IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

Systemic lupus erythematosus (SLE) is associated with altered B cell responses but the underlying aetiology is still unclear. Here the authors show that a CD11chiT-bet+ B cell subset with a unique phenotype and transcriptome is increased in patients with SLE, can be expanded by IL-21, and may contri...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shu Wang, Jingya Wang, Varsha Kumar, Jodi L. Karnell, Brian Naiman, Phillip S. Gross, Saifur Rahman, Kamelia Zerrouki, Richard Hanna, Christopher Morehouse, Nicholas Holoweckyj, Hao Liu, Autoimmunity Molecular Medicine Team, Zerai Manna, Raphaela Goldbach-Mansky, Sarfaraz Hasni, Richard Siegel, Miguel Sanjuan, Katie Streicher, Michael P. Cancro, Roland Kolbeck, Rachel Ettinger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b12a066bb82147b99f7c7c8fcb7739ef
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b12a066bb82147b99f7c7c8fcb7739ef
record_format	dspace
spelling	oai:doaj.org-article:b12a066bb82147b99f7c7c8fcb7739ef2021-12-02T15:34:48ZIL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE10.1038/s41467-018-03750-72041-1723https://doaj.org/article/b12a066bb82147b99f7c7c8fcb7739ef2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03750-7https://doaj.org/toc/2041-1723Systemic lupus erythematosus (SLE) is associated with altered B cell responses but the underlying aetiology is still unclear. Here the authors show that a CD11chiT-bet+ B cell subset with a unique phenotype and transcriptome is increased in patients with SLE, can be expanded by IL-21, and may contribute to autoimmune responses in SLE.Shu WangJingya WangVarsha KumarJodi L. KarnellBrian NaimanPhillip S. GrossSaifur RahmanKamelia ZerroukiRichard HannaChristopher MorehouseNicholas HoloweckyjHao LiuAutoimmunity Molecular Medicine TeamZerai MannaRaphaela Goldbach-ManskySarfaraz HasniRichard SiegelMiguel SanjuanKatie StreicherMichael P. CancroRoland KolbeckRachel EttingerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shu Wang Jingya Wang Varsha Kumar Jodi L. Karnell Brian Naiman Phillip S. Gross Saifur Rahman Kamelia Zerrouki Richard Hanna Christopher Morehouse Nicholas Holoweckyj Hao Liu Autoimmunity Molecular Medicine Team Zerai Manna Raphaela Goldbach-Mansky Sarfaraz Hasni Richard Siegel Miguel Sanjuan Katie Streicher Michael P. Cancro Roland Kolbeck Rachel Ettinger IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE
description	Systemic lupus erythematosus (SLE) is associated with altered B cell responses but the underlying aetiology is still unclear. Here the authors show that a CD11chiT-bet+ B cell subset with a unique phenotype and transcriptome is increased in patients with SLE, can be expanded by IL-21, and may contribute to autoimmune responses in SLE.
format	article
author	Shu Wang Jingya Wang Varsha Kumar Jodi L. Karnell Brian Naiman Phillip S. Gross Saifur Rahman Kamelia Zerrouki Richard Hanna Christopher Morehouse Nicholas Holoweckyj Hao Liu Autoimmunity Molecular Medicine Team Zerai Manna Raphaela Goldbach-Mansky Sarfaraz Hasni Richard Siegel Miguel Sanjuan Katie Streicher Michael P. Cancro Roland Kolbeck Rachel Ettinger
author_facet	Shu Wang Jingya Wang Varsha Kumar Jodi L. Karnell Brian Naiman Phillip S. Gross Saifur Rahman Kamelia Zerrouki Richard Hanna Christopher Morehouse Nicholas Holoweckyj Hao Liu Autoimmunity Molecular Medicine Team Zerai Manna Raphaela Goldbach-Mansky Sarfaraz Hasni Richard Siegel Miguel Sanjuan Katie Streicher Michael P. Cancro Roland Kolbeck Rachel Ettinger
author_sort	Shu Wang
title	IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE
title_short	IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE
title_full	IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE
title_fullStr	IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE
title_full_unstemmed	IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE
title_sort	il-21 drives expansion and plasma cell differentiation of autoreactive cd11chit-bet+ b cells in sle
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b12a066bb82147b99f7c7c8fcb7739ef
work_keys_str_mv	AT shuwang il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT jingyawang il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT varshakumar il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT jodilkarnell il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT briannaiman il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT phillipsgross il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT saifurrahman il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT kameliazerrouki il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT richardhanna il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT christophermorehouse il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT nicholasholoweckyj il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT haoliu il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT autoimmunitymolecularmedicineteam il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT zeraimanna il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT raphaelagoldbachmansky il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT sarfarazhasni il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT richardsiegel il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT miguelsanjuan il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT katiestreicher il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT michaelpcancro il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT rolandkolbeck il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle AT rachelettinger il21drivesexpansionandplasmacelldifferentiationofautoreactivecd11chitbetbcellsinsle
_version_	1718386738737446912

IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

Ejemplares similares