EFFECT OF MICROENCAPSULATED NAPROXEN INTO POLY(LACTIDE-COGLYCOLIDE)MICROSPHERES ON CARRAGEENIN PAW EDEMA IN RATS

Microparticles are pharmaceutical dosage forms widely used because they may improve the therapeutic application of new and conventional drugs. In this work we make biodegradable microparticles with poly (lactic-co-glicolic) acid as polymer loaded with naproxen. The best microencapsulation conditions...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Diana M. ARAGÓN N., Nadezdha E. VERGEL B., Luis F. OSPINA G., Fleming Departamento de Farmacia. Universidad Na MARTÍNEZ R., Jaiver E. ROSAS P.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2010
Materias:	microencapsulation naproxen inflammation. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/b1295fd385c64cdc8ab11a0ceecdfbcc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b1295fd385c64cdc8ab11a0ceecdfbcc
record_format	dspace
spelling	oai:doaj.org-article:b1295fd385c64cdc8ab11a0ceecdfbcc2021-11-19T04:14:39ZEFFECT OF MICROENCAPSULATED NAPROXEN INTO POLY(LACTIDE-COGLYCOLIDE)MICROSPHERES ON CARRAGEENIN PAW EDEMA IN RATS0121-40042145-2660https://doaj.org/article/b1295fd385c64cdc8ab11a0ceecdfbcc2010-03-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/4976https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Microparticles are pharmaceutical dosage forms widely used because they may improve the therapeutic application of new and conventional drugs. In this work we make biodegradable microparticles with poly (lactic-co-glicolic) acid as polymer loaded with naproxen. The best microencapsulation conditions are experimentally determinate. We have found that the drug:polymer ratio, the isopropanol amount, the aqueous phase volume, the stir speed and the time of stir affect the microparticles characteristics. In the carragenin paw edema model, we have found that the microencapsulated naproxen at 5 mg/Kg and 10 mg/Kg showed greater effect than free naproxen at 10 mg/Kg.Diana M. ARAGÓN N.Nadezdha E. VERGEL B.Luis F. OSPINA G.Fleming Departamento de Farmacia. Universidad Na MARTÍNEZ R.Jaiver E. ROSAS P.Universidad de Antioquiaarticlemicroencapsulationnaproxeninflammation.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 17, Iss 1 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	microencapsulation naproxen inflammation. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	microencapsulation naproxen inflammation. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Diana M. ARAGÓN N. Nadezdha E. VERGEL B. Luis F. OSPINA G. Fleming Departamento de Farmacia. Universidad Na MARTÍNEZ R. Jaiver E. ROSAS P. EFFECT OF MICROENCAPSULATED NAPROXEN INTO POLY(LACTIDE-COGLYCOLIDE)MICROSPHERES ON CARRAGEENIN PAW EDEMA IN RATS
description	Microparticles are pharmaceutical dosage forms widely used because they may improve the therapeutic application of new and conventional drugs. In this work we make biodegradable microparticles with poly (lactic-co-glicolic) acid as polymer loaded with naproxen. The best microencapsulation conditions are experimentally determinate. We have found that the drug:polymer ratio, the isopropanol amount, the aqueous phase volume, the stir speed and the time of stir affect the microparticles characteristics. In the carragenin paw edema model, we have found that the microencapsulated naproxen at 5 mg/Kg and 10 mg/Kg showed greater effect than free naproxen at 10 mg/Kg.
format	article
author	Diana M. ARAGÓN N. Nadezdha E. VERGEL B. Luis F. OSPINA G. Fleming Departamento de Farmacia. Universidad Na MARTÍNEZ R. Jaiver E. ROSAS P.
author_facet	Diana M. ARAGÓN N. Nadezdha E. VERGEL B. Luis F. OSPINA G. Fleming Departamento de Farmacia. Universidad Na MARTÍNEZ R. Jaiver E. ROSAS P.
author_sort	Diana M. ARAGÓN N.
title	EFFECT OF MICROENCAPSULATED NAPROXEN INTO POLY(LACTIDE-COGLYCOLIDE)MICROSPHERES ON CARRAGEENIN PAW EDEMA IN RATS
title_short	EFFECT OF MICROENCAPSULATED NAPROXEN INTO POLY(LACTIDE-COGLYCOLIDE)MICROSPHERES ON CARRAGEENIN PAW EDEMA IN RATS
title_full	EFFECT OF MICROENCAPSULATED NAPROXEN INTO POLY(LACTIDE-COGLYCOLIDE)MICROSPHERES ON CARRAGEENIN PAW EDEMA IN RATS
title_fullStr	EFFECT OF MICROENCAPSULATED NAPROXEN INTO POLY(LACTIDE-COGLYCOLIDE)MICROSPHERES ON CARRAGEENIN PAW EDEMA IN RATS
title_full_unstemmed	EFFECT OF MICROENCAPSULATED NAPROXEN INTO POLY(LACTIDE-COGLYCOLIDE)MICROSPHERES ON CARRAGEENIN PAW EDEMA IN RATS
title_sort	effect of microencapsulated naproxen into poly(lactide-coglycolide)microspheres on carrageenin paw edema in rats
publisher	Universidad de Antioquia
publishDate	2010
url	https://doaj.org/article/b1295fd385c64cdc8ab11a0ceecdfbcc
work_keys_str_mv	AT dianamaragonn effectofmicroencapsulatednaproxenintopolylactidecoglycolidemicrospheresoncarrageeninpawedemainrats AT nadezdhaevergelb effectofmicroencapsulatednaproxenintopolylactidecoglycolidemicrospheresoncarrageeninpawedemainrats AT luisfospinag effectofmicroencapsulatednaproxenintopolylactidecoglycolidemicrospheresoncarrageeninpawedemainrats AT flemingdepartamentodefarmaciauniversidadnamartinezr effectofmicroencapsulatednaproxenintopolylactidecoglycolidemicrospheresoncarrageeninpawedemainrats AT jaivererosasp effectofmicroencapsulatednaproxenintopolylactidecoglycolidemicrospheresoncarrageeninpawedemainrats
_version_	1718420465543806976

EFFECT OF MICROENCAPSULATED NAPROXEN INTO POLY(LACTIDE-COGLYCOLIDE)MICROSPHERES ON CARRAGEENIN PAW EDEMA IN RATS

Ejemplares similares