Advances of Nanomedicine in Radiotherapy

Radiotherapy (RT) remains one of the current main treatment strategies for many types of cancer. However, how to improve RT efficiency while reducing its side effects is still a large challenge to be overcome. Advancements in nanomedicine have provided many effective approaches for radiosensitizatio...

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Autores principales:	Wei Liu, Bo Chen, Haocheng Zheng, Yun Xing, Guiyuan Chen, Peijie Zhou, Liting Qian, Yuanzeng Min
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	radiotherapy radiosensitization nanoparticles drug delivery immunotherapy Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/b1498187351d4e60ba78a617b6bee552
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spelling	oai:doaj.org-article:b1498187351d4e60ba78a617b6bee5522021-11-25T18:40:24ZAdvances of Nanomedicine in Radiotherapy10.3390/pharmaceutics131117571999-4923https://doaj.org/article/b1498187351d4e60ba78a617b6bee5522021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1757https://doaj.org/toc/1999-4923Radiotherapy (RT) remains one of the current main treatment strategies for many types of cancer. However, how to improve RT efficiency while reducing its side effects is still a large challenge to be overcome. Advancements in nanomedicine have provided many effective approaches for radiosensitization. Metal nanoparticles (NPs) such as platinum-based or hafnium-based NPs are proved to be ideal radiosensitizers because of their unique physicochemical properties and high X-ray absorption efficiency. With nanoparticles, such as liposomes, bovine serum albumin, and polymers, the radiosensitizing drugs can be promoted to reach the tumor sites, thereby enhancing anti-tumor responses. Nowadays, the combination of some NPs and RT have been applied to clinical treatment for many types of cancer, including breast cancer. Here, as well as reviewing recent studies on radiotherapy combined with inorganic, organic, and biomimetic nanomaterials for oncology, we analyzed the underlying mechanisms of NPs radiosensitization, which may contribute to exploring new directions for the clinical translation of nanoparticle-based radiosensitizers.Wei LiuBo ChenHaocheng ZhengYun XingGuiyuan ChenPeijie ZhouLiting QianYuanzeng MinMDPI AGarticleradiotherapyradiosensitizationnanoparticlesdrug deliveryimmunotherapyPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1757, p 1757 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radiotherapy radiosensitization nanoparticles drug delivery immunotherapy Pharmacy and materia medica RS1-441
spellingShingle	radiotherapy radiosensitization nanoparticles drug delivery immunotherapy Pharmacy and materia medica RS1-441 Wei Liu Bo Chen Haocheng Zheng Yun Xing Guiyuan Chen Peijie Zhou Liting Qian Yuanzeng Min Advances of Nanomedicine in Radiotherapy
description	Radiotherapy (RT) remains one of the current main treatment strategies for many types of cancer. However, how to improve RT efficiency while reducing its side effects is still a large challenge to be overcome. Advancements in nanomedicine have provided many effective approaches for radiosensitization. Metal nanoparticles (NPs) such as platinum-based or hafnium-based NPs are proved to be ideal radiosensitizers because of their unique physicochemical properties and high X-ray absorption efficiency. With nanoparticles, such as liposomes, bovine serum albumin, and polymers, the radiosensitizing drugs can be promoted to reach the tumor sites, thereby enhancing anti-tumor responses. Nowadays, the combination of some NPs and RT have been applied to clinical treatment for many types of cancer, including breast cancer. Here, as well as reviewing recent studies on radiotherapy combined with inorganic, organic, and biomimetic nanomaterials for oncology, we analyzed the underlying mechanisms of NPs radiosensitization, which may contribute to exploring new directions for the clinical translation of nanoparticle-based radiosensitizers.
format	article
author	Wei Liu Bo Chen Haocheng Zheng Yun Xing Guiyuan Chen Peijie Zhou Liting Qian Yuanzeng Min
author_facet	Wei Liu Bo Chen Haocheng Zheng Yun Xing Guiyuan Chen Peijie Zhou Liting Qian Yuanzeng Min
author_sort	Wei Liu
title	Advances of Nanomedicine in Radiotherapy
title_short	Advances of Nanomedicine in Radiotherapy
title_full	Advances of Nanomedicine in Radiotherapy
title_fullStr	Advances of Nanomedicine in Radiotherapy
title_full_unstemmed	Advances of Nanomedicine in Radiotherapy
title_sort	advances of nanomedicine in radiotherapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b1498187351d4e60ba78a617b6bee552
work_keys_str_mv	AT weiliu advancesofnanomedicineinradiotherapy AT bochen advancesofnanomedicineinradiotherapy AT haochengzheng advancesofnanomedicineinradiotherapy AT yunxing advancesofnanomedicineinradiotherapy AT guiyuanchen advancesofnanomedicineinradiotherapy AT peijiezhou advancesofnanomedicineinradiotherapy AT litingqian advancesofnanomedicineinradiotherapy AT yuanzengmin advancesofnanomedicineinradiotherapy
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Advances of Nanomedicine in Radiotherapy

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