Immunoglobulin G expression in lung cancer and its effects on metastasis.

Lung cancer is one of the leading malignancies worldwide, but the regulatory mechanism of its growth and metastasis is still poorly understood. We investigated the possible expression of immunoglobulin G (IgG) genes in squamous cell carcinomas and adenocarcinomas of the lung and related cancer cell...

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Autores principales:	Chunfan Jiang, Tao Huang, Yun Wang, Guowei Huang, Xia Wan, Jiang Gu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b11ff9437bbd4842b56a0970a285ed15
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spelling	oai:doaj.org-article:b11ff9437bbd4842b56a0970a285ed152021-11-18T08:18:16ZImmunoglobulin G expression in lung cancer and its effects on metastasis.1932-620310.1371/journal.pone.0097359https://doaj.org/article/b11ff9437bbd4842b56a0970a285ed152014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24853685/?tool=EBIhttps://doaj.org/toc/1932-6203Lung cancer is one of the leading malignancies worldwide, but the regulatory mechanism of its growth and metastasis is still poorly understood. We investigated the possible expression of immunoglobulin G (IgG) genes in squamous cell carcinomas and adenocarcinomas of the lung and related cancer cell lines. Abundant mRNA of IgG and essential enzymes for IgG synthesis, recombination activation genes 1, 2 (RAG1, 2) and activation-induced cytidine deaminase (AID) were detected in the cancer cells but not in adjacent normal lung tissue or normal lung epithelial cell line. The extents of IgG expression in 86 lung cancers were found to associate with clinical stage, pathological grade and lymph node metastasis. We found that knockdown of IgG with siRNA resulted in decreases of cellular proliferation, migration and attachment for cultured lung cancer cells. Metastasis-associated gene 1 (MTA1) appeared to be co-expressed with IgG in lung cancer cells. Statistical analysis showed that the rate of IgG expression was significantly correlated to that of MTA1 and to lymph node metastases. Inhibition of MTA1 gene expression with siRNA also led to decreases of cellular migration and attachment for cultured lung cancer cells. These evidences suggested that inhibition of cancer migration and attachment induced by IgG down-regulation might be achieved through MTA1 regulatory pathway. Our findings suggest that lung cancer-produced IgG is likely to play an important role in cancer growth and metastasis with significant clinical implications.Chunfan JiangTao HuangYun WangGuowei HuangXia WanJiang GuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97359 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chunfan Jiang Tao Huang Yun Wang Guowei Huang Xia Wan Jiang Gu Immunoglobulin G expression in lung cancer and its effects on metastasis.
description	Lung cancer is one of the leading malignancies worldwide, but the regulatory mechanism of its growth and metastasis is still poorly understood. We investigated the possible expression of immunoglobulin G (IgG) genes in squamous cell carcinomas and adenocarcinomas of the lung and related cancer cell lines. Abundant mRNA of IgG and essential enzymes for IgG synthesis, recombination activation genes 1, 2 (RAG1, 2) and activation-induced cytidine deaminase (AID) were detected in the cancer cells but not in adjacent normal lung tissue or normal lung epithelial cell line. The extents of IgG expression in 86 lung cancers were found to associate with clinical stage, pathological grade and lymph node metastasis. We found that knockdown of IgG with siRNA resulted in decreases of cellular proliferation, migration and attachment for cultured lung cancer cells. Metastasis-associated gene 1 (MTA1) appeared to be co-expressed with IgG in lung cancer cells. Statistical analysis showed that the rate of IgG expression was significantly correlated to that of MTA1 and to lymph node metastases. Inhibition of MTA1 gene expression with siRNA also led to decreases of cellular migration and attachment for cultured lung cancer cells. These evidences suggested that inhibition of cancer migration and attachment induced by IgG down-regulation might be achieved through MTA1 regulatory pathway. Our findings suggest that lung cancer-produced IgG is likely to play an important role in cancer growth and metastasis with significant clinical implications.
format	article
author	Chunfan Jiang Tao Huang Yun Wang Guowei Huang Xia Wan Jiang Gu
author_facet	Chunfan Jiang Tao Huang Yun Wang Guowei Huang Xia Wan Jiang Gu
author_sort	Chunfan Jiang
title	Immunoglobulin G expression in lung cancer and its effects on metastasis.
title_short	Immunoglobulin G expression in lung cancer and its effects on metastasis.
title_full	Immunoglobulin G expression in lung cancer and its effects on metastasis.
title_fullStr	Immunoglobulin G expression in lung cancer and its effects on metastasis.
title_full_unstemmed	Immunoglobulin G expression in lung cancer and its effects on metastasis.
title_sort	immunoglobulin g expression in lung cancer and its effects on metastasis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/b11ff9437bbd4842b56a0970a285ed15
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Immunoglobulin G expression in lung cancer and its effects on metastasis.

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