Age at first birth in women is genetically associated with increased risk of schizophrenia

Abstract Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at fi...

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Autores principales:	Guiyan Ni, Jacob Gratten, Naomi R. Wray, Sang Hong Lee, Schizophrenia Working Group of the Psychiatric Genomics Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b121f8fd81f84b068af22ae55cb96139
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spelling	oai:doaj.org-article:b121f8fd81f84b068af22ae55cb961392021-12-02T11:40:46ZAge at first birth in women is genetically associated with increased risk of schizophrenia10.1038/s41598-018-28160-z2045-2322https://doaj.org/article/b121f8fd81f84b068af22ae55cb961392018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-28160-zhttps://doaj.org/toc/2045-2322Abstract Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is −0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.Guiyan NiJacob GrattenNaomi R. WraySang Hong LeeSchizophrenia Working Group of the Psychiatric Genomics ConsortiumNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guiyan Ni Jacob Gratten Naomi R. Wray Sang Hong Lee Schizophrenia Working Group of the Psychiatric Genomics Consortium Age at first birth in women is genetically associated with increased risk of schizophrenia
description	Abstract Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is −0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.
format	article
author	Guiyan Ni Jacob Gratten Naomi R. Wray Sang Hong Lee Schizophrenia Working Group of the Psychiatric Genomics Consortium
author_facet	Guiyan Ni Jacob Gratten Naomi R. Wray Sang Hong Lee Schizophrenia Working Group of the Psychiatric Genomics Consortium
author_sort	Guiyan Ni
title	Age at first birth in women is genetically associated with increased risk of schizophrenia
title_short	Age at first birth in women is genetically associated with increased risk of schizophrenia
title_full	Age at first birth in women is genetically associated with increased risk of schizophrenia
title_fullStr	Age at first birth in women is genetically associated with increased risk of schizophrenia
title_full_unstemmed	Age at first birth in women is genetically associated with increased risk of schizophrenia
title_sort	age at first birth in women is genetically associated with increased risk of schizophrenia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b121f8fd81f84b068af22ae55cb96139
work_keys_str_mv	AT guiyanni ageatfirstbirthinwomenisgeneticallyassociatedwithincreasedriskofschizophrenia AT jacobgratten ageatfirstbirthinwomenisgeneticallyassociatedwithincreasedriskofschizophrenia AT naomirwray ageatfirstbirthinwomenisgeneticallyassociatedwithincreasedriskofschizophrenia AT sanghonglee ageatfirstbirthinwomenisgeneticallyassociatedwithincreasedriskofschizophrenia AT schizophreniaworkinggroupofthepsychiatricgenomicsconsortium ageatfirstbirthinwomenisgeneticallyassociatedwithincreasedriskofschizophrenia
_version_	1718395539876216832

Age at first birth in women is genetically associated with increased risk of schizophrenia

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