LncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad4

LncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad4

Highlights 1. Up-regulated levels of NNT-AS1 and smad4 in DN samples and HGMCs was manifested. 2. Potential binding sites of NNT-AS1 showed miR-214-5p as its direct target and NNT-AS1 as potential absorber for this microRNA, in turn increasing the expression of transcription factor smad4. 3. The res...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhuang Geng, Xiang Wang, Shiyuan Hao, Bingzi Dong, Yajing Huang, Yangang Wang, Lili Xu
Format: article
Language:EN
Published: BMC 2021
Subjects:
NNT-AS1
Extracellular matrix
Human mesangial cells
miR-214-5p
smad4
Diabetic nephropathy
Diseases of the genitourinary system. Urology
RC870-923
Online Access:https://doaj.org/article/b13bea3225db40acb3b04d6e63e7588f
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/b13bea3225db40acb3b04d6e63e7588f

Similar Items