Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI

HHARI is a RING-in-between-RING (RBR) ubiquitin (Ub) E3 ligase. Here the authors present the crystal structure of HHARI with the UbcH7 ~ Ub thioester intermediate mimetic, which reveals that HHARI binds this E2 ~ Ub in an open conformation and explains the specificity of this cognate RBR E3/E2 pair....

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Autores principales:	Lingmin Yuan, Zongyang Lv, James H. Atkison, Shaun K. Olsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b125b1c0b12a41e5826dffb3c573ad1e
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spelling	oai:doaj.org-article:b125b1c0b12a41e5826dffb3c573ad1e2021-12-02T14:16:40ZStructural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI10.1038/s41467-017-00272-62041-1723https://doaj.org/article/b125b1c0b12a41e5826dffb3c573ad1e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00272-6https://doaj.org/toc/2041-1723HHARI is a RING-in-between-RING (RBR) ubiquitin (Ub) E3 ligase. Here the authors present the crystal structure of HHARI with the UbcH7 ~ Ub thioester intermediate mimetic, which reveals that HHARI binds this E2 ~ Ub in an open conformation and explains the specificity of this cognate RBR E3/E2 pair.Lingmin YuanZongyang LvJames H. AtkisonShaun K. OlsenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lingmin Yuan Zongyang Lv James H. Atkison Shaun K. Olsen Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI
description	HHARI is a RING-in-between-RING (RBR) ubiquitin (Ub) E3 ligase. Here the authors present the crystal structure of HHARI with the UbcH7 ~ Ub thioester intermediate mimetic, which reveals that HHARI binds this E2 ~ Ub in an open conformation and explains the specificity of this cognate RBR E3/E2 pair.
format	article
author	Lingmin Yuan Zongyang Lv James H. Atkison Shaun K. Olsen
author_facet	Lingmin Yuan Zongyang Lv James H. Atkison Shaun K. Olsen
author_sort	Lingmin Yuan
title	Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI
title_short	Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI
title_full	Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI
title_fullStr	Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI
title_full_unstemmed	Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI
title_sort	structural insights into the mechanism and e2 specificity of the rbr e3 ubiquitin ligase hhari
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b125b1c0b12a41e5826dffb3c573ad1e
work_keys_str_mv	AT lingminyuan structuralinsightsintothemechanismande2specificityoftherbre3ubiquitinligasehhari AT zongyanglv structuralinsightsintothemechanismande2specificityoftherbre3ubiquitinligasehhari AT jameshatkison structuralinsightsintothemechanismande2specificityoftherbre3ubiquitinligasehhari AT shaunkolsen structuralinsightsintothemechanismande2specificityoftherbre3ubiquitinligasehhari
_version_	1718391686770458624

Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI

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