Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation

Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation

Holes in endothelial barriers, called transendothelial cell macroapertures (TEMs), are predicted to be limited by line tension of unknown origin. Here the authors identify an actomyosin cable encircling TEMs and establish a role for ezrin in stabilising F-actin bundles, allowing their crosslinking b...

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Autores principales: Caroline Stefani, David Gonzalez-Rodriguez, Yosuke Senju, Anne Doye, Nadia Efimova, Sébastien Janel, Justine Lipuma, Meng Chen Tsai, Daniel Hamaoui, Madhavi P. Maddugoda, Olivier Cochet-Escartin, Coline Prévost, Frank Lafont, Tatyana Svitkina, Pekka Lappalainen, Patricia Bassereau, Emmanuel Lemichez
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b124a0879bef45a0aa24bea545ed4ff2
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spelling oai:doaj.org-article:b124a0879bef45a0aa24bea545ed4ff22021-12-02T15:38:46ZEzrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation10.1038/ncomms158392041-1723https://doaj.org/article/b124a0879bef45a0aa24bea545ed4ff22017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15839https://doaj.org/toc/2041-1723Holes in endothelial barriers, called transendothelial cell macroapertures (TEMs), are predicted to be limited by line tension of unknown origin. Here the authors identify an actomyosin cable encircling TEMs and establish a role for ezrin in stabilising F-actin bundles, allowing their crosslinking by non-muscle myosin IIa.Caroline StefaniDavid Gonzalez-RodriguezYosuke SenjuAnne DoyeNadia EfimovaSébastien JanelJustine LipumaMeng Chen TsaiDaniel HamaouiMadhavi P. MaddugodaOlivier Cochet-EscartinColine PrévostFrank LafontTatyana SvitkinaPekka LappalainenPatricia BassereauEmmanuel LemichezNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Caroline Stefani
David Gonzalez-Rodriguez
Yosuke Senju
Anne Doye
Nadia Efimova
Sébastien Janel
Justine Lipuma
Meng Chen Tsai
Daniel Hamaoui
Madhavi P. Maddugoda
Olivier Cochet-Escartin
Coline Prévost
Frank Lafont
Tatyana Svitkina
Pekka Lappalainen
Patricia Bassereau
Emmanuel Lemichez
Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation
description Holes in endothelial barriers, called transendothelial cell macroapertures (TEMs), are predicted to be limited by line tension of unknown origin. Here the authors identify an actomyosin cable encircling TEMs and establish a role for ezrin in stabilising F-actin bundles, allowing their crosslinking by non-muscle myosin IIa.
format article
author Caroline Stefani
David Gonzalez-Rodriguez
Yosuke Senju
Anne Doye
Nadia Efimova
Sébastien Janel
Justine Lipuma
Meng Chen Tsai
Daniel Hamaoui
Madhavi P. Maddugoda
Olivier Cochet-Escartin
Coline Prévost
Frank Lafont
Tatyana Svitkina
Pekka Lappalainen
Patricia Bassereau
Emmanuel Lemichez
author_facet Caroline Stefani
David Gonzalez-Rodriguez
Yosuke Senju
Anne Doye
Nadia Efimova
Sébastien Janel
Justine Lipuma
Meng Chen Tsai
Daniel Hamaoui
Madhavi P. Maddugoda
Olivier Cochet-Escartin
Coline Prévost
Frank Lafont
Tatyana Svitkina
Pekka Lappalainen
Patricia Bassereau
Emmanuel Lemichez
author_sort Caroline Stefani
title Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation
title_short Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation
title_full Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation
title_fullStr Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation
title_full_unstemmed Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation
title_sort ezrin enhances line tension along transcellular tunnel edges via nmiia driven actomyosin cable formation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b124a0879bef45a0aa24bea545ed4ff2
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