The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis

TOP1MT is a topoisomerase that is localised to mitochondria. Here, the authors show that TOP1MT has a tumor promoting role in hepatocellular carcinoma by supporting mitochondrial translation and that its deficiency limits tumorigenicity.

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Autores principales:	S. A. Baechler, V. M. Factor, I. Dalla Rosa, A. Ravji, D. Becker, S. Khiati, L. M. Miller Jenkins, M. Lang, C. Sourbier, S. A. Michaels, L. M. Neckers, H. L. Zhang, A. Spinazzola, S. N. Huang, J. U. Marquardt, Y. Pommier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b1503d7453304fa591b1cf607669d4c1
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spelling	oai:doaj.org-article:b1503d7453304fa591b1cf607669d4c12021-12-02T14:39:56ZThe mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis10.1038/s41467-018-07922-32041-1723https://doaj.org/article/b1503d7453304fa591b1cf607669d4c12019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07922-3https://doaj.org/toc/2041-1723TOP1MT is a topoisomerase that is localised to mitochondria. Here, the authors show that TOP1MT has a tumor promoting role in hepatocellular carcinoma by supporting mitochondrial translation and that its deficiency limits tumorigenicity.S. A. BaechlerV. M. FactorI. Dalla RosaA. RavjiD. BeckerS. KhiatiL. M. Miller JenkinsM. LangC. SourbierS. A. MichaelsL. M. NeckersH. L. ZhangA. SpinazzolaS. N. HuangJ. U. MarquardtY. PommierNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q S. A. Baechler V. M. Factor I. Dalla Rosa A. Ravji D. Becker S. Khiati L. M. Miller Jenkins M. Lang C. Sourbier S. A. Michaels L. M. Neckers H. L. Zhang A. Spinazzola S. N. Huang J. U. Marquardt Y. Pommier The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis
description	TOP1MT is a topoisomerase that is localised to mitochondria. Here, the authors show that TOP1MT has a tumor promoting role in hepatocellular carcinoma by supporting mitochondrial translation and that its deficiency limits tumorigenicity.
format	article
author	S. A. Baechler V. M. Factor I. Dalla Rosa A. Ravji D. Becker S. Khiati L. M. Miller Jenkins M. Lang C. Sourbier S. A. Michaels L. M. Neckers H. L. Zhang A. Spinazzola S. N. Huang J. U. Marquardt Y. Pommier
author_facet	S. A. Baechler V. M. Factor I. Dalla Rosa A. Ravji D. Becker S. Khiati L. M. Miller Jenkins M. Lang C. Sourbier S. A. Michaels L. M. Neckers H. L. Zhang A. Spinazzola S. N. Huang J. U. Marquardt Y. Pommier
author_sort	S. A. Baechler
title	The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis
title_short	The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis
title_full	The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis
title_fullStr	The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis
title_full_unstemmed	The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis
title_sort	mitochondrial type ib topoisomerase drives mitochondrial translation and carcinogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b1503d7453304fa591b1cf607669d4c1
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The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis

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