Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes

Interactions between germline variants and somatic mutations is a relatively unexplored topic in cancer. Here, in Ewing sarcoma, the authors show that binding of the oncogenic EWSR1-FLI1 fusion transcription factor to a polymorphic enhancer-like DNA element controls MYBL2, whose high expression corr...

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Autores principales:	Julian Musa, Florencia Cidre-Aranaz, Marie-Ming Aynaud, Martin F. Orth, Maximilian M. L. Knott, Olivier Mirabeau, Gal Mazor, Mor Varon, Tilman L. B. Hölting, Sandrine Grossetête, Moritz Gartlgruber, Didier Surdez, Julia S. Gerke, Shunya Ohmura, Aruna Marchetto, Marlene Dallmayer, Michaela C. Baldauf, Stefanie Stein, Giuseppina Sannino, Jing Li, Laura Romero-Pérez, Frank Westermann, Wolfgang Hartmann, Uta Dirksen, Melissa Gymrek, Nathaniel D. Anderson, Adam Shlien, Barak Rotblat, Thomas Kirchner, Olivier Delattre, Thomas G. P. Grünewald
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b15283577e6941feafb9a8d8c4019ddd
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spelling	oai:doaj.org-article:b15283577e6941feafb9a8d8c4019ddd2021-12-02T17:01:46ZCooperation of cancer drivers with regulatory germline variants shapes clinical outcomes10.1038/s41467-019-12071-22041-1723https://doaj.org/article/b15283577e6941feafb9a8d8c4019ddd2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12071-2https://doaj.org/toc/2041-1723Interactions between germline variants and somatic mutations is a relatively unexplored topic in cancer. Here, in Ewing sarcoma, the authors show that binding of the oncogenic EWSR1-FLI1 fusion transcription factor to a polymorphic enhancer-like DNA element controls MYBL2, whose high expression correlates with prognosis.Julian MusaFlorencia Cidre-AranazMarie-Ming AynaudMartin F. OrthMaximilian M. L. KnottOlivier MirabeauGal MazorMor VaronTilman L. B. HöltingSandrine GrossetêteMoritz GartlgruberDidier SurdezJulia S. GerkeShunya OhmuraAruna MarchettoMarlene DallmayerMichaela C. BaldaufStefanie SteinGiuseppina SanninoJing LiLaura Romero-PérezFrank WestermannWolfgang HartmannUta DirksenMelissa GymrekNathaniel D. AndersonAdam ShlienBarak RotblatThomas KirchnerOlivier DelattreThomas G. P. GrünewaldNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julian Musa Florencia Cidre-Aranaz Marie-Ming Aynaud Martin F. Orth Maximilian M. L. Knott Olivier Mirabeau Gal Mazor Mor Varon Tilman L. B. Hölting Sandrine Grossetête Moritz Gartlgruber Didier Surdez Julia S. Gerke Shunya Ohmura Aruna Marchetto Marlene Dallmayer Michaela C. Baldauf Stefanie Stein Giuseppina Sannino Jing Li Laura Romero-Pérez Frank Westermann Wolfgang Hartmann Uta Dirksen Melissa Gymrek Nathaniel D. Anderson Adam Shlien Barak Rotblat Thomas Kirchner Olivier Delattre Thomas G. P. Grünewald Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
description	Interactions between germline variants and somatic mutations is a relatively unexplored topic in cancer. Here, in Ewing sarcoma, the authors show that binding of the oncogenic EWSR1-FLI1 fusion transcription factor to a polymorphic enhancer-like DNA element controls MYBL2, whose high expression correlates with prognosis.
format	article
author	Julian Musa Florencia Cidre-Aranaz Marie-Ming Aynaud Martin F. Orth Maximilian M. L. Knott Olivier Mirabeau Gal Mazor Mor Varon Tilman L. B. Hölting Sandrine Grossetête Moritz Gartlgruber Didier Surdez Julia S. Gerke Shunya Ohmura Aruna Marchetto Marlene Dallmayer Michaela C. Baldauf Stefanie Stein Giuseppina Sannino Jing Li Laura Romero-Pérez Frank Westermann Wolfgang Hartmann Uta Dirksen Melissa Gymrek Nathaniel D. Anderson Adam Shlien Barak Rotblat Thomas Kirchner Olivier Delattre Thomas G. P. Grünewald
author_facet	Julian Musa Florencia Cidre-Aranaz Marie-Ming Aynaud Martin F. Orth Maximilian M. L. Knott Olivier Mirabeau Gal Mazor Mor Varon Tilman L. B. Hölting Sandrine Grossetête Moritz Gartlgruber Didier Surdez Julia S. Gerke Shunya Ohmura Aruna Marchetto Marlene Dallmayer Michaela C. Baldauf Stefanie Stein Giuseppina Sannino Jing Li Laura Romero-Pérez Frank Westermann Wolfgang Hartmann Uta Dirksen Melissa Gymrek Nathaniel D. Anderson Adam Shlien Barak Rotblat Thomas Kirchner Olivier Delattre Thomas G. P. Grünewald
author_sort	Julian Musa
title	Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
title_short	Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
title_full	Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
title_fullStr	Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
title_full_unstemmed	Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
title_sort	cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b15283577e6941feafb9a8d8c4019ddd
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Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes

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