Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression
Aβ34 is generated from degradation of Aβ40 and Aβ42 by β-secretase. Here, the authors show that Aβ34 is a marker for amyloid clearance and is elevated in the CSF of patients that go on to convert from mild cognitive impairment to Alzheimer’s disease, suggesting it may be a useful biomarker.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b145f3c2811a4f8c9097430d26ff9fe5 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:b145f3c2811a4f8c9097430d26ff9fe5 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:b145f3c2811a4f8c9097430d26ff9fe52021-12-02T16:57:35ZAβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression10.1038/s41467-019-10152-w2041-1723https://doaj.org/article/b145f3c2811a4f8c9097430d26ff9fe52019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10152-whttps://doaj.org/toc/2041-1723Aβ34 is generated from degradation of Aβ40 and Aβ42 by β-secretase. Here, the authors show that Aβ34 is a marker for amyloid clearance and is elevated in the CSF of patients that go on to convert from mild cognitive impairment to Alzheimer’s disease, suggesting it may be a useful biomarker.Filip LiebschLuka KulicCharlotte TeunissenAdeola ShoboIrem UlkuVivienne EngelschaltMark A. HancockWiesje M. van der FlierPeter KunachPedro Rosa-NetoPhilip ScheltensJudes PoirierPaul SaftigRandall J. BatemanJohn BreitnerChristoph HockGerhard MulthaupNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Filip Liebsch Luka Kulic Charlotte Teunissen Adeola Shobo Irem Ulku Vivienne Engelschalt Mark A. Hancock Wiesje M. van der Flier Peter Kunach Pedro Rosa-Neto Philip Scheltens Judes Poirier Paul Saftig Randall J. Bateman John Breitner Christoph Hock Gerhard Multhaup Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression |
| description |
Aβ34 is generated from degradation of Aβ40 and Aβ42 by β-secretase. Here, the authors show that Aβ34 is a marker for amyloid clearance and is elevated in the CSF of patients that go on to convert from mild cognitive impairment to Alzheimer’s disease, suggesting it may be a useful biomarker. |
| format |
article |
| author |
Filip Liebsch Luka Kulic Charlotte Teunissen Adeola Shobo Irem Ulku Vivienne Engelschalt Mark A. Hancock Wiesje M. van der Flier Peter Kunach Pedro Rosa-Neto Philip Scheltens Judes Poirier Paul Saftig Randall J. Bateman John Breitner Christoph Hock Gerhard Multhaup |
| author_facet |
Filip Liebsch Luka Kulic Charlotte Teunissen Adeola Shobo Irem Ulku Vivienne Engelschalt Mark A. Hancock Wiesje M. van der Flier Peter Kunach Pedro Rosa-Neto Philip Scheltens Judes Poirier Paul Saftig Randall J. Bateman John Breitner Christoph Hock Gerhard Multhaup |
| author_sort |
Filip Liebsch |
| title |
Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression |
| title_short |
Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression |
| title_full |
Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression |
| title_fullStr |
Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression |
| title_full_unstemmed |
Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression |
| title_sort |
aβ34 is a bace1-derived degradation intermediate associated with amyloid clearance and alzheimer’s disease progression |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/b145f3c2811a4f8c9097430d26ff9fe5 |
| work_keys_str_mv |
AT filipliebsch ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT lukakulic ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT charlotteteunissen ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT adeolashobo ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT iremulku ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT vivienneengelschalt ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT markahancock ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT wiesjemvanderflier ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT peterkunach ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT pedrorosaneto ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT philipscheltens ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT judespoirier ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT paulsaftig ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT randalljbateman ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT johnbreitner ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT christophhock ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression AT gerhardmulthaup ab34isabace1deriveddegradationintermediateassociatedwithamyloidclearanceandalzheimersdiseaseprogression |
| _version_ |
1718382523255357440 |