hunting Down Liver Metastasis in Colorectal Cancer Patients
title_full	Radiogenomics: Hunting Down Liver Metastasis in Colorectal Cancer Patients
title_fullStr	Radiogenomics: Hunting Down Liver Metastasis in Colorectal Cancer Patients
title_full_unstemmed	Radiogenomics: Hunting Down Liver Metastasis in Colorectal Cancer Patients
title_sort	radiogenomics: hunting down liver metastasis in colorectal cancer patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b11bf368625044e68e33049eca505cf6
work_keys_str_mv	AT carolinadelapinta radiogenomicshuntingdownlivermetastasisincolorectalcancerpatients AT mariaecastillo radiogenomicshuntingdownlivermetastasisincolorectalcancerpatients AT manuelcollado radiogenomicshuntingdownlivermetastasisincolorectalcancerpatients AT cristinagalindopumarino radiogenomicshuntingdownlivermetastasisincolorectalcancerpatients AT cristinapena radiogenomicshuntingdownlivermetastasisincolorectalcancerpatients
_version_	1718435205288558592

Radiogenomics: Hunting Down Liver Metastasis in Colorectal Cancer Patients

Ejemplares similares