Prediction and Biochemical Demonstration of a Catabolic Pathway for the Osmoprotectant Proline Betaine

Prediction and Biochemical Demonstration of a Catabolic Pathway for the Osmoprotectant Proline Betaine

ABSTRACT Through the use of genetic, enzymatic, metabolomic, and structural analyses, we have discovered the catabolic pathway for proline betaine, an osmoprotectant, in Paracoccus denitrificans and Rhodobacter sphaeroides. Genetic and enzymatic analyses showed that several of the key enzymes of the...

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Autores principales: Ritesh Kumar, Suwen Zhao, Matthew W. Vetting, B. McKay Wood, Ayano Sakai, Kyuil Cho, José Solbiati, Steven C. Almo, Jonathan V. Sweedler, Matthew P. Jacobson, John A. Gerlt, John E. Cronan
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2014
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/b13b4ca1a7f9489490ef07a83617a9d7
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