The relationship between sex and symmetry in thyroid eye disease

Shaheen C Kavoussi,1 Joseph N Giacometti,2 J Javier Servat,1 Flora Levin11Department of Ophthalmology and Visual Science, Yale University, New Haven, CT, USA; 2Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USAPurpose: To examine the relationships betwee...

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Autores principales:	Kavoussi SC, Giacometti JN, Servat JJ, Levin F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b13742618922474a9320feed7b9685cc
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spelling	oai:doaj.org-article:b13742618922474a9320feed7b9685cc2021-12-02T03:24:39ZThe relationship between sex and symmetry in thyroid eye disease1177-5483https://doaj.org/article/b13742618922474a9320feed7b9685cc2014-07-01T00:00:00Zhttp://www.dovepress.com/the-relationship-between-sex-and-symmetry-in-thyroid-eye-disease-a17534https://doaj.org/toc/1177-5483 Shaheen C Kavoussi,1 Joseph N Giacometti,2 J Javier Servat,1 Flora Levin11Department of Ophthalmology and Visual Science, Yale University, New Haven, CT, USA; 2Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USAPurpose: To examine the relationships between sex and symmetry in the context of disease activity, severity, and thyroid status in thyroid eye disease.Methods: Retrospective chart review of 31 men and 31 women with untreated thyroid eye disease. Subjective complaints, smoking status, thyroid status, and objective findings pertinent to the clinical activity score (CAS) and “NO SPECS” classification were recorded. Overall disease asymmetry was defined as having simultaneous asymmetry of both more than one symptom and more than one external finding. Asymmetry was compared across sex and thyroid status. CAS and NO SPECS severity were compared across sex, symmetry, and thyroid status. Results: Asymmetric appearance was reported by 58% of men and 19% of women. Asymmetric proptosis (>2 mm difference) was seen in 45% of men and 23% of women (P=0.036). Overall asymmetry was seen in 55% of men and 19% of women (P=0.017). Thyroid status and sex had a combined effect on symmetry, as 15 of 16 hyperthyroid females (94%) demonstrated symmetric disease. Average NO SPECS severity was 3.5 (standard deviation [SD] 1.4) in men and 3.3 (SD 1.1) in women (P=0.51), and was 3.8 (SD 1.4) in asymmetric patients versus 3.2 (SD 1.3) in symmetric patients (P=0.08). The CAS was higher in asymmetric than symmetric patients (1.84 versus 0.97; P=0.012). Conclusion: Men demonstrated more asymmetric disease (proptosis and overall asymmetry) than women, while hyperthyroid females demonstrated more symmetry than euthyroid and hypothyroid males and females. NO SPECS severity score was unaffected by sex, thyroid status, or symmetry. Asymmetric patients demonstrated higher clinical activity scores.Keywords: Graves’ ophthalmopathy, thyroid status, clinical activity score, NO SPECSKavoussi SCGiacometti JNServat JJLevin FDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1295-1300 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Kavoussi SC Giacometti JN Servat JJ Levin F The relationship between sex and symmetry in thyroid eye disease
description	Shaheen C Kavoussi,1 Joseph N Giacometti,2 J Javier Servat,1 Flora Levin11Department of Ophthalmology and Visual Science, Yale University, New Haven, CT, USA; 2Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USAPurpose: To examine the relationships between sex and symmetry in the context of disease activity, severity, and thyroid status in thyroid eye disease.Methods: Retrospective chart review of 31 men and 31 women with untreated thyroid eye disease. Subjective complaints, smoking status, thyroid status, and objective findings pertinent to the clinical activity score (CAS) and “NO SPECS” classification were recorded. Overall disease asymmetry was defined as having simultaneous asymmetry of both more than one symptom and more than one external finding. Asymmetry was compared across sex and thyroid status. CAS and NO SPECS severity were compared across sex, symmetry, and thyroid status. Results: Asymmetric appearance was reported by 58% of men and 19% of women. Asymmetric proptosis (>2 mm difference) was seen in 45% of men and 23% of women (P=0.036). Overall asymmetry was seen in 55% of men and 19% of women (P=0.017). Thyroid status and sex had a combined effect on symmetry, as 15 of 16 hyperthyroid females (94%) demonstrated symmetric disease. Average NO SPECS severity was 3.5 (standard deviation [SD] 1.4) in men and 3.3 (SD 1.1) in women (P=0.51), and was 3.8 (SD 1.4) in asymmetric patients versus 3.2 (SD 1.3) in symmetric patients (P=0.08). The CAS was higher in asymmetric than symmetric patients (1.84 versus 0.97; P=0.012). Conclusion: Men demonstrated more asymmetric disease (proptosis and overall asymmetry) than women, while hyperthyroid females demonstrated more symmetry than euthyroid and hypothyroid males and females. NO SPECS severity score was unaffected by sex, thyroid status, or symmetry. Asymmetric patients demonstrated higher clinical activity scores.Keywords: Graves’ ophthalmopathy, thyroid status, clinical activity score, NO SPECS
format	article
author	Kavoussi SC Giacometti JN Servat JJ Levin F
author_facet	Kavoussi SC Giacometti JN Servat JJ Levin F
author_sort	Kavoussi SC
title	The relationship between sex and symmetry in thyroid eye disease
title_short	The relationship between sex and symmetry in thyroid eye disease
title_full	The relationship between sex and symmetry in thyroid eye disease
title_fullStr	The relationship between sex and symmetry in thyroid eye disease
title_full_unstemmed	The relationship between sex and symmetry in thyroid eye disease
title_sort	relationship between sex and symmetry in thyroid eye disease
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/b13742618922474a9320feed7b9685cc
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The relationship between sex and symmetry in thyroid eye disease

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