Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows

Background and Aim: Digital dermatitis (DD) is one of the most common causes of lameness in dairy cattle. It is seen in nearly all dairy herds across the world and has substantial welfare and economic implications. In this study, we aimed to investigate the efficacy of phenytoin sodium topical treat...

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Autores principales:	El-Sayed El-Shafaey, Mohamed A. Hamed, Eman Abo Elfadl, Naglaa A. Gomaa, Mohamed Abdo Rizk
Formato:	article
Lenguaje:	EN
Publicado:	Veterinary World 2021
Materias:	chlortetracycline cows digital dermatitis phenytoin Animal culture SF1-1100 Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/b13d64663e534e519c75b2c8b1e10655
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spelling	oai:doaj.org-article:b13d64663e534e519c75b2c8b1e106552021-11-12T04:33:26ZPhenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows10.14202/vetworld.2021.2907-29120972-89882231-0916https://doaj.org/article/b13d64663e534e519c75b2c8b1e106552021-11-01T00:00:00Zhttp://www.veterinaryworld.org/Vol.14/November-2021/9.pdfhttps://doaj.org/toc/0972-8988https://doaj.org/toc/2231-0916Background and Aim: Digital dermatitis (DD) is one of the most common causes of lameness in dairy cattle. It is seen in nearly all dairy herds across the world and has substantial welfare and economic implications. In this study, we aimed to investigate the efficacy of phenytoin sodium topical treatment on painful ulcerative stage of bovine digital dermatitis (BDD). Materials and Methods: In total, 45 Holstein-Friesian dairy cows with DD were randomly assigned to one of the three topical treatment trials (15 each): Saline solution (first treatment, negative control), chlortetracycline spray (second treatment, positive control), or phenytoin sodium powder (third treatment, positive control) (third treatment). On day 0 (pre-treatment) and on days 7, 14, 21, and 28 post-treatment, the response of DD-affected cows to the medications used was evaluated by measuring lesion depth and size, as well as the total clinical score (lameness, pain, and discomfort). Results: The cure rate in cows treated with phenytoin (86.66%) on day 28 was significantly improved compared to cows treated with either chlortetracycline (60%) or normal saline (6.66 %). Conclusion: Our findings highlight the superiority of phenytoin over the commonly used antibacterial agent, chlortetracycline, in the topical treatment of BDD, and subsequently suggest that phenytoin should be considered a suitable alternative treatment option for the treatment of BDD.El-Sayed El-ShafaeyMohamed A. HamedEman Abo ElfadlNaglaa A. GomaaMohamed Abdo RizkVeterinary Worldarticlechlortetracyclinecowsdigital dermatitisphenytoinAnimal cultureSF1-1100Veterinary medicineSF600-1100ENVeterinary World, Vol 14, Iss 11, Pp 2907-2912 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chlortetracycline cows digital dermatitis phenytoin Animal culture SF1-1100 Veterinary medicine SF600-1100
spellingShingle	chlortetracycline cows digital dermatitis phenytoin Animal culture SF1-1100 Veterinary medicine SF600-1100 El-Sayed El-Shafaey Mohamed A. Hamed Eman Abo Elfadl Naglaa A. Gomaa Mohamed Abdo Rizk Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows
description	Background and Aim: Digital dermatitis (DD) is one of the most common causes of lameness in dairy cattle. It is seen in nearly all dairy herds across the world and has substantial welfare and economic implications. In this study, we aimed to investigate the efficacy of phenytoin sodium topical treatment on painful ulcerative stage of bovine digital dermatitis (BDD). Materials and Methods: In total, 45 Holstein-Friesian dairy cows with DD were randomly assigned to one of the three topical treatment trials (15 each): Saline solution (first treatment, negative control), chlortetracycline spray (second treatment, positive control), or phenytoin sodium powder (third treatment, positive control) (third treatment). On day 0 (pre-treatment) and on days 7, 14, 21, and 28 post-treatment, the response of DD-affected cows to the medications used was evaluated by measuring lesion depth and size, as well as the total clinical score (lameness, pain, and discomfort). Results: The cure rate in cows treated with phenytoin (86.66%) on day 28 was significantly improved compared to cows treated with either chlortetracycline (60%) or normal saline (6.66 %). Conclusion: Our findings highlight the superiority of phenytoin over the commonly used antibacterial agent, chlortetracycline, in the topical treatment of BDD, and subsequently suggest that phenytoin should be considered a suitable alternative treatment option for the treatment of BDD.
format	article
author	El-Sayed El-Shafaey Mohamed A. Hamed Eman Abo Elfadl Naglaa A. Gomaa Mohamed Abdo Rizk
author_facet	El-Sayed El-Shafaey Mohamed A. Hamed Eman Abo Elfadl Naglaa A. Gomaa Mohamed Abdo Rizk
author_sort	El-Sayed El-Shafaey
title	Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows
title_short	Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows
title_full	Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows
title_fullStr	Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows
title_full_unstemmed	Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows
title_sort	phenytoin: a promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows
publisher	Veterinary World
publishDate	2021
url	https://doaj.org/article/b13d64663e534e519c75b2c8b1e10655
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Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows

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