Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac

Thangirala Sudha,1 Dhruba J Bharali,1 Murat Yalcin,1,2 Noureldien HE Darwish,1,3 Melis Debreli Coskun,1,4 Kelly A Keating,1 Hung-Yun Lin,5,6 Paul J Davis,1,7 Shaker A Mousa1 1The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA; 2Department of P...

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Autores principales:	Sudha T, Bharali DJ, Yalcin M, Darwish NHE, Debreli Coskun M, Keating KA, Lin HY, Davis PJ, Mousa SA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	doxorubicin integrin nanoparticle Nanotetrac NDAT paclitaxel tetraiodothyroacetic acid xenografts Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b1306e1c4c464480a5a9e3d71c8efe48
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spelling	oai:doaj.org-article:b1306e1c4c464480a5a9e3d71c8efe482021-12-02T04:21:03ZTargeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac1178-2013https://doaj.org/article/b1306e1c4c464480a5a9e3d71c8efe482017-02-01T00:00:00Zhttps://www.dovepress.com/targeted-delivery-of-paclitaxel-and-doxorubicin-to-cancer-xenografts-v-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Thangirala Sudha,1 Dhruba J Bharali,1 Murat Yalcin,1,2 Noureldien HE Darwish,1,3 Melis Debreli Coskun,1,4 Kelly A Keating,1 Hung-Yun Lin,5,6 Paul J Davis,1,7 Shaker A Mousa1 1The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA; 2Department of Physiology, Veterinary Medicine Faculty, Uludag University, Gorukle, Bursa, Turkey; 3Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 4Department of Biology, Faculty of Arts and Sciences, Uludag University, Gorukle, Bursa, Turkey; 5PhD Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, 6Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan; 7Department of Medicine, Albany Medical College, Albany, NY, USA Abstract: The tetraiodothyroacetic acid (tetrac) component of nano-diamino-tetrac (NDAT) is chemically bonded via a linker to a poly(lactic-co-glycolic acid) nanoparticle that can encapsulate anticancer drugs. Tetrac targets the plasma membrane of cancer cells at a receptor on the extracellular domain of integrin αvβ3. In this study, we evaluate the efficiency of NDAT delivery of paclitaxel and doxorubicin to, respectively, pancreatic and breast cancer orthotopic nude mouse xenografts. Intra-tumoral drug concentrations were 5-fold (paclitaxel; P<0.001) and 2.3-fold (doxorubicin; P<0.01) higher than with conventional systemic drug administration. Tumor volume reductions reflected enhanced xenograft drug uptake. Cell viability was estimated by bioluminescent signaling in pancreatic tumors and confirmed an increased paclitaxel effect with drug delivery by NDAT. NDAT delivery of chemotherapy increases drug delivery to cancers and increases drug efficacy. Keywords: doxorubicin, integrin, nanoparticle, Nanotetrac, NDAT, paclitaxel, tetraiodothyroacetic acid, xenograftsSudha TBharali DJYalcin MDarwish NHEDebreli Coskun MKeating KALin HYDavis PJMousa SADove Medical PressarticledoxorubicinintegrinnanoparticleNanotetracNDATpaclitaxeltetraiodothyroacetic acidxenograftsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 1305-1315 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	doxorubicin integrin nanoparticle Nanotetrac NDAT paclitaxel tetraiodothyroacetic acid xenografts Medicine (General) R5-920
spellingShingle	doxorubicin integrin nanoparticle Nanotetrac NDAT paclitaxel tetraiodothyroacetic acid xenografts Medicine (General) R5-920 Sudha T Bharali DJ Yalcin M Darwish NHE Debreli Coskun M Keating KA Lin HY Davis PJ Mousa SA Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac
description	Thangirala Sudha,1 Dhruba J Bharali,1 Murat Yalcin,1,2 Noureldien HE Darwish,1,3 Melis Debreli Coskun,1,4 Kelly A Keating,1 Hung-Yun Lin,5,6 Paul J Davis,1,7 Shaker A Mousa1 1The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA; 2Department of Physiology, Veterinary Medicine Faculty, Uludag University, Gorukle, Bursa, Turkey; 3Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 4Department of Biology, Faculty of Arts and Sciences, Uludag University, Gorukle, Bursa, Turkey; 5PhD Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, 6Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan; 7Department of Medicine, Albany Medical College, Albany, NY, USA Abstract: The tetraiodothyroacetic acid (tetrac) component of nano-diamino-tetrac (NDAT) is chemically bonded via a linker to a poly(lactic-co-glycolic acid) nanoparticle that can encapsulate anticancer drugs. Tetrac targets the plasma membrane of cancer cells at a receptor on the extracellular domain of integrin αvβ3. In this study, we evaluate the efficiency of NDAT delivery of paclitaxel and doxorubicin to, respectively, pancreatic and breast cancer orthotopic nude mouse xenografts. Intra-tumoral drug concentrations were 5-fold (paclitaxel; P<0.001) and 2.3-fold (doxorubicin; P<0.01) higher than with conventional systemic drug administration. Tumor volume reductions reflected enhanced xenograft drug uptake. Cell viability was estimated by bioluminescent signaling in pancreatic tumors and confirmed an increased paclitaxel effect with drug delivery by NDAT. NDAT delivery of chemotherapy increases drug delivery to cancers and increases drug efficacy. Keywords: doxorubicin, integrin, nanoparticle, Nanotetrac, NDAT, paclitaxel, tetraiodothyroacetic acid, xenografts
format	article
author	Sudha T Bharali DJ Yalcin M Darwish NHE Debreli Coskun M Keating KA Lin HY Davis PJ Mousa SA
author_facet	Sudha T Bharali DJ Yalcin M Darwish NHE Debreli Coskun M Keating KA Lin HY Davis PJ Mousa SA
author_sort	Sudha T
title	Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac
title_short	Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac
title_full	Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac
title_fullStr	Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac
title_full_unstemmed	Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac
title_sort	targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/b1306e1c4c464480a5a9e3d71c8efe48
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Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac

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