African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations
While recent advances in genetics make it possible to follow the genetic exchanges between populations and their phenotypic consequences, the impact of the genetic exchanges on the sensory perception of populations has yet to be explored. From this perspective, the present study investigated the con...
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oai:doaj.org-article:b13ca22dfc514911bb12a5b4e7c89aa82021-11-25T16:56:40ZAfrican Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations10.3390/brainsci111114052076-3425https://doaj.org/article/b13ca22dfc514911bb12a5b4e7c89aa82021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1405https://doaj.org/toc/2076-3425While recent advances in genetics make it possible to follow the genetic exchanges between populations and their phenotypic consequences, the impact of the genetic exchanges on the sensory perception of populations has yet to be explored. From this perspective, the present study investigated the consequences of African gene flow on odor perception in a Malagasy population with a predominantly East Asian genetic background. To this end, we combined psychophysical tests with genotype data of 235 individuals who were asked to smell the odorant molecule beta-ionone (βI). Results showed that in this population the ancestry of the OR5A1 gene significantly influences the ability to detect βI. At the individual level, African ancestry significantly protects against specific anosmia/hyposmia due to the higher frequency of the functional gene (OR ratios = 14, CI: 1.8–110, <i>p</i>-value = 0.012). At the population level, African introgression decreased the prevalence of specific anosmia/hyposmia to this odorous compound. Taken together, these findings validate the conjecture that in addition to cultural exchanges, genetic transfer may also influence the sensory perception of the population in contact.Harilanto RazafindrazakaVeronica Pereda-LothCamille FerdenziMargit HeiskeOmar AlvaMinah RandriamialisoaCaroline CostedoatMichel SignoliThierry TalouMonique Courtade-SaidiAnne BolandJean-François DeleuzeCatherine RoubyChantal RadimilahyThierry LetellierMoustafa BensafiDenis PierronMDPI AGarticleadmixturebeta-iononeolfactionspecific anosmiaMadagascarNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1405, p 1405 (2021) |
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| topic |
admixture beta-ionone olfaction specific anosmia Madagascar Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
| spellingShingle |
admixture beta-ionone olfaction specific anosmia Madagascar Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Harilanto Razafindrazaka Veronica Pereda-Loth Camille Ferdenzi Margit Heiske Omar Alva Minah Randriamialisoa Caroline Costedoat Michel Signoli Thierry Talou Monique Courtade-Saidi Anne Boland Jean-François Deleuze Catherine Rouby Chantal Radimilahy Thierry Letellier Moustafa Bensafi Denis Pierron African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations |
| description |
While recent advances in genetics make it possible to follow the genetic exchanges between populations and their phenotypic consequences, the impact of the genetic exchanges on the sensory perception of populations has yet to be explored. From this perspective, the present study investigated the consequences of African gene flow on odor perception in a Malagasy population with a predominantly East Asian genetic background. To this end, we combined psychophysical tests with genotype data of 235 individuals who were asked to smell the odorant molecule beta-ionone (βI). Results showed that in this population the ancestry of the OR5A1 gene significantly influences the ability to detect βI. At the individual level, African ancestry significantly protects against specific anosmia/hyposmia due to the higher frequency of the functional gene (OR ratios = 14, CI: 1.8–110, <i>p</i>-value = 0.012). At the population level, African introgression decreased the prevalence of specific anosmia/hyposmia to this odorous compound. Taken together, these findings validate the conjecture that in addition to cultural exchanges, genetic transfer may also influence the sensory perception of the population in contact. |
| format |
article |
| author |
Harilanto Razafindrazaka Veronica Pereda-Loth Camille Ferdenzi Margit Heiske Omar Alva Minah Randriamialisoa Caroline Costedoat Michel Signoli Thierry Talou Monique Courtade-Saidi Anne Boland Jean-François Deleuze Catherine Rouby Chantal Radimilahy Thierry Letellier Moustafa Bensafi Denis Pierron |
| author_facet |
Harilanto Razafindrazaka Veronica Pereda-Loth Camille Ferdenzi Margit Heiske Omar Alva Minah Randriamialisoa Caroline Costedoat Michel Signoli Thierry Talou Monique Courtade-Saidi Anne Boland Jean-François Deleuze Catherine Rouby Chantal Radimilahy Thierry Letellier Moustafa Bensafi Denis Pierron |
| author_sort |
Harilanto Razafindrazaka |
| title |
African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations |
| title_short |
African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations |
| title_full |
African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations |
| title_fullStr |
African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations |
| title_full_unstemmed |
African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations |
| title_sort |
african gene flow reduces beta-ionone anosmia/hyposmia prevalence in admixed malagasy populations |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/b13ca22dfc514911bb12a5b4e7c89aa8 |
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