LncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad4

Highlights 1. Up-regulated levels of NNT-AS1 and smad4 in DN samples and HGMCs was manifested. 2. Potential binding sites of NNT-AS1 showed miR-214-5p as its direct target and NNT-AS1 as potential absorber for this microRNA, in turn increasing the expression of transcription factor smad4. 3. The res...

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Autores principales:	Zhuang Geng, Xiang Wang, Shiyuan Hao, Bingzi Dong, Yajing Huang, Yangang Wang, Lili Xu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	NNT-AS1 Extracellular matrix Human mesangial cells miR-214-5p smad4 Diabetic nephropathy Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/b13bea3225db40acb3b04d6e63e7588f
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spelling	oai:doaj.org-article:b13bea3225db40acb3b04d6e63e7588f2021-11-08T11:17:59ZLncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad410.1186/s12882-021-02580-y1471-2369https://doaj.org/article/b13bea3225db40acb3b04d6e63e7588f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12882-021-02580-yhttps://doaj.org/toc/1471-2369Highlights 1. Up-regulated levels of NNT-AS1 and smad4 in DN samples and HGMCs was manifested. 2. Potential binding sites of NNT-AS1 showed miR-214-5p as its direct target and NNT-AS1 as potential absorber for this microRNA, in turn increasing the expression of transcription factor smad4. 3. The results manifested that knocking-down NNT-AS1 can significantly decrease the inflammation and progression of DN and hence can be used as a potential therapeutic target.Zhuang GengXiang WangShiyuan HaoBingzi DongYajing HuangYangang WangLili XuBMCarticleNNT-AS1Extracellular matrixHuman mesangial cellsmiR-214-5psmad4Diabetic nephropathyDiseases of the genitourinary system. UrologyRC870-923ENBMC Nephrology, Vol 22, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NNT-AS1 Extracellular matrix Human mesangial cells miR-214-5p smad4 Diabetic nephropathy Diseases of the genitourinary system. Urology RC870-923
spellingShingle	NNT-AS1 Extracellular matrix Human mesangial cells miR-214-5p smad4 Diabetic nephropathy Diseases of the genitourinary system. Urology RC870-923 Zhuang Geng Xiang Wang Shiyuan Hao Bingzi Dong Yajing Huang Yangang Wang Lili Xu LncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad4
description	Highlights 1. Up-regulated levels of NNT-AS1 and smad4 in DN samples and HGMCs was manifested. 2. Potential binding sites of NNT-AS1 showed miR-214-5p as its direct target and NNT-AS1 as potential absorber for this microRNA, in turn increasing the expression of transcription factor smad4. 3. The results manifested that knocking-down NNT-AS1 can significantly decrease the inflammation and progression of DN and hence can be used as a potential therapeutic target.
format	article
author	Zhuang Geng Xiang Wang Shiyuan Hao Bingzi Dong Yajing Huang Yangang Wang Lili Xu
author_facet	Zhuang Geng Xiang Wang Shiyuan Hao Bingzi Dong Yajing Huang Yangang Wang Lili Xu
author_sort	Zhuang Geng
title	LncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad4
title_short	LncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad4
title_full	LncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad4
title_fullStr	LncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad4
title_full_unstemmed	LncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad4
title_sort	lncrna nnt-as1 regulates proliferation, ecm accumulation and inflammation of human mesangial cells induced by high glucose through mir-214-5p/smad4
publisher	BMC
publishDate	2021
url	https://doaj.org/article/b13bea3225db40acb3b04d6e63e7588f
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LncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad4

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