Bladder cancer in the elderly patient: challenges and solutions

Elizabeth A Guancial,1 Breton Roussel,2 Derek P Bergsma,3 Kevin C Bylund,3 Deepak Sahasrabudhe,1 Edward Messing,4 Supriya G Mohile,1 Chunkit Fung1 1Division of Hematology/Oncology, Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical Center School of Medicine and Dentist...

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Autores principales:	Guancial EA, Roussel B, Bergsma DP, Bylund KC, Sahasrabudhe D, Messing E, Mohile SG, Fung C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	bladder cancer elderly quality of life surgery radiation therapy chemotherapy Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/b12fa2d1a8704260bbcb991c7e719487
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spelling	oai:doaj.org-article:b12fa2d1a8704260bbcb991c7e7194872021-12-02T07:19:21ZBladder cancer in the elderly patient: challenges and solutions1178-1998https://doaj.org/article/b12fa2d1a8704260bbcb991c7e7194872015-06-01T00:00:00Zhttps://www.dovepress.com/bladder-cancer-in-the-elderly-patient-challenges-and-solutions-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Elizabeth A Guancial,1 Breton Roussel,2 Derek P Bergsma,3 Kevin C Bylund,3 Deepak Sahasrabudhe,1 Edward Messing,4 Supriya G Mohile,1 Chunkit Fung1 1Division of Hematology/Oncology, Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical Center School of Medicine and Dentistry, Rochester, NY, 2Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, 3Department of Radiation Oncology, Wilmot Cancer Institute, University of Rochester, Rochester, NY, 4Department of Urology, University of Rochester, Rochester, NY, USA Abstract: Bladder cancer (BC) is an age-associated malignancy with increased prevalence in the elderly population. Elderly patients are a vulnerable population at increased risk for treatment-related toxicity secondary to medical comorbidities and geriatric syndromes. As a result, this population has been historically undertreated and suffers worse disease-specific outcomes than younger patients with BC. Recognition of this disparity has led to efforts to individualize treatment decisions based on functional status rather than chronologic age in an effort to optimize the use of curative therapies for the fit elderly and modify treatments to reduce the risk of toxicity and disease-related morbidity in vulnerable or frail patients. The comprehensive geriatric assessment is a decision framework that helps to balance underlying health considerations and risks of therapy with aggressiveness of the cancer. Development of systemic therapies with increased efficacy against BC and reduced toxicity are eagerly awaited, as are techniques and interventions to reduce the morbidity from surgery and radiation for patients with BC. Keywords: bladder cancer, elderly, quality of life, surgery, radiation therapy, chemotherapyGuancial EARoussel BBergsma DPBylund KCSahasrabudhe DMessing EMohile SGFung CDove Medical Pressarticlebladder cancerelderlyquality of lifesurgeryradiation therapychemotherapyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 10, Pp 939-949 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	bladder cancer elderly quality of life surgery radiation therapy chemotherapy Geriatrics RC952-954.6
spellingShingle	bladder cancer elderly quality of life surgery radiation therapy chemotherapy Geriatrics RC952-954.6 Guancial EA Roussel B Bergsma DP Bylund KC Sahasrabudhe D Messing E Mohile SG Fung C Bladder cancer in the elderly patient: challenges and solutions
description	Elizabeth A Guancial,1 Breton Roussel,2 Derek P Bergsma,3 Kevin C Bylund,3 Deepak Sahasrabudhe,1 Edward Messing,4 Supriya G Mohile,1 Chunkit Fung1 1Division of Hematology/Oncology, Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical Center School of Medicine and Dentistry, Rochester, NY, 2Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, 3Department of Radiation Oncology, Wilmot Cancer Institute, University of Rochester, Rochester, NY, 4Department of Urology, University of Rochester, Rochester, NY, USA Abstract: Bladder cancer (BC) is an age-associated malignancy with increased prevalence in the elderly population. Elderly patients are a vulnerable population at increased risk for treatment-related toxicity secondary to medical comorbidities and geriatric syndromes. As a result, this population has been historically undertreated and suffers worse disease-specific outcomes than younger patients with BC. Recognition of this disparity has led to efforts to individualize treatment decisions based on functional status rather than chronologic age in an effort to optimize the use of curative therapies for the fit elderly and modify treatments to reduce the risk of toxicity and disease-related morbidity in vulnerable or frail patients. The comprehensive geriatric assessment is a decision framework that helps to balance underlying health considerations and risks of therapy with aggressiveness of the cancer. Development of systemic therapies with increased efficacy against BC and reduced toxicity are eagerly awaited, as are techniques and interventions to reduce the morbidity from surgery and radiation for patients with BC. Keywords: bladder cancer, elderly, quality of life, surgery, radiation therapy, chemotherapy
format	article
author	Guancial EA Roussel B Bergsma DP Bylund KC Sahasrabudhe D Messing E Mohile SG Fung C
author_facet	Guancial EA Roussel B Bergsma DP Bylund KC Sahasrabudhe D Messing E Mohile SG Fung C
author_sort	Guancial EA
title	Bladder cancer in the elderly patient: challenges and solutions
title_short	Bladder cancer in the elderly patient: challenges and solutions
title_full	Bladder cancer in the elderly patient: challenges and solutions
title_fullStr	Bladder cancer in the elderly patient: challenges and solutions
title_full_unstemmed	Bladder cancer in the elderly patient: challenges and solutions
title_sort	bladder cancer in the elderly patient: challenges and solutions
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/b12fa2d1a8704260bbcb991c7e719487
work_keys_str_mv	AT guancialea bladdercancerintheelderlypatientchallengesandsolutions AT rousselb bladdercancerintheelderlypatientchallengesandsolutions AT bergsmadp bladdercancerintheelderlypatientchallengesandsolutions AT bylundkc bladdercancerintheelderlypatientchallengesandsolutions AT sahasrabudhed bladdercancerintheelderlypatientchallengesandsolutions AT messinge bladdercancerintheelderlypatientchallengesandsolutions AT mohilesg bladdercancerintheelderlypatientchallengesandsolutions AT fungc bladdercancerintheelderlypatientchallengesandsolutions
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Bladder cancer in the elderly patient: challenges and solutions

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