INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL

Abstract. Mediators of inflammation may play a sufficient role in destabilization of atherosclerotic plaque, disturbing the balance between collagen formation and its degradation in fibrotic capsule. Using a transgenic murine model, the effects of induced inflammation upon expression of factors dete...

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Autores principales:	E. V. Shlyakhto, N. A. Gavrisheva, O. A. Ovchinnikova, G. K. Hansson
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	atherosclerotic plaque inflammation collagen metalloproteinases murine model Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b14599d6e8bd46ada8b3b15770e9cd40
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spelling	oai:doaj.org-article:b14599d6e8bd46ada8b3b15770e9cd402021-11-18T08:03:39ZINFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL1563-06252313-741X10.15789/1563-0625-2008-6-507-512https://doaj.org/article/b14599d6e8bd46ada8b3b15770e9cd402014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/254https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Mediators of inflammation may play a sufficient role in destabilization of atherosclerotic plaque, disturbing the balance between collagen formation and its degradation in fibrotic capsule. Using a transgenic murine model, the effects of induced inflammation upon expression of factors determining posttranslational modification and degradation of collagen, i.e., prolyl-4-hydroxylase, matrix metalloproteinases-2, -9 (MMP-2, -9), and tissue inhibitor of metalloproteinases (TIMP-1) were evaluated. It has been shown that, under significant increase of interferon-γ and interleukin-1β, the synthesis of prolyl-4-hydroxylase and MMP - 9 is decreased, whereas expression of collagen, MMP-2 and TIMP-1 genes was not changed. (Med. Immunol., vol. 10, N 6, pp 507-512).E. V. ShlyakhtoN. A. GavrishevaO. A. OvchinnikovaG. K. HanssonSPb RAACIarticleatherosclerotic plaqueinflammationcollagenmetalloproteinasesmurine modelImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 6, Pp 507-512 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	atherosclerotic plaque inflammation collagen metalloproteinases murine model Immunologic diseases. Allergy RC581-607
spellingShingle	atherosclerotic plaque inflammation collagen metalloproteinases murine model Immunologic diseases. Allergy RC581-607 E. V. Shlyakhto N. A. Gavrisheva O. A. Ovchinnikova G. K. Hansson INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL
description	Abstract. Mediators of inflammation may play a sufficient role in destabilization of atherosclerotic plaque, disturbing the balance between collagen formation and its degradation in fibrotic capsule. Using a transgenic murine model, the effects of induced inflammation upon expression of factors determining posttranslational modification and degradation of collagen, i.e., prolyl-4-hydroxylase, matrix metalloproteinases-2, -9 (MMP-2, -9), and tissue inhibitor of metalloproteinases (TIMP-1) were evaluated. It has been shown that, under significant increase of interferon-γ and interleukin-1β, the synthesis of prolyl-4-hydroxylase and MMP - 9 is decreased, whereas expression of collagen, MMP-2 and TIMP-1 genes was not changed. (Med. Immunol., vol. 10, N 6, pp 507-512).
format	article
author	E. V. Shlyakhto N. A. Gavrisheva O. A. Ovchinnikova G. K. Hansson
author_facet	E. V. Shlyakhto N. A. Gavrisheva O. A. Ovchinnikova G. K. Hansson
author_sort	E. V. Shlyakhto
title	INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL
title_short	INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL
title_full	INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL
title_fullStr	INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL
title_full_unstemmed	INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL
title_sort	influence of induced inflammation upon collagen metabolism of unstable atherosclerotic plaque in murine model
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b14599d6e8bd46ada8b3b15770e9cd40
work_keys_str_mv	AT evshlyakhto influenceofinducedinflammationuponcollagenmetabolismofunstableatheroscleroticplaqueinmurinemodel AT nagavrisheva influenceofinducedinflammationuponcollagenmetabolismofunstableatheroscleroticplaqueinmurinemodel AT oaovchinnikova influenceofinducedinflammationuponcollagenmetabolismofunstableatheroscleroticplaqueinmurinemodel AT gkhansson influenceofinducedinflammationuponcollagenmetabolismofunstableatheroscleroticplaqueinmurinemodel
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INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL

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