Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway

Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway

mRNAs export from the nucleus is thought to be regulated in part by three nucleoporins that comprise the nuclear basket, but whether and how distinct basket nucleoporins interact with the RNA export machinery is unclear. Here, the authors use rapid auxin-mediated degradation of basket nucleoporins N...

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Autores principales: Vasilisa Aksenova, Alexandra Smith, Hangnoh Lee, Prasanna Bhat, Caroline Esnault, Shane Chen, James Iben, Ross Kaufhold, Ka Chun Yau, Carlos Echeverria, Beatriz Fontoura, Alexei Arnaoutov, Mary Dasso
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b11e933a22b94f5d92aa8aec90845e1b
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spelling oai:doaj.org-article:b11e933a22b94f5d92aa8aec90845e1b2021-12-02T19:12:30ZNucleoporin TPR is an integral component of the TREX-2 mRNA export pathway10.1038/s41467-020-18266-22041-1723https://doaj.org/article/b11e933a22b94f5d92aa8aec90845e1b2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18266-2https://doaj.org/toc/2041-1723mRNAs export from the nucleus is thought to be regulated in part by three nucleoporins that comprise the nuclear basket, but whether and how distinct basket nucleoporins interact with the RNA export machinery is unclear. Here, the authors use rapid auxin-mediated degradation of basket nucleoporins Nup153, Nup50, and Tpr, and see that Tpr interacts with the TREX-2 mRNA export complex.Vasilisa AksenovaAlexandra SmithHangnoh LeePrasanna BhatCaroline EsnaultShane ChenJames IbenRoss KaufholdKa Chun YauCarlos EcheverriaBeatriz FontouraAlexei ArnaoutovMary DassoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Vasilisa Aksenova
Alexandra Smith
Hangnoh Lee
Prasanna Bhat
Caroline Esnault
Shane Chen
James Iben
Ross Kaufhold
Ka Chun Yau
Carlos Echeverria
Beatriz Fontoura
Alexei Arnaoutov
Mary Dasso
Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway
description mRNAs export from the nucleus is thought to be regulated in part by three nucleoporins that comprise the nuclear basket, but whether and how distinct basket nucleoporins interact with the RNA export machinery is unclear. Here, the authors use rapid auxin-mediated degradation of basket nucleoporins Nup153, Nup50, and Tpr, and see that Tpr interacts with the TREX-2 mRNA export complex.
format article
author Vasilisa Aksenova
Alexandra Smith
Hangnoh Lee
Prasanna Bhat
Caroline Esnault
Shane Chen
James Iben
Ross Kaufhold
Ka Chun Yau
Carlos Echeverria
Beatriz Fontoura
Alexei Arnaoutov
Mary Dasso
author_facet Vasilisa Aksenova
Alexandra Smith
Hangnoh Lee
Prasanna Bhat
Caroline Esnault
Shane Chen
James Iben
Ross Kaufhold
Ka Chun Yau
Carlos Echeverria
Beatriz Fontoura
Alexei Arnaoutov
Mary Dasso
author_sort Vasilisa Aksenova
title Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway
title_short Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway
title_full Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway
title_fullStr Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway
title_full_unstemmed Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway
title_sort nucleoporin tpr is an integral component of the trex-2 mrna export pathway
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/b11e933a22b94f5d92aa8aec90845e1b
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