Genetic deficiency of NOD2 confers resistance to invasive aspergillosis
NOD2 has been shown to be crucial for immune recognition of Aspergillus infection. Here the authors show that a common NOD2 genetic variant associated with Crohn’s disease is associated with reduced risk of disease due to enhanced antifungal activates of monocytes and macrophages.
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Nature Portfolio
2018
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oai:doaj.org-article:b13bbdc0097e4f22afcd8c24f2411e032021-12-02T14:39:26ZGenetic deficiency of NOD2 confers resistance to invasive aspergillosis10.1038/s41467-018-04912-32041-1723https://doaj.org/article/b13bbdc0097e4f22afcd8c24f2411e032018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04912-3https://doaj.org/toc/2041-1723NOD2 has been shown to be crucial for immune recognition of Aspergillus infection. Here the authors show that a common NOD2 genetic variant associated with Crohn’s disease is associated with reduced risk of disease due to enhanced antifungal activates of monocytes and macrophages.Mark S. GresnigtCristina CunhaMartin JaegerSamuel M. GonçalvesR. K. Subbarao MalireddiAnne AmmerdorfferRosalie LubbersMarije OostingOrhan RasidGrégory JouvionCatherine FittingDirk J. de JongJoão F. LacerdaAntónio CamposWillem J. G. MelchersKatrien LagrouJohan MaertensThirumala-Devi KannegantiAgostinho CarvalhoOumaima Ibrahim-GranetFrank L. van de VeerdonkNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Mark S. Gresnigt Cristina Cunha Martin Jaeger Samuel M. Gonçalves R. K. Subbarao Malireddi Anne Ammerdorffer Rosalie Lubbers Marije Oosting Orhan Rasid Grégory Jouvion Catherine Fitting Dirk J. de Jong João F. Lacerda António Campos Willem J. G. Melchers Katrien Lagrou Johan Maertens Thirumala-Devi Kanneganti Agostinho Carvalho Oumaima Ibrahim-Granet Frank L. van de Veerdonk Genetic deficiency of NOD2 confers resistance to invasive aspergillosis |
| description |
NOD2 has been shown to be crucial for immune recognition of Aspergillus infection. Here the authors show that a common NOD2 genetic variant associated with Crohn’s disease is associated with reduced risk of disease due to enhanced antifungal activates of monocytes and macrophages. |
| format |
article |
| author |
Mark S. Gresnigt Cristina Cunha Martin Jaeger Samuel M. Gonçalves R. K. Subbarao Malireddi Anne Ammerdorffer Rosalie Lubbers Marije Oosting Orhan Rasid Grégory Jouvion Catherine Fitting Dirk J. de Jong João F. Lacerda António Campos Willem J. G. Melchers Katrien Lagrou Johan Maertens Thirumala-Devi Kanneganti Agostinho Carvalho Oumaima Ibrahim-Granet Frank L. van de Veerdonk |
| author_facet |
Mark S. Gresnigt Cristina Cunha Martin Jaeger Samuel M. Gonçalves R. K. Subbarao Malireddi Anne Ammerdorffer Rosalie Lubbers Marije Oosting Orhan Rasid Grégory Jouvion Catherine Fitting Dirk J. de Jong João F. Lacerda António Campos Willem J. G. Melchers Katrien Lagrou Johan Maertens Thirumala-Devi Kanneganti Agostinho Carvalho Oumaima Ibrahim-Granet Frank L. van de Veerdonk |
| author_sort |
Mark S. Gresnigt |
| title |
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis |
| title_short |
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis |
| title_full |
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis |
| title_fullStr |
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis |
| title_full_unstemmed |
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis |
| title_sort |
genetic deficiency of nod2 confers resistance to invasive aspergillosis |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/b13bbdc0097e4f22afcd8c24f2411e03 |
| work_keys_str_mv |
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1718390611887783936 |