The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus

Abstract Dioxins are highly toxic to foetuses and prenatal exposure leads to adverse health effects; however, the metabolic pathways involved in dioxin excretion are poorly understood. We determined the dynamics of maternal-to-foetal dioxin transfer during normal pregnancy and how foetuses eliminate...

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Autores principales:	Seiichi Morokuma, Kiyomi Tsukimori, Tsuguhide Hori, Kiyoko Kato, Masutaka Furue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b11edf4da90046c483fca726bf0fe530
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spelling	oai:doaj.org-article:b11edf4da90046c483fca726bf0fe5302021-12-02T11:52:35ZThe Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus10.1038/s41598-017-00863-92045-2322https://doaj.org/article/b11edf4da90046c483fca726bf0fe5302017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00863-9https://doaj.org/toc/2045-2322Abstract Dioxins are highly toxic to foetuses and prenatal exposure leads to adverse health effects; however, the metabolic pathways involved in dioxin excretion are poorly understood. We determined the dynamics of maternal-to-foetal dioxin transfer during normal pregnancy and how foetuses eliminate polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and non-ortho polychlorinated biphenyls. Dioxin levels in maternal blood, cord blood, placenta, vernix caseosa, meconium, and amniotic fluid were analysed by high-resolution gas chromatography/mass spectrometry. The average levels of total dioxins, expressed as picograms of toxic equivalency quantity per gram of lipid and in parentheses, dioxin fraction, with maternal blood levels arbitrarily set as 100%, were as follows: maternal blood, 15.8 (100%); placenta, 12.9 (81.5%); cord blood, 5.9 (37.2%); vernix caseosa, 8.4 (53.2%); meconium, 2.9 (18.2%); and amniotic fluid, 1.5 (9.2%). Similar proportions were observed for each dioxin congener. Thus, the highest content of foetal dioxins was observed in the vernix caseosa, indicating that this is the major site of dioxin excretion in human foetuses.Seiichi MorokumaKiyomi TsukimoriTsuguhide HoriKiyoko KatoMasutaka FurueNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-4 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seiichi Morokuma Kiyomi Tsukimori Tsuguhide Hori Kiyoko Kato Masutaka Furue The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus
description	Abstract Dioxins are highly toxic to foetuses and prenatal exposure leads to adverse health effects; however, the metabolic pathways involved in dioxin excretion are poorly understood. We determined the dynamics of maternal-to-foetal dioxin transfer during normal pregnancy and how foetuses eliminate polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and non-ortho polychlorinated biphenyls. Dioxin levels in maternal blood, cord blood, placenta, vernix caseosa, meconium, and amniotic fluid were analysed by high-resolution gas chromatography/mass spectrometry. The average levels of total dioxins, expressed as picograms of toxic equivalency quantity per gram of lipid and in parentheses, dioxin fraction, with maternal blood levels arbitrarily set as 100%, were as follows: maternal blood, 15.8 (100%); placenta, 12.9 (81.5%); cord blood, 5.9 (37.2%); vernix caseosa, 8.4 (53.2%); meconium, 2.9 (18.2%); and amniotic fluid, 1.5 (9.2%). Similar proportions were observed for each dioxin congener. Thus, the highest content of foetal dioxins was observed in the vernix caseosa, indicating that this is the major site of dioxin excretion in human foetuses.
format	article
author	Seiichi Morokuma Kiyomi Tsukimori Tsuguhide Hori Kiyoko Kato Masutaka Furue
author_facet	Seiichi Morokuma Kiyomi Tsukimori Tsuguhide Hori Kiyoko Kato Masutaka Furue
author_sort	Seiichi Morokuma
title	The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus
title_short	The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus
title_full	The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus
title_fullStr	The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus
title_full_unstemmed	The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus
title_sort	vernix caseosa is the main site of dioxin excretion in the human foetus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b11edf4da90046c483fca726bf0fe530
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The Vernix Caseosa is the Main Site of Dioxin Excretion in the Human Foetus

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