Copy number alteration of neuropeptides and receptors in multiple cancers

Abstract Neuropeptides are peptide hormones used as chemical signals by the neuroendocrine system to communicate between cells. Recently, neuropeptides have been recognized for their ability to act as potent cellular growth factors on many cell types, including cancer cells. However, the molecular m...

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Autores principales:	Min Zhao, Tianfang Wang, Qi Liu, Scott Cummins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b131ab01776d4a62a2da6715e2c4ac7b
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spelling	oai:doaj.org-article:b131ab01776d4a62a2da6715e2c4ac7b2021-12-02T12:32:57ZCopy number alteration of neuropeptides and receptors in multiple cancers10.1038/s41598-017-04832-02045-2322https://doaj.org/article/b131ab01776d4a62a2da6715e2c4ac7b2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04832-0https://doaj.org/toc/2045-2322Abstract Neuropeptides are peptide hormones used as chemical signals by the neuroendocrine system to communicate between cells. Recently, neuropeptides have been recognized for their ability to act as potent cellular growth factors on many cell types, including cancer cells. However, the molecular mechanism for how this occurs is unknown. To clarify the relationship between neuropeptides and cancer, we manually curated a total of 127 human neuropeptide genes by integrating information from the literature, homologous sequences, and database searches. Using human ligand-receptor interaction data, we first identified an interactome of 226 interaction pairs between 93 neuropeptides and 133 G-protein coupled receptors. We further identified four neuropeptide-receptor functional modules with ten or more genes, all of which were highly mutated in multiple cancers. We have identified a number of neuropeptide signaling systems with both oncogenic and tumour-suppressing roles for cancer progression, such as the insulin-like growth factors. By focusing on the neuroendocrine prostate cancer mutational data, we found prevalent amplification of neuropeptide and receptors in about 72% of samples. In summary, we report the first observation of abundant copy number variations on neuropeptides and receptors, which will be valuable for the design of peptide-based cancer prognosis, diagnosis and treatment.Min ZhaoTianfang WangQi LiuScott CumminsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min Zhao Tianfang Wang Qi Liu Scott Cummins Copy number alteration of neuropeptides and receptors in multiple cancers
description	Abstract Neuropeptides are peptide hormones used as chemical signals by the neuroendocrine system to communicate between cells. Recently, neuropeptides have been recognized for their ability to act as potent cellular growth factors on many cell types, including cancer cells. However, the molecular mechanism for how this occurs is unknown. To clarify the relationship between neuropeptides and cancer, we manually curated a total of 127 human neuropeptide genes by integrating information from the literature, homologous sequences, and database searches. Using human ligand-receptor interaction data, we first identified an interactome of 226 interaction pairs between 93 neuropeptides and 133 G-protein coupled receptors. We further identified four neuropeptide-receptor functional modules with ten or more genes, all of which were highly mutated in multiple cancers. We have identified a number of neuropeptide signaling systems with both oncogenic and tumour-suppressing roles for cancer progression, such as the insulin-like growth factors. By focusing on the neuroendocrine prostate cancer mutational data, we found prevalent amplification of neuropeptide and receptors in about 72% of samples. In summary, we report the first observation of abundant copy number variations on neuropeptides and receptors, which will be valuable for the design of peptide-based cancer prognosis, diagnosis and treatment.
format	article
author	Min Zhao Tianfang Wang Qi Liu Scott Cummins
author_facet	Min Zhao Tianfang Wang Qi Liu Scott Cummins
author_sort	Min Zhao
title	Copy number alteration of neuropeptides and receptors in multiple cancers
title_short	Copy number alteration of neuropeptides and receptors in multiple cancers
title_full	Copy number alteration of neuropeptides and receptors in multiple cancers
title_fullStr	Copy number alteration of neuropeptides and receptors in multiple cancers
title_full_unstemmed	Copy number alteration of neuropeptides and receptors in multiple cancers
title_sort	copy number alteration of neuropeptides and receptors in multiple cancers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b131ab01776d4a62a2da6715e2c4ac7b
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_version_	1718393940670939136

Copy number alteration of neuropeptides and receptors in multiple cancers

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