Modulation of Hoogsteen dynamics on DNA recognition

DNA is found in a dynamic equilibrium between standard Watson-Crick (WC) base pairs and non-standard Hoogsteen (HG) base pairs. Here the authors describe the influence of echinomycin and actinomycin D ligands binding on the HG-WC base pair dynamics in DNA.

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Bibliographic Details
Main Authors: Yu Xu, James McSally, Ioan Andricioaei, Hashim M. Al-Hashimi
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Q
Online Access:https://doaj.org/article/b13b41ea233f4bdb8b17d86942bc33d6
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