Dysregulated transcriptional responses to SARS-CoV-2 in the periphery

Dysregulated transcriptional responses to SARS-CoV-2 in the periphery

The systemic immune features that distinguish COVID-19 from common infections remain incompletely elucidated. Here McClain et al. compare RNA sequencing in peripheral blood between subjects with SARS-CoV-2 and other respiratory infections and demonstrate dysregulated immune responses in COVID-19 wit...

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Autores principales: Micah T. McClain, Florica J. Constantine, Ricardo Henao, Yiling Liu, Ephraim L. Tsalik, Thomas W. Burke, Julie M. Steinbrink, Elizabeth Petzold, Bradly P. Nicholson, Robert Rolfe, Bryan D. Kraft, Matthew S. Kelly, Daniel R. Saban, Chen Yu, Xiling Shen, Emily M. Ko, Gregory D. Sempowski, Thomas N. Denny, Geoffrey S. Ginsburg, Christopher W. Woods
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b140cf38382d49ca96a5aa166526b245
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Sumario:The systemic immune features that distinguish COVID-19 from common infections remain incompletely elucidated. Here McClain et al. compare RNA sequencing in peripheral blood between subjects with SARS-CoV-2 and other respiratory infections and demonstrate dysregulated immune responses in COVID-19 with both heterogeneous and conserved components.

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