Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy

<i>Background and Objectives</i>: The aim of this study was to evaluate longitudinal changes using both upper limb muscle Magnetic Resonance Imaging (MRI) at shoulder, arm and forearm levels and Performance of upper limb (PUL) in ambulant and non-ambulant Duchenne Muscular Dystrophy (DMD...

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Autores principales:	Claudia Brogna, Lara Cristiano, Tommaso Verdolotti, Giulia Norcia, Luana Ficociello, Roberta Ruiz, Giorgia Coratti, Lavinia Fanelli, Nicola Forcina, Giorgia Petracca, Fabrizia Chieppa, Tommaso Tartaglione, Cesare Colosimo, Marika Pane, Eugenio Mercuri
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	muscle MRI PUL DMD Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b12a751ded744081a88f70dc9373aa83
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spelling	oai:doaj.org-article:b12a751ded744081a88f70dc9373aa832021-11-25T18:19:05ZLongitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy10.3390/medicina571112671648-91441010-660Xhttps://doaj.org/article/b12a751ded744081a88f70dc9373aa832021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1267https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144<i>Background and Objectives</i>: The aim of this study was to evaluate longitudinal changes using both upper limb muscle Magnetic Resonance Imaging (MRI) at shoulder, arm and forearm levels and Performance of upper limb (PUL) in ambulant and non-ambulant Duchenne Muscular Dystrophy (DMD) patients. We also wished to define whether baseline muscle MRI could help to predict functional changes after one year. <i>Materials and Methods</i>: Twenty-seven patients had both baseline and 12month muscle MRI and PUL assessments one year later. <i>Results</i>: Ten were ambulant (age range 5–16 years), and 17 non ambulant (age range 10–30 years). Increased abnormalities equal or more than 1.5 point on muscle MRI at follow up were found on all domains: at shoulder level 12/27 patients (44%), at arm level 4/27 (15%) and at forearm level 6/27 (22%). Lower follow up PUL score were found in 8/27 patients (30%) at shoulder level, in 9/27 patients (33%) at mid-level whereas no functional changes were found at distal level. There was no constant association between baseline MRI scores and follow up PUL scores at arm and forearm levels but at shoulder level patients with moderate impairment on the baseline MRI scores between 16 and 34 had the highest risk of decreased function on PUL over a year. <i>Conclusions</i>: Our results confirmed that the integrated use of functional scales and imaging can help to monitor functional and MRI changes over time.Claudia BrognaLara CristianoTommaso VerdolottiGiulia NorciaLuana FicocielloRoberta RuizGiorgia CorattiLavinia FanelliNicola ForcinaGiorgia PetraccaFabrizia ChieppaTommaso TartaglioneCesare ColosimoMarika PaneEugenio MercuriMDPI AGarticlemuscle MRIPULDMDMedicine (General)R5-920ENMedicina, Vol 57, Iss 1267, p 1267 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	muscle MRI PUL DMD Medicine (General) R5-920
spellingShingle	muscle MRI PUL DMD Medicine (General) R5-920 Claudia Brogna Lara Cristiano Tommaso Verdolotti Giulia Norcia Luana Ficociello Roberta Ruiz Giorgia Coratti Lavinia Fanelli Nicola Forcina Giorgia Petracca Fabrizia Chieppa Tommaso Tartaglione Cesare Colosimo Marika Pane Eugenio Mercuri Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy
description	<i>Background and Objectives</i>: The aim of this study was to evaluate longitudinal changes using both upper limb muscle Magnetic Resonance Imaging (MRI) at shoulder, arm and forearm levels and Performance of upper limb (PUL) in ambulant and non-ambulant Duchenne Muscular Dystrophy (DMD) patients. We also wished to define whether baseline muscle MRI could help to predict functional changes after one year. <i>Materials and Methods</i>: Twenty-seven patients had both baseline and 12month muscle MRI and PUL assessments one year later. <i>Results</i>: Ten were ambulant (age range 5–16 years), and 17 non ambulant (age range 10–30 years). Increased abnormalities equal or more than 1.5 point on muscle MRI at follow up were found on all domains: at shoulder level 12/27 patients (44%), at arm level 4/27 (15%) and at forearm level 6/27 (22%). Lower follow up PUL score were found in 8/27 patients (30%) at shoulder level, in 9/27 patients (33%) at mid-level whereas no functional changes were found at distal level. There was no constant association between baseline MRI scores and follow up PUL scores at arm and forearm levels but at shoulder level patients with moderate impairment on the baseline MRI scores between 16 and 34 had the highest risk of decreased function on PUL over a year. <i>Conclusions</i>: Our results confirmed that the integrated use of functional scales and imaging can help to monitor functional and MRI changes over time.
format	article
author	Claudia Brogna Lara Cristiano Tommaso Verdolotti Giulia Norcia Luana Ficociello Roberta Ruiz Giorgia Coratti Lavinia Fanelli Nicola Forcina Giorgia Petracca Fabrizia Chieppa Tommaso Tartaglione Cesare Colosimo Marika Pane Eugenio Mercuri
author_facet	Claudia Brogna Lara Cristiano Tommaso Verdolotti Giulia Norcia Luana Ficociello Roberta Ruiz Giorgia Coratti Lavinia Fanelli Nicola Forcina Giorgia Petracca Fabrizia Chieppa Tommaso Tartaglione Cesare Colosimo Marika Pane Eugenio Mercuri
author_sort	Claudia Brogna
title	Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy
title_short	Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy
title_full	Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy
title_fullStr	Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy
title_full_unstemmed	Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy
title_sort	longitudinal motor functional outcomes and magnetic resonance imaging patterns of muscle involvement in upper limbs in duchenne muscular dystrophy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b12a751ded744081a88f70dc9373aa83
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Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy

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