Association between statin use and Alzheimer’s disease with dose response relationship

Abstract This study aimed to determine the dose–response relationship between the levels of statin exposure and the incidence of Alzheimer’s disease (AD). We included 119,013 Korean adults (≥ 60 years old) using a database from the Korean National Health Insurance Service (2002–2013). Statin exposur...

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Autores principales:	Su-Min Jeong, Dong Wook Shin, Tae Gon Yoo, Mi Hee Cho, Wooyoung Jang, Jinkook Lee, SangYun Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b139a4a5764d42ceac5012d84c718bcc
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spelling	oai:doaj.org-article:b139a4a5764d42ceac5012d84c718bcc2021-12-02T16:23:42ZAssociation between statin use and Alzheimer’s disease with dose response relationship10.1038/s41598-021-94803-32045-2322https://doaj.org/article/b139a4a5764d42ceac5012d84c718bcc2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94803-3https://doaj.org/toc/2045-2322Abstract This study aimed to determine the dose–response relationship between the levels of statin exposure and the incidence of Alzheimer’s disease (AD). We included 119,013 Korean adults (≥ 60 years old) using a database from the Korean National Health Insurance Service (2002–2013). Statin exposure was treated as a time-varying variable. Incidence of AD was defined by the first claim code for AD with anti-Alzheimer drugs. AD occurred in 9467 cases during a median 7.2 years of follow-up. Overall, statin use was not associated with an increased risk of AD incidence [adjusted hazard ratio (aHR) = 1.04; 95% confidence interval (CI) = 0.99–1.10]. When examined by level of statin exposure, statin prescription < 540 days during a 2-year window time was associated with a higher risk for incidence of AD compared to statin non-use. However, days of prescription ≥ 540 and cumulative defined daily dose ≥ 540 of statin were associated with decreased risk of AD [aHR (95% CI) = 0.87 (0.80–0.95) and 0.79 (0.68–0.92), respectively]. Our findings indicate that less persistent statin use is associated with increased risk of AD, whereas persistent and adherent statin use is associated with decreased risk of AD.Su-Min JeongDong Wook ShinTae Gon YooMi Hee ChoWooyoung JangJinkook LeeSangYun KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Su-Min Jeong Dong Wook Shin Tae Gon Yoo Mi Hee Cho Wooyoung Jang Jinkook Lee SangYun Kim Association between statin use and Alzheimer’s disease with dose response relationship
description	Abstract This study aimed to determine the dose–response relationship between the levels of statin exposure and the incidence of Alzheimer’s disease (AD). We included 119,013 Korean adults (≥ 60 years old) using a database from the Korean National Health Insurance Service (2002–2013). Statin exposure was treated as a time-varying variable. Incidence of AD was defined by the first claim code for AD with anti-Alzheimer drugs. AD occurred in 9467 cases during a median 7.2 years of follow-up. Overall, statin use was not associated with an increased risk of AD incidence [adjusted hazard ratio (aHR) = 1.04; 95% confidence interval (CI) = 0.99–1.10]. When examined by level of statin exposure, statin prescription < 540 days during a 2-year window time was associated with a higher risk for incidence of AD compared to statin non-use. However, days of prescription ≥ 540 and cumulative defined daily dose ≥ 540 of statin were associated with decreased risk of AD [aHR (95% CI) = 0.87 (0.80–0.95) and 0.79 (0.68–0.92), respectively]. Our findings indicate that less persistent statin use is associated with increased risk of AD, whereas persistent and adherent statin use is associated with decreased risk of AD.
format	article
author	Su-Min Jeong Dong Wook Shin Tae Gon Yoo Mi Hee Cho Wooyoung Jang Jinkook Lee SangYun Kim
author_facet	Su-Min Jeong Dong Wook Shin Tae Gon Yoo Mi Hee Cho Wooyoung Jang Jinkook Lee SangYun Kim
author_sort	Su-Min Jeong
title	Association between statin use and Alzheimer’s disease with dose response relationship
title_short	Association between statin use and Alzheimer’s disease with dose response relationship
title_full	Association between statin use and Alzheimer’s disease with dose response relationship
title_fullStr	Association between statin use and Alzheimer’s disease with dose response relationship
title_full_unstemmed	Association between statin use and Alzheimer’s disease with dose response relationship
title_sort	association between statin use and alzheimer’s disease with dose response relationship
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b139a4a5764d42ceac5012d84c718bcc
work_keys_str_mv	AT suminjeong associationbetweenstatinuseandalzheimersdiseasewithdoseresponserelationship AT dongwookshin associationbetweenstatinuseandalzheimersdiseasewithdoseresponserelationship AT taegonyoo associationbetweenstatinuseandalzheimersdiseasewithdoseresponserelationship AT miheecho associationbetweenstatinuseandalzheimersdiseasewithdoseresponserelationship AT wooyoungjang associationbetweenstatinuseandalzheimersdiseasewithdoseresponserelationship AT jinkooklee associationbetweenstatinuseandalzheimersdiseasewithdoseresponserelationship AT sangyunkim associationbetweenstatinuseandalzheimersdiseasewithdoseresponserelationship
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Association between statin use and Alzheimer’s disease with dose response relationship

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