Blunted natriuretic response to saline loading in sheep with hypertensive kidney disease following radiofrequency catheter-based renal denervation

Abstract Renal sympathetic nerves contribute to renal excretory function during volume expansion. We hypothesized that intact renal innervation is required for excretion of a fluid/electrolyte load in hypertensive chronic kidney disease (CKD) and normotensive healthy settings. Blood pressure, kidney...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Reetu R. Singh, Zoe McArdle, Harshil Singh, Lindsea C. Booth, Clive N. May, Geoffrey A. Head, Karen M. Moritz, Markus P. Schlaich, Kate M. Denton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b13e539237454fc69489a5ca369b4622
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b13e539237454fc69489a5ca369b4622
record_format	dspace
spelling	oai:doaj.org-article:b13e539237454fc69489a5ca369b46222021-12-02T16:50:24ZBlunted natriuretic response to saline loading in sheep with hypertensive kidney disease following radiofrequency catheter-based renal denervation10.1038/s41598-021-94221-52045-2322https://doaj.org/article/b13e539237454fc69489a5ca369b46222021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94221-5https://doaj.org/toc/2045-2322Abstract Renal sympathetic nerves contribute to renal excretory function during volume expansion. We hypothesized that intact renal innervation is required for excretion of a fluid/electrolyte load in hypertensive chronic kidney disease (CKD) and normotensive healthy settings. Blood pressure, kidney hemodynamic and excretory response to 180 min of isotonic saline loading (0.13 ml/kg/min) were examined in female normotensive (control) and hypertensive CKD sheep at 2 and 11 months after sham (control-intact, CKD-intact) or radiofrequency catheter-based RDN (control-RDN, CKD-RDN) procedure. Basal blood pressure was ~ 7 to 9 mmHg lower at 2, and 11 months in CKD-RDN compared with CKD-intact sheep. Saline loading did not alter glomerular filtration rate in any group. At 2 months, in response to saline loading, total urine and sodium excretion were ~ 40 to 50% less, in control-RDN and CKD-RDN than intact groups. At 11 months, the natriuretic and diuretic response to saline loading were similar between control-intact, control-RDN and CKD-intact groups but sodium excretion was ~ 42% less in CKD-RDN compared with CKD-intact at this time-point. These findings indicate that chronic withdrawal of basal renal sympathetic activity impairs fluid/electrolyte excretion during volume expansion. Clinically, a reduced ability to excrete a saline load following RDN may contribute to disturbances in body fluid balance in hypertensive CKD.Reetu R. SinghZoe McArdleHarshil SinghLindsea C. BoothClive N. MayGeoffrey A. HeadKaren M. MoritzMarkus P. SchlaichKate M. DentonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Reetu R. Singh Zoe McArdle Harshil Singh Lindsea C. Booth Clive N. May Geoffrey A. Head Karen M. Moritz Markus P. Schlaich Kate M. Denton Blunted natriuretic response to saline loading in sheep with hypertensive kidney disease following radiofrequency catheter-based renal denervation
description	Abstract Renal sympathetic nerves contribute to renal excretory function during volume expansion. We hypothesized that intact renal innervation is required for excretion of a fluid/electrolyte load in hypertensive chronic kidney disease (CKD) and normotensive healthy settings. Blood pressure, kidney hemodynamic and excretory response to 180 min of isotonic saline loading (0.13 ml/kg/min) were examined in female normotensive (control) and hypertensive CKD sheep at 2 and 11 months after sham (control-intact, CKD-intact) or radiofrequency catheter-based RDN (control-RDN, CKD-RDN) procedure. Basal blood pressure was ~ 7 to 9 mmHg lower at 2, and 11 months in CKD-RDN compared with CKD-intact sheep. Saline loading did not alter glomerular filtration rate in any group. At 2 months, in response to saline loading, total urine and sodium excretion were ~ 40 to 50% less, in control-RDN and CKD-RDN than intact groups. At 11 months, the natriuretic and diuretic response to saline loading were similar between control-intact, control-RDN and CKD-intact groups but sodium excretion was ~ 42% less in CKD-RDN compared with CKD-intact at this time-point. These findings indicate that chronic withdrawal of basal renal sympathetic activity impairs fluid/electrolyte excretion during volume expansion. Clinically, a reduced ability to excrete a saline load following RDN may contribute to disturbances in body fluid balance in hypertensive CKD.
format	article
author	Reetu R. Singh Zoe McArdle Harshil Singh Lindsea C. Booth Clive N. May Geoffrey A. Head Karen M. Moritz Markus P. Schlaich Kate M. Denton
author_facet	Reetu R. Singh Zoe McArdle Harshil Singh Lindsea C. Booth Clive N. May Geoffrey A. Head Karen M. Moritz Markus P. Schlaich Kate M. Denton
author_sort	Reetu R. Singh
title	Blunted natriuretic response to saline loading in sheep with hypertensive kidney disease following radiofrequency catheter-based renal denervation
title_short	Blunted natriuretic response to saline loading in sheep with hypertensive kidney disease following radiofrequency catheter-based renal denervation
title_full	Blunted natriuretic response to saline loading in sheep with hypertensive kidney disease following radiofrequency catheter-based renal denervation
title_fullStr	Blunted natriuretic response to saline loading in sheep with hypertensive kidney disease following radiofrequency catheter-based renal denervation
title_full_unstemmed	Blunted natriuretic response to saline loading in sheep with hypertensive kidney disease following radiofrequency catheter-based renal denervation
title_sort	blunted natriuretic response to saline loading in sheep with hypertensive kidney disease following radiofrequency catheter-based renal denervation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b13e539237454fc69489a5ca369b4622
work_keys_str_mv	AT reetursingh bluntednatriureticresponsetosalineloadinginsheepwithhypertensivekidneydiseasefollowingradiofrequencycatheterbasedrenaldenervation AT zoemcardle bluntednatriureticresponsetosalineloadinginsheepwithhypertensivekidneydiseasefollowingradiofrequencycatheterbasedrenaldenervation AT harshilsingh bluntednatriureticresponsetosalineloadinginsheepwithhypertensivekidneydiseasefollowingradiofrequencycatheterbasedrenaldenervation AT lindseacbooth bluntednatriureticresponsetosalineloadinginsheepwithhypertensivekidneydiseasefollowingradiofrequencycatheterbasedrenaldenervation AT clivenmay bluntednatriureticresponsetosalineloadinginsheepwithhypertensivekidneydiseasefollowingradiofrequencycatheterbasedrenaldenervation AT geoffreyahead bluntednatriureticresponsetosalineloadinginsheepwithhypertensivekidneydiseasefollowingradiofrequencycatheterbasedrenaldenervation AT karenmmoritz bluntednatriureticresponsetosalineloadinginsheepwithhypertensivekidneydiseasefollowingradiofrequencycatheterbasedrenaldenervation AT markuspschlaich bluntednatriureticresponsetosalineloadinginsheepwithhypertensivekidneydiseasefollowingradiofrequencycatheterbasedrenaldenervation AT katemdenton bluntednatriureticresponsetosalineloadinginsheepwithhypertensivekidneydiseasefollowingradiofrequencycatheterbasedrenaldenervation
_version_	1718383058558648320

Blunted natriuretic response to saline loading in sheep with hypertensive kidney disease following radiofrequency catheter-based renal denervation

Ejemplares similares